최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.26 no.2, 2011년, pp.31 - 37
이영준 (대구한의대학교 한의과대학 예방의학교실) , 강수진 (영남대학교 약학대학) , 구세광 (대구한의대학교 한의과대학 해부조직학교실)
Objectives : This study was focused to investigate the toxicity of Saussurea lappa (SL) extracts in HL-60 cells and human lymphocytes. We also examined the differentiation effect of SL against leukemia cells. Methods : For examining the toxicity of SL, cytokinesis-block micronucleus (CBMN) assay and...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
木香이란 무엇인가? | 木香은 Saussurea lappa Clarke의 뿌리를 건조한 것으로 한의학에서 通氣止痛, 止瀉止痢하는 작용이 있어 腹痛과 後重을 치료하는 약재로 사용되고 있다1). 木香의 주요 유효성분은 sesquiterpenes, polyene alcohols, triterpenes, lignans, alkaloids와 tannins으로서, costunolide는 sesquiterpene lactone의 일종으로 세포독성을 유발시키는 반면에 항암효과와 항염증효과, chemopreventive effect 등을 포함하는 다양한 작용을 하는 것으로 보고되고 있다2-5). | |
木香은 한의학에서 어떻게 사용되고 있는가? | 木香은 Saussurea lappa Clarke의 뿌리를 건조한 것으로 한의학에서 通氣止痛, 止瀉止痢하는 작용이 있어 腹痛과 後重을 치료하는 약재로 사용되고 있다1). 木香의 주요 유효성분은 sesquiterpenes, polyene alcohols, triterpenes, lignans, alkaloids와 tannins으로서, costunolide는 sesquiterpene lactone의 일종으로 세포독성을 유발시키는 반면에 항암효과와 항염증효과, chemopreventive effect 등을 포함하는 다양한 작용을 하는 것으로 보고되고 있다2-5). | |
목향의 성분 중에서 costunolide는 어떤 물질로 알려져 있는가? | 기존의 연구에서 sesquiterpenes, polyene alcohols, triterpenes, lignans, alkaloids와 tannins 등이 목향의 성분으로 분석되었으며, 그 중 costunolide와 dehydrocostus lactone과 같은 sesquiterpene lactones이 주요 유효성분을 이루어 생약학적 작용을 나타내고 있다2,5,18,19). 목향의 유효성분 중 costunolide는 약리학적으로 동맥수축억제작용20), 항염21)과 항궤양효과22)를 나타내는 물질로 알려지고 있으나, 다양한 사람 암세포에서 세포독성을 가지고 있는 연구결과들이 발표되었다23-25). 또한, 기존의 연구에서 목향의 메탄올 분획법에 따라 추출된 추출물들이 암세포주인 A549, SK-OV-3, SK-MEL-2, XF498과 HCT15 cell line들에게서 세포독성을 가지고 있음이 확인되었다26). |
Chen CR, A grand dictionary of oriental medicinal herbs. Seoul:Songak. 1990:212-5.
Robles M, Aregullin M, West J, Rodriguez E. Recent studies on the zoophamacognosy, pharmacology and neurotaxicology of sesquiterpene lactones. Planta Med. 1995;61:199-203.
Yamahara J, Kobayashi M, Miki K, Kozuka M, Fujimura H. Cholagogic and antiulcer effect of saussureae radix and its active comphnents. Chem Pham Bull. 1985;33:1285-8.
Mori H, Kawamori T, Tanaka T, Ohnishi M, Yamahara J. Chemopreventive effect of costunolide, a constituent of oriental medicine, on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett. 1994;83:171-5.
Ohnishi M, Yoshimi N, Kawamori T, Ino N, Hirose Y, Tanaka T, Yamahara J, Miyata H, Mori H. Inhibitory effects of dietary protocatechuic acid and costunolide on 7,12-dimethylbenz[a]anthracene-induced hamster cheek pouch carcinogenesis. Jpn J Cancer Res. 1997;88:111-9.
Taniguche M, Kataoka T, Suzuke H, Uramoto M, Ando M, Arao K, Magae J, Nishimura T, Otake N, Nagai K. Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes. Biosci Biotechnol Biochem. 1995;59:2064-7.
Beere HM, Hickman JA, Differenetiation : a suitable strategy for cancer chemotherapy? Anticancer Drug Des. 1993;8:299-322.
Choi JH, Seo BR, Seo SH, Lee KT, Park JH, Park HJ, Choi JW, Itoh Y, Miyamoto K. Costunolide induces differentiation of human leukemia HL-60 cells. Arch Pharm Res. 2002;25:480-4.
Kim SH, Kang SN, Kim HJ, Kim TS. Potentiation of 1,25-dihydroxyvitamin D3-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone. Biochem Pharmacol. 2002;64:1233-42.
Kim SH, Danilenko M, Kim TS. Differential enhancement of leukemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds. Br J Pharmacol. 2008;155:814-25.
Singh NP, Stephens RE, Schneider EL. Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int J Radiat Biol. 1994;66(1):23-8.
M Bemba-Meka P, Lemieux N, Chakrabarti SK. Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel sulfate-induced human lymphocyte death in vitro, Chem Biol Interact. 2005;156:69-80.
Fenech M, Morley A. Measurement of micronuclei in lymphocytes. Mutat Res. 1985;147:29-36.
Fenech M. The in vitro micronucleus technique. Mutat Res. 2000;455:81-95.
Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC. Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide. J Exp Med 1979;149:969-74.
Kim SH, Lee KH, An DK, Lee SI, Lee YJ, Kang BS, Ko WC, Rho SH, Song HJ, Shin MK, Ju YS. Herbology. Seoul:Younglimsa. 1992;353-4.
Bensky D, Gamble A. Chinese herbal medicine : Materia medica. Eastland press. Seattle. 1986;339-40.
Matsuda H, Toguchida I, Ninomiya K, Kageura T, Morikawa T, Yoshikawa M. Effects of sesquiterpenes and amino acid-sesquterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages. Bioorg Med Chem. 2003;11:709-15.
Hisashi M, Tadashi K, Yasunao I, Toshio M, Masayuki Y. Absolute stereostructures and syntheses of saussureanines A, B, C, D and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots of Saussurea lappa. Tetrahedron. 2000;56:7763-77.
Shoji N, Umeyama A, Saits N, Takemoto T. Vasoactive substances from Saussurea lappa. J Nat Prod. 1986;49:1112-3.
Kang JS, Yoon YD, Lee KH, Park SK, Kim HM. Costunolide inhibits interleukin- $1{\beta}$ expression by down-regulation of AP-1 and MAPK activity on LPS-stimulated RAW 264.7 cells. Biochem Biophys Res Commun. 2004;313:171-7.
Yamahara J, Kobayashi M, Miki K, Kozuka M, Sawada T, Fujimura H. Cholagogic and antiulcer effect of Saussurea radix and its components. Chem Pharm Bull. 1985;33:1285-8.
Park SH, Choi SU, Lee CO, Yoo SE, Yoon SK, Kim YK, Ryu SY. Costunolide, a sesquiterpene from the stem bark of Magnolia sieboldii, inhibits the RAS-farnesyl-proteintransferase. Planta Med. 2001;67:358-9.
Lee MG, Lee KT, Chi SG, Park JH. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability and cytochrome C release. Biol Pharm Bull. 2001;24:303-6.
Jeong SJ, Itokawa T, Shibuya M, Kuwano M, Ono M, Higuchi R, Miyamoto T. Costunolide, a sesquiterpene lactone from Saussurea lappa inhibits the VEGER KDR/FLK-1 signaling pathway. Cancer Lett. 2002;187:129-33.
Jung JH, Kim YS, Lee CO, Kang SS, Im KS. Cytotoxic sonstituents of Saussurea lappa. Arch Phar Res. 1998;21:153-6.
Ostling O, Johanson KJ. Microelectrophoretic study of radiation-induced DNA damage in individual mammalian cells. Biochem Biophys Res Commun. 1984;123:291-8.
Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res. 1988;175:184-91.
Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF. Single cell gel/Comet assay : Guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mut. 2000;35:206-21.
Ko SG, Kim HP, Jin DH, Bae HS, Kim SH, Park CH, Lee JW. Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells. Cancer Lett. 2005;220:11-9.
Albertini RJ, Anderson D, Douglas GR, Hagmar L, Hemminki K, Merlo F, Natarajan AT, Norppa H, Shuker DEG, Tice R, Waters MD, Aitio A. IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. Mut Res. 2000;463:111-72.
Kim HJ, Hong WS. A dictionary of oriental medicine. Seoul:Seongbosa. 1991:342-56.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
Free Access. 출판사/학술단체 등이 허락한 무료 공개 사이트를 통해 자유로운 이용이 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.