최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기생물정신의학 = Korean journal of biological psychiatry, v.18 no.3, 2011년, pp.109 - 118
최미란 (한양대학교 분자생명과학부) , 채영규 (한양대학교 분자생명과학부) , 이분희 (한국음주문화연구재단, 카프병원) , 이준석 (한국음주문화연구재단, 카프병원)
Objectives Many studies have suggested different neurobiological findings and clinical courses in alcoholism. Recently, subtyping in alcohol dependence has become essential to overcome the heterogeneity of patients. Among several criteria of subtypes, Lesch's typology is proposed to integrate biolog...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
알코올의존의 특징은? | 알코올의존(alcohol dependence)은 예방이 가능한 만성적 질환으로서 오늘날 주요한 공공 보건문제들 가운데 하나다. 사회 및 직업적 손실을 유발하는 알코올의존의 기전을 밝히려는 연구가 지속되었지만, 아직 일관된 결론을 찾지 못하고 있다. | |
알코올의존의 이질성은 무엇 때문에 발생하는가? | 알코올의존의 이질성은 일차적으로 생물학적, 사회적 및 심리적 요인들이 복합적으로 작용하여 이 질환을 유발시키기 때문에 발생한다.1) 예를 들어 과음(heavy drinking)의 시작 연령, 음주 양상(예를 들어, 지속적 음주 혹은 폭음), 알코올대사, 해독 능력, 공존정신질환 등의 요인들이 다르게 작용한다. | |
알코올의존의 원인 및 경과를 이해하는 과정이 복잡한 이유는? | 사회 및 직업적 손실을 유발하는 알코올의존의 기전을 밝히려는 연구가 지속되었지만, 아직 일관된 결론을 찾지 못하고 있다. 이는 알코올의존의 발병 형태가 이질성(heterogeneity)을 갖기 때문이다. 이 때문에 알코올의존의 원인 및 경과를 이해하는 과정은 매우 복잡하다. |
Cloninger CR, Bohman M, Sigvardsson S. Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Arch Gen Psychiatry 1981;38:861-868.
Addolorato G, Abenavoli L, Leggio L, Gasbarrini G. How many cravings? Pharmacological aspects of craving treatment in alcohol addiction: a review. Neuropsychobiology 2005;51:59-66.
Potgieter AS, Deckers F, Geerlings P. Craving and relapse measurement in alcoholism. Alcohol Alcohol 1999;34:254-260.
Tabakoff B, Hoffmann PL. Biological Aspects of Alcoholism. Toronto: Hogrefe & Huber Publishers;1995.
Silkworth WD. Alcoholism as a manifestation of allergy. Medical Record 1937;145:249-251.
Lemere F, Voegtlin WL, Broz WR, O'Hollaren P, Tupper WE. Heredity as an etiologic factor in chronic alcoholism. Northwestern Medicine 1943;42:110-111.
Jellinek EM. The disease concept of alcoholism. New Brunswick: Hill-house Press;1960.
Babor TF, Hofmann M, DelBoca FK, Hesselbrock V, Meyer RE, Dolinsky ZS, et al. Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry 1992;49:599-608.
Yoshino A, Kato M, Takeuchi M, Ono Y, Kitamura T. Examination of the tridimensional personality hypothesis of alcoholism using empirically multivariate typology. Alcohol Clin Exp Res 1994;18:1121-1124.
Sannibale C, Hall W. An evaluation of Cloninger's typology of alcohol abuse. Addiction 1998;93:1241-1249.
Epstein EE, Labouvie E, McCrady BS, Jensen NK, Hayaki J. A multisite study of alcohol subtypes: classification and overlap of unidimensional and multi-dimensional typologies. Addiction 2002;97:1041-1053.
Hill SY. Absence of paternal sociopathy in the etiology of severe alcoholism: is there a type III alcoholism? J Stud Alcohol 1992;53:161-169.
Hauser J, Rybakowski J. Three clusters of male alcoholics. Drug Alcohol Depend 1997;48:243-250.
Lee DK, Shin JK, Chung YI. A Study on the Types of Alcohol Dependence by Alcohol Use Inventory and Their Characteristics. J Korean Neuropsychiatr Assoc 2000;39:1132-1142.
Del Boca FK, Hesselbrock MN. Gender and alcoholic subtypes. Alcohol Health Res World 1996;20:56-62.
Driessen M, Lange W, Junghanns K, Wetterling T. Proposal of a comprehensive clinical typology of alcohol withdrawal--a cluster analysis approach. Alcohol Alcohol 2005;40:308-313.
Lesch OM, Kefer J, Lentner S, Mader R, Marx B, Musalek M, et al. Diagnosis of chronic alcoholism--classificatory problems. Psychopathology 1990;23:88-96.
De Witte P. Imbalance between neuroexcitatory and neuroinhibitory amino acids causes craving for ethanol. Addict Behav 2004;29:1325-1339.
Walter H, Ramskogler-Skala K, Dvorak A, Gutierrez-Lobos K, Hartl D, Hertling I, et al. Glutamic acid in withdrawal and weaning in patients classified according to Cloninger's and Lesch's typologies. Alcohol Alcohol 2006;41:505-511.
Breese GR, Overstreet DH, Knapp DJ. Conceptual framework for the etiology of alcoholism: a "kindling"/stress hypothesis. Psychopharmacology (Berl) 2005;178:367-380.
Hillemacher T, Bayerlein K, Wilhelm J, Bonsch D, Poleo D, Sperling W, et al. Recurrent detoxifications are associated with craving in patients classified as type 1 according to Lesch's typology. Alcohol Alcohol 2006;41:66-69.
Bleich S, Bleich K, Kropp S, Bittermann HJ, Degner D, Sperling W, et al. Moderate alcohol consumption in social drinkers raises plasma homocysteine levels: a contradiction to the 'French Paradox'? Alcohol Alcohol 2001;36:189-192.
Cravo ML, GlOria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, et al. Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status. Am J Clin Nutr 1996;63:220-224.
Saffroy R, Benyamina A, Pham P, Marill C, Karila L, Reffas M, et al. Protective effect against alcohol dependence of the thermolabile variant of MTHFR. Drug Alcohol Depend 2008;96:30-36.
Bleich S, Degner D, Sperling W, BOnsch D, Thurauf N, Kornhuber J. Homocysteine as a neurotoxin in chronic alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:453-464.
Bleich S, Degner D, Bandelow B, von Ahsen N, Ruther E, Kornhuber J. Plasma homocysteine is a predictor of alcohol withdrawal seizures. Neuroreport 2000;11:2749-2752.
Bleich S, Bayerlein K, Reulbach U, Hillemacher T, Bonsch D, Mugele B, et al. Homocysteine levels in patients classified according to Lesch's typology. Alcohol Alcohol 2004;39:493-498.
Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.
Wurst FM, Rasmussen DD, Hillemacher T, Kraus T, Ramskogler K, Lesch O, et al. Alcoholism, craving, and hormones: the role of leptin, ghrelin, prolactin, and the pro-opiomelanocortin system in modulating ethanol intake. Alcohol Clin Exp Res 2007;31:1963-1967.
Kiefer F, Jahn H, Jaschinski M, Holzbach R, Wolf K, Naber D, et al. Leptin: a modulator of alcohol craving? Biol Psychiatry 2001;49:782-787.
Hillemacher T, Bleich S, Frieling H, Schanze A, Wilhelm J, Sperling W, et al. Evidence of an association of leptin serum levels and craving in alcohol dependence. Psychoneuroendocrinology 2007;32:87-90.
Kim DJ, Yoon SJ, Choi B, Kim TS, Woo YS, Kim W, et al. Increased fasting plasma ghrelin levels during alcohol abstinence. Alcohol Alcohol 2005;40:76-79.
Addolorato G, Capristo E, Leggio L, Ferrulli A, Abenavoli L, Malandrino N, et al. Relationship between ghrelin levels, alcohol craving, and nutritional status in current alcoholic patients. Alcohol Clin Exp Res 2006;30:1933-1937.
Hillemacher T, Kraus T, Rauh J, Weiss J, Schanze A, Frieling H, et al. Role of appetite-regulating peptides in alcohol craving: an analysis in respect to subtypes and different consumption patterns in alcoholism. Alcohol Clin Exp Res 2007;31:950-954.
Chick J, Howlett H, Morgan MY, Ritson B. United Kingdom Multicentre Acamprosate Study (UKMAS): a 6-month prospective study of acamprosate versus placebo in preventing relapse after withdrawal from alcohol. Alcohol Alcohol 2000;35:176-187.
Lesch OM, Riegler A, Gutierrez K, Hertling I, Ramskogler K, Semler B, et al. The European acamprosate trials: conclusions for research and therapy. J Biomed Sci 2001;8:89-95.
Wiesbeck GA, Weijers HG, Lesch OM, Glaser T, Toennes PJ, Boening J. Flupenthixol decanoate and relapse prevention in alcoholics: results from a placebo-controlled study. Alcohol Alcohol 2001;36:329-334.
Wiesbeck GA, Weijers HG, Lesch OM, Glaser T, Toennes PJ, Boening J. Flupenthixol decanoate and relapse prevention in alcoholics: results from a placebo-controlled study. Alcohol Alcohol 2001;36:329-334.
Biermann T, Reulbach U, Lenz B, Muschler M, Sperling W, Hillemacher T, et al. Herp mRNA expression in patients classified according to Lesch's typology. Alcohol 2009;43:91-95.
Hillemacher T, Bayerlein K, Wilhelm J, Frieling H, Sperling W, Kornhuber J, et al. Prolactin serum levels and alcohol craving-an analysis using Lesch's typology. Neuropsychobiology 2006;53:133-136.
Apostolopoulos M, Judd FK, Burrows GD, Norman TR. Prolactin response to dl-fenfluramine in panic disorder. Psychoneuroendocrinology 1993;18:337-342.
Trabert W, Caspari D, Bernhard P, Biro G. Inappropriate vasopressin secretion in severe alcohol withdrawal. Acta Psychiatr Scand 1992;85:376-379.
Taivainen H, Laitinen K, Tahtela R, Kilanmaa K, Valimaki MJ. Role of plasma vasopressin in changes of water balance accompanying acute alcohol intoxication. Alcohol Clin Exp Res 1995;19:759-762.
Doring WK, Herzenstiel MN, Krampe H, Jahn H, Pralle L, Sieg S, et al. Persistent alterations of vasopressin and N-terminal proatrial natriuretic peptide plasma levels in long-term abstinent alcoholics. Alcohol Clin Exp Res 2003;27:849-861.
Jahn H, Doring WK, Krampe H, Sieg S, Werner C, Poser W, et al. Preserved vasopressin response to osmostimulation despite decreased basal vasopressin levels in long-term abstinent alcoholics. Alcohol Clin Exp Res 2004;28:1925-1930.
Hillemacher T, Bayerlein K, Wilhelm J, Poleo D, Frieling H, Ziegenbein M, et al. Volume intake and craving in alcohol withdrawal. Alcohol Alcohol 2006;41:61-65.
Benyamina A, Saffroy R, Blecha L, Pham P, Karila L, Debuire B, et al. Association between MTHFR 677C-T polymorphism and alcohol dependence according to Lesch and Babor typology. Addict Biol 2009;14:503-505.
Bonsch D, Bayerlein K, Reulbach U, Fiszer R, Hillemacher T, Sperling W, et al. Different allele-distribution of mthfr 677 C -> T and mthfr -393 C -> a in patients classified according to subtypes of Lesch's typology. Alcohol Alcohol 2006;41:364-367.
Sperling W, Frank H, Martus P, Mader R, Barocka A, Walter H, et al. The concept of abnormal hemispheric organization in addiction research. Alcohol Alcohol 2000;35:394-399.
Sperling W, Biermann T, Bleich S, Galvin R, Maihofner C, Kornhuber J, et al. Non-right-handedness and free serum testosterone levels in detoxified patients with alcohol dependence. Alcohol Alcohol 2010;45:237-240.
Babor TF, Caetano R. Subtypes of substance dependence and abuse: implications for diagnostic classification and empirical research. Addiction 2006;101 Suppl 1:104-110.
Hesselbrock VM, Hesselbrock MN. Are there empirically supported and clinically useful subtypes of alcohol dependence? Addiction 2006;101 Suppl 1:97-103.
Samochowiec J, Kucharska-Mazur J, Grzywacz A, Pelka-Wysiecka J, Mak M, Samochowiec A, et al. Genetics of Lesch's typology of alcoholism. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:423-427.
Walter H, Ramskogler K, Semler B, Lesch OM, Platz W. Dopamine and alcohol relapse: D1 and D2 antagonists increase relapse rates in animal studies and in clinical trials. J Biomed Sci 2001;8:83-88.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.