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오덕환(五德丸)과 사신환(四神丸)의 항산화 및 항염증 효과
Anti-oxidative and anti-inflammatory effects of Odukhwan and Sasinhwan in RAW264.7 cells 원문보기

大韓韓醫學方劑學會誌 = Herbal formula science, v.20 no.2, 2012년, pp.65 - 82  

김태훈 (동국대학교 한의과대학 방제학교실) ,  조현진 (동국대학교 한의과대학 방제학교실) ,  박선동 (동국대학교 한의과대학 방제학교실)

Abstract AI-Helper 아이콘AI-Helper

Objectives : The aim of this study was verification of the anti-oxidative and anti-inflammatory effects of Odukhwan(ODH) and Sasinhwan(SSH) in mouse macrophage, RAW264.7 cells. Methods : To investigate the anti-oxidative effect and scavenging activities of DPPH radical, superoxide anions, nitric oxi...

주제어

질의응답

핵심어 질문 논문에서 추출한 답변
오덕환은 어떠한 처방인가? 오덕환(五德丸)은 『景岳全書』1)에 脾腎虛寒으로 飱泄鶩溏한 증상을 치료하는 처방으로 기록되어 있다. 이 처방은 乾薑, 補骨脂 各 4兩, 吳茱萸, 木香, 五味子 各 2兩으로 구성되어 있다.
오수유의 효과는 무엇인가? 오수유(Evodia officinalis DODE.)의 경우에도 신경보호효과14), 항암효과15), 항산화효과16) 등의 연구가 보고되어 있다.
오덕환은 무엇으로 구성되어 있나? 오덕환(五德丸)은 『景岳全書』1)에 脾腎虛寒으로 飱泄鶩溏한 증상을 치료하는 처방으로 기록되어 있다. 이 처방은 乾薑, 補骨脂 各 4兩, 吳茱萸, 木香, 五味子 各 2兩으로 구성되어 있다. 한국에서 臨床書로 가장 다용되는 서적 중의 하나인 『方藥合編』2)에도 본 처방이 기록되어 있는데, 『方藥合編』에서는 主治症을 ‘治脾腎虛寒 飱泄’ 이라고 하여 『景岳全書』와 동일하게 언급하고 있으며, 처방의 사용 용량도 동일하게 기재되어 있다.
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참고문헌 (41)

  1. 張介賓. 景岳全書?新方八陣. 서울:한미의학. 2006 :2608. 

  2. 黃度淵. 方藥合編. 서울:영림사. 2002:162-3. 

  3. Wei SM, Yan ZZ, Zhou J. Psoralea corylifolia protects against testicular torsion/detorsion-induced ischemia/reperfusion injury. J Ethnopharmacol. 2011;137(1):568-74. 

  4. Arora R, Dhaker AS, Adhikari M, Sharma J, Chawla R, Gupta D, Zheleva A, Karamalakova Y, Kumar R, Sharma RK, Sharma A, Sultana S, Sharma RK, Tripathi RP, Gadjeva V. Radical scavenging and radiomodulatory effects of Psoralea corylifolia Linn. substantiated by in vitro assays and EPR spectroscopy. Z Naturforsch C. 2011;66(1-2):35-46. 

  5. Szliszka E, Czuba ZP, S?dek Ł, Paradysz A, Krol W. Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia. Pharmacol Rep. 2011;63(1):139-48. 

  6. Liu S, Song XY, Wu CY, Han XH, Liu LL, Liu JW, Xu YC. Effects of serum containing Fructus Cnidii and Psoralea corylifolia on highly metastatic human breast cancer cell line MDAMB- 231BO and bone marrow stromal cell line ST-2. Zhong Xi Yi Jie He Xue Bao. 2010;8(9) :877-82. 

  7. Lee MH, Kim JY, Ryu JH. Prenylflavones from Psoralea corylifolia inhibit nitric oxide synthase expression through the inhibition of I-kappaB-alpha degradation in activated microglial cells. Biol Pharm Bull. 2005;28(12):2253-7. 

  8. Rajendra Prasad N, Anandi C, Balasubramanian S, Pugalendi KV. Antidermatophytic activity of extracts from Psoralea corylifolia(Fabaceae) correlated with the presence of a flavonoid compound. J Ethnopharmacol. 2004;91(1):21-4. 

  9. Khatune NA, Islam ME, Haque ME, Khondkar P, Rahman MM. Antibacterial compounds from the seeds of Psoralea corylifolia. Fitoterapia. 2004;75(2):228-30. 

  10. Wong RW, Rabie AB. Effect of Buguzhi(Psoralea corylifolia fruit) extract on bone formation. Phytother Res. 2010;24 Suppl 2:S155-60. 

  11. Tsai MH, Huang GS, Hung YC, Bin L, Liao LT, Lin LW. Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats. Am J Chin Med. 2007;35(4):669-80. 

  12. Xu Q, Pan Y, Yi LT, Li YC, Mo SF, Jiang FX, Qiao CF, Xu HX, Lu XB, Kong LD, Kung HF. Antidepressant-like effects of psoralen isolated from the seeds of Psoralea corylifolia in the mouse forced swimming test. Biol Pharm Bull. 2008;31(6):1109-14. 

  13. Chen Y, Wang HD, Xia X, Kung HF, Pan Y, Kong LD. Behavioral and biochemical studies of total furocoumarins from seeds of Psoralea corylifolia in the chronic mild stress model of depression in mice. Phytomedicine. 2007;14(7-8):523-9. 

  14. Kim ST, Kim JD, Lyu YS, Lee MY, Kang HW. Neuroprotective effect of some plant extracts in cultured CT105-induced PC12 cells. Biol Pharm Bull. 2006;29(10):2021-4. 

  15. Xu ML, Li G, Moon DC, Lee CS, Woo MH, Lee ES, Jahng Y, Chang HW, Lee SH, Son JK. Cytotoxicity and DNA topoisomerase inhibitory activity of constituents isolated from the fruits of Evodia officinalis. Arch Pharm Res. 2006;29(7):541-7. 

  16. Yamahara J, Yamada T, Kitani T, Naitoh Y, Fujimura H. Antianoxic action and active constituents of evodiae fructus. Chem Pharm Bull (Tokyo). 1989;37(7):1820-2. 

  17. Kim KJ, Yoon KY, Hong HD, Lee BY. Schisandra chinensis Prevents Hepatic Lipid Peroxidation and Oxidative Stress in Rats Subjected to Heat Environmental Stress. Phytother Res. 2012 Mar 3. doi: 10.1002/ptr.4640. 

  18. Zhang M, Liu M, Xiong M, Gong J, Tan X. Schisandra chinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy. J Ethnopharmacol. 2012;141(1):111-8. 

  19. Lin RD, Mao YW, Leu SJ, Huang CY, Lee MH. The immuno-regulatory effects of Schisandra chinensis and its constituents on human monocytic leukemia cells. Molecules. 2011;16(6) :4836-49. 

  20. Chen WW, He RR, Li YF, Li SB, Tsoi B, Kurihara H. Pharmacological studies on the anxiolytic effect of standardized Schisandra lignans extract on restraint-stressed mice. Phytomedicine. 2011;18(13):1144-7. 

  21. 마진열, 김진숙, 신순식, 정규용, 박갑주. Vibrio parahemolyticus에 대한 한방처방 [方藥合編] 및 그단미제의 항균활성에 관한 연구. 한국한의학연구원논문집. 1999;5(1):59-72. 

  22. 곽근신. The Stuy of the Protective Effect of Sasinhwan against TNBS-induced Colitis. 원광대학교 한의학전문대학원. 2003. 

  23. Brune B, Zhou J, Von Knethen A. Nitric oxide, oxidative stress, and apoptosis. Kidney Int Suppl. 2003;84:22-4. 

  24. Gyamfi MA, Yonamine M, Aniya Y. Free-radical scavenging action of medicinal herbs from Ghana. Gen Pharmacol. 1999;32:661-7. 

  25. Gotoh N, Niki E. Rates of interactions of superoxide with vitamin E, vitamin C and related compounds as measured by chemiluminescence. Biochim Biophys Acta. 1992;1115:201-7. 

  26. Sutherland H, Khundkar R, Zolle O, McArdle A, Simpson AW, Jarvis JC Salmons S. A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle. Nitric Oxide. 2001;5:475-81. 

  27. Kooy NW, Royall JA, Ischiropulos H, Beckman JS. Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radical Biol Med. 1994;16:149-56. 

  28. Desai A, Vyas T, Amiji M. Cytotoxicity and apopotosis enhancement in brain tumor cells upon coadministration of paclitaxel and ceramide in nanoemulsion formulations. J Pharm Sci. 2008;97(7):2745-56. 

  29. Wang H, Joseph JA. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med. 1999;27:612-6. 

  30. Rong Y, Geng Z, Lau BH. Ginko biloba attenuates oxidative stress in macrophages and endothelial cells. Free Radic Biol Med. 1996;20:121-7. 

  31. Wang S, Chen Y, He D, He L, Yang Y, Chen J, Wang X. Inhibition of vascular smooth muscle cell proliferation by serum from rats treated orally with Gastrodia and Uncaria decoction, a traditional Chinese formulation. J Ethnopharmacol. 2007;114(3):458-62. 

  32. Greig FH, Kennedy S, Spickett CM. Physiological effects of oxidized phospholipids and their cellular signaling mechanisms in inflammation. Free Radic Biol Med. 2012;52(2):266-80. 

  33. Wadley AJ, Veldhuijzen van Zanten JJ, Aldred S. The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad. Age(Dordr). 2012 Mar 28. [Epub ahead of print] 

  34. Piaru SP, Mahmud R, Abdul Majid AM, Mahmoud Nassar ZD. Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. Asian Pac J Trop Med. 2012;5(4):294-8. 

  35. Akinboro A, Mohamed KB, Asmawi MZ, Sulaiman SF, Sofiman OA. Antioxidants in aqueous extract of Myristica fragrans (Houtt.) suppress mitosis and cyclophosphamide-induced chromosomal aberrations in Allium cepa L. cells. J Zhejiang Univ Sci B. 2011;12(11) :915-22.36. Lee MY, Yuk JE, Kwon OK, Oh SR, Lee HK, Ahn KS. Zuonin B Inhibits Lipopolysaccharide -Induced Inflammation via Downregulation of the ERK1/2 and JNK Pathways in RAW264.7 Macrophages. Evid Based Complement Alternat Med. 2012;2012:728196. 

  36. Lee MY, Yuk JE, Kwon OK, Oh SR, Lee HK, Ahn KS. Zuonin B Inhibits Lipopolysaccharide -Induced Inflammation via Downregulation of the ERK1/2 and JNK Pathways in RAW264.7 Macrophages. Evid Based Complement Alternat Med. 2012;2012:728196. 

  37. Qui M, Paromov VM, Yang H, Smith M, Stone WL. Inhibition of inducible Nitric Oxide Synthase by a mustard gas analog in murine macrophages. BMC Cell Biol. 2006;7:39. 

  38. Dong Hyun Park, Young-Chae Kim, Chang-Kiu Moon, Yi-Sook Jung, Eun Joo Baik, Chang Hyun Moon and Soo Hwan Lee. Cadmiuminduced COX-2 Expression in Cerebrovascular Endothelial Cells. J Environ Toxicol. 2006; 21(3):275-82. 

  39. Joo SS, Park D, Shin S, Jeon JH, Kim TK, Choi YJ, Lee SH, Kim JS, Park SK, Hwang BY, Lee do I, Kim YB. Anti-allergic effects and mechanisms of action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene -induced inflammation models. Environ Toxicol Pharmacol. 2010;30(2):127-33. 

  40. Leung PO, Wang SH, Lu SH, Chou WH, Shiau CY, Chou TC. Simvastatin inhibits pro-inflammatory mediators through induction of heme oxygenase-1 expression in lipopolysaccharide -stimulated RAW264.7 macrophages. Toxicol Lett. 2011;207(2):159-66. 

  41. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS. Molecular mechanisms underlying chemopreventive activities of antiinflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res. 2001; 480-481:243-68. 

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