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NTIS 바로가기생물정신의학 = Korean journal of biological psychiatry, v.19 no.4, 2012년, pp.179 - 186
나경세 (순천향대학교 의과대학 부천병원 정신건강의학교실) , 김신겸 (순천향대학교 의과대학 부천병원 정신건강의학교실) , 이소영 (순천향대학교 의과대학 부천병원 정신건강의학교실) , 정한용 (순천향대학교 의과대학 부천병원 정신건강의학교실)
Depression and executive dysfunction are common neuropsychiatric sequelae of stroke. Patients with stroke are more predisposed to depression and executive dysfunction compared to patients with similar degree of physical disability. Both depression and executive dysfunction are also associated with p...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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뇌졸중 후 우울증의 치료로 가장 널리 연구된 것은 무엇인가? | 앞서 살펴보았듯이, 뇌졸중 후 우울증의 유병률은 매우 높으며, 각종 정신사회적 기능을 저해하고 예후를 악화시키므로 적극적인 치료적 개입이 필요하다. 뇌졸중 후 우울증의 치료로 가장 널리 연구된 것은 선택적 세로토닌 재흡수차단제(selective serotonin reuptake inhibitor, 이하 SSRI)를 중심으로 하는 항우울제이다. 이미 많은 연구들에서 뇌졸중 후 우울증의 치료에 있어서 항우울제가 위약에 비하여 유의하게 높은 효능이 있음을 보고해왔다. | |
뇌졸중이란 무엇인가? | 뇌졸중(腦卒中, stroke)은 부분적 혹은 전반적 뇌기능 이상의 임상적 징후들이 급격히 발생하여 24시간 이상 지속되거나 혹은 그로 인하여 죽음에 이르게 되는 질환으로, 혈관성 질환의외에 달리 그 원인을 찾을 수 없는 경우를 말한다.1) 2011년 통계청 자료에 따르면 뇌졸중은 인구 10만 명당 사망자 53. | |
백질과강도란 무엇인가? | 최근 활발히 연구되고 있는 백질과강도(white matter hyperintensities, 이하 WMHI)는 이러한 뇌졸중과 우울증, 그리고 실행기능부전이 FSC 손상이라는 공통된 기전을 지니고 있다는 것을 뒷받침해준다. WMHI는 T2 뇌자기공명영상(magnetic resonance imaging, 이하 MRI) 촬영에서 특히 고신호강도로 나타나는 영상의학적 소견이다. 뇌졸중 및 소혈관질환 등으로 인하여 뇌혈관이 손상을 받게 되면서 백질 부위의 관류저하 및 혈뇌장벽(blood-brain barrier)의 손상이 발생할 수 있고, 이로 인하여 혈장(plasma)이 과도하게 백질 부위로 유출되어 WMHI 소견이 나타날 수 있다. |
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