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Pharmacokinetics and Tissue Distribution of Psammaplin A, a Novel Anticancer Agent, in Mice

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.35 no.10, 2012년, pp.1849 - 1854  

Kim, Hak Jae (Department of Radiation Oncology, Seoul National University Hospital) ,  Kim, Tae Hwan (School of Pharmacy, Sungkyunkwan University) ,  Seo, Won Sik (College of Pharmacy, Catholic University of Daegu) ,  Yoo, Sun Dong (School of Pharmacy, Sungkyunkwan University) ,  Kim, Il Han (Department of Radiation Oncology, Seoul National University Hospital) ,  Joo, Sang Hoon (College of Pharmacy, Catholic University of Daegu) ,  Shin, Soyoung (College of Pharmacy, Wonkwang University) ,  Park, Eun-Seok (School of Pharmacy, Sungkyunkwan University) ,  Ma, Eun Sook (College of Pharmacy, Catholic University of Daegu) ,  Shin, Beom Soo (College of Pharmacy, Catholic University of Daegu)

Abstract AI-Helper 아이콘AI-Helper

This study reports the pharmacokinetics and tissue distribution of a novel histone deacetylase and DNA methyltransferase inhibitor, psammaplin A (PsA), in mice. PsA concentrations were determined by a validated LC-MS/MS assay method (LLOQ 2 ng/mL). Following intravenous injection at a dose of 10 mg/...

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참고문헌 (22)

  1. Gynecol. Oncol. M. Y. Ahn 108 27 2008 10.1016/j.ygyno.2007.08.098 Ahn, M. Y., Jung, J. H., Na, Y. J., and Kim, H. S., A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells. Gynecol. Oncol., 108, 27-33 (2008). 

  2. J. Org. Chem. L. Arabshahi 52 3584 1987 10.1021/jo00392a016 Arabshahi, L. and Schmitz, F. J., Brominated tyrosine metabolites from an unidentified sponge. J. Org. Chem., 52, 3584-3586 (1987). 

  3. Toxicol. Ind. Health R. P. Brown 13 407 1997 10.1177/074823379701300401 Brown, R. P., Delp, M. D., Lindstedt, S. L., Rhomberg, L. R., and Beliles, R. P., Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health, 13, 407-484 (1997). 

  4. Curr. Opin. Genet. Dev. J. R. Davie 8 173 1998 10.1016/S0959-437X(98)80138-X Davie, J. R., Covalent modifications of histones: expression from chromatin templates. Curr. Opin. Genet. Dev., 8, 173-178 (1998). 

  5. Nature G. Egger 429 457 2004 10.1038/nature02625 Egger, G., Liang, G., Aparicio, A., and Jones, P. A., Epigenetics in human disease and prospects for epigenetic therapy. Nature, 429, 457-463 (2004). 

  6. Lancet Oncol. M. Esteller 4 351 2003 10.1016/S1470-2045(03)01115-X Esteller, M., Relevance of DNA methylation in the management of cancer. Lancet Oncol., 4, 351-358 (2003). 

  7. Cancer Invest. M. Fouladi 24 521 2006 10.1080/07357900600814979 Fouladi, M., Histone deacetylase inhibitors in cancer therapy. Cancer Invest., 24, 521-527 (2006). 

  8. Oncogene M. A. Glozak 26 5420 2007 10.1038/sj.onc.1210610 Glozak, M. A. and Seto, E., Histone deacetylases and cancer. Oncogene, 26, 5420-5432 (2007). 

  9. Nature F. Grignani 391 815 1998 10.1038/35901 Grignani, F., De, Matteis, S., Nervi, C., Tomassoni, L., Gelmetti, V., Cioce, M., Fanelli, M., Ruthardt, M., Ferrara, F. F., Zamir, I., Seiser, C., Grignani, F., Lazar, M. A., Minucci, S., and Pelicci, P. G., Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature, 391, 815-818 (1998). 

  10. Nat. Rev. Genet. P. A. Jones 3 415 2002 10.1038/nrg962 Jones, P. A. and Baylin, S. B., The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428 (2002). 

  11. Anticancer Res. D. Kim 19 4085 1999 Kim, D., Lee, I. S., Jung, J. H., Lee, C. O., and Choi, S. U., Psammaplin A, a natural phenolic compound, has inhibitory effect on human topoisomerase II and is cytotoxic to cancer cells. Anticancer Res., 19, 4085-4090 (1999a). 

  12. Arch. Pharm. Res. D. Kim 22 25 1999 10.1007/BF02976431 Kim, D., Lee, I. S., Jung, J. H., and Yang, S. I., Psammaplin A, a natural bromotyrosine derivative from a sponge, possesses the antibacterial activity against methicillinresistant Staphylococcus aureus and the DNA gyraseinhibitory activity. Arch. Pharm. Res., 22, 25-29 (1999b). 

  13. Exp. Mol. Med. D. H. Kim 28 47 2007 10.1038/emm.2007.6 Kim, D. H., Shin, J., and Kwon, H. J., Psammaplin A is a natural prodrug that inhibits class I histone deacetylase. Exp. Mol. Med., 28, 47-55 (2007). 

  14. Radiat. Oncol. H. J. Kim 7 39 2012 10.1186/1748-717X-7-39 Kim, H. J., Kim, J. H., Chie, E. K., Young, P. D., Kim, I. A., and Kim, I. H., DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity. Radiat. Oncol., 7, 39-48 (2012). 

  15. Drug Metab. Dispos. C. L. Litterst 3 259 1975 Litterst, C. L., Mimnaugh, E. G., Reagan, R. L., and Gram, T. E., Comparison of in vitro drug metabolism by lung, liver, and kidney of several common laboratory species. Drug Metab. Dispos., 3, 259-265 (1975). 

  16. Nature X. Nan 393 386 1998 10.1038/30764 Nan, X., Ng, H. H, Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., and Bird, A., Transcriptional repression by methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature, 393, 386-389 (1998). 

  17. Bioorg. Med. Chem. Lett. G. M. Nicholas 12 2487 2002 10.1016/S0960-894X(02)00385-2 Nicholas, G. M., Eckman, L. L., Ray, S., Hughes, R. O., Pfefferkorn, J. A., Barluenga, S., Nicolaou, K. C., and Bewley, C. A., Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase. Bioorg. Med. Chem. Lett., 12, 2487-2490 (2002). 

  18. J. Nat. Prod. Y. Park 66 1495 2003 10.1021/np030162j Park, Y., Liu, Y., Hong, J., Lee, C.-O., Cho, H., Kim, D.-K., Im, K. S., and Jung, J. H., New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis. J. Nat. Prod., 66, 1495-1498 (2003). 

  19. J. Org. Chem. I. C. Piña 68 3866 2003 10.1021/jo034248t Piña, I. C., Gautschi, J. T., Wang, G. Y., Sanders, M. L., Schmitz, F. J., France, D., Cornell-Kennon, S., Sambucetti, L. C., Remiszewski, S. W., Perez, L. B., Bair, K. W., and Crews, P., Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase. J. Org. Chem., 68, 3866-3873 (2003). 

  20. Tetrahedron J. Shin 56 9071 2000 10.1016/S0040-4020(00)00761-4 Shin, J., Lee, H. S., Seo, Y., Rho, J. R., Cho, K. W., and Paul, V. J., New bromotyrosine metabolites from the sponge Aplysinella rhax. Tetrahedron, 56, 9071-9077 (2000). 

  21. Bioorg. Med. Chem. J. N. Tabudravu 10 1123 2002 10.1016/S0968-0896(01)00372-8 Tabudravu, J. N., Eijsink, V. G., Gooday, G. W., Jaspars, M., Komander, D., Legg, M., Synstad, B., and van, Aalten, D. M., Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax. Bioorg. Med. Chem., 10, 1123-1128 (2002). 

  22. Genes Dev. F. Watt 2 1136 1988 10.1101/gad.2.9.1136 Watt, F. and Molloy, P. L., Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. Genes Dev., 2, 1136-1143 (1988). 

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