최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Biomolecules & therapeutics, v.20 no.3, 2012년, pp.245 - 255
Yoon, Sang-Sun (Department of Pharmacy, College of Pharmacy, Dankook University) , AhnJo, Sang-Mee (Department of Pharmacy, College of Pharmacy, Dankook University)
Amyloid-
1 Aguado-Llera D Arilla-Ferreiro E Campos-Barros A Puebla-Jiménez L Barrios V Protective effects of insulin-like growth factor-I on the somatostatinergic system in the temporal cortex of beta-amyloid-treated rats. J. Neurochem. (2005) 92 607 615 15659230
2 Ahmed M Davis J Aucoin D Sato T Ahuja S Aimoto S Elliott J. I Van Nostrand W. E Smith S. O Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nat.Struct. Mol. Biol. (2010) 17 561 567 20383142
3 Akiyama H Kondo H Ikeda K Kato M McGeer P. L Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein(Abeta) deposition. Brain Res. (2001) 902 277 281 11384622
4 Ayoub S Melzig M. F Induction of neutral endopeptidase(NEP) activity of SK-N-SH cells by natural compounds from green tea. J. Pharm. Pharmacol. (2006) 58 495 501 16597367
5 Baig S Kehoe P. G Love S MMP-2, -3 and -9 levels and activity are not related to Abeta load in the frontal cortex in Alzheimer's disease. Neuropathol. Appl. Neurobiol. (2008) 34 205 215 17971072
6 Bateman R. J Munsell L. Y Morris J. C Swarm R Yarasheski K. E Holtzman D. M Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat. Med. (2006) 12 856 861 16799555
7 Bell R. D Sagare A.P Friedman A. E Bedi G. S Holtzman D.M Deane R Zlokovic B. V Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J. Cereb. Blood Flow Metab. (2007) 27 909 918 17077814
8 Belyaev N. D Nalivaeva N. N Makova N. Z Turner A. J Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep. (2009) 10 94 100 19057576
9 Bruno M. A Mufson E. J Wuu J Cuello A. C Increased matrix metalloproteinase 9 activity in mild cognitive impairment. J. Neuropathol. Exp. Neurol. (2009) 68 1309 1318 19915485
10 Bu G Cam J Zerbinatti C LRP in amyloid-beta production and metabolism. Ann. N. Y. Acad. Sci. (2006) 1086 35 53 17185504
11 Burgos-Ramos E Martos-Moreno G. A López M. G Herranz R Aguado-Llera D Egea J Frechilla D Cenarruzabeitia E León R Arilla-Ferreiro E Argente J Barrios V The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3 beta modulation. J. Neurochem. (2009a) 109 360 370 19220704
12 Burgos-Ramos E Puebla-Jiménez L Arilla-Ferreiro E Minocycline prevents Abeta(25-35)-induced reduction of soma-tostatin and neprilysin content in rat temporal cortex. Life Sci. (2009b) 84 205 210 19101571
13 Carare R. O Bernardes-Silva M Newman T. A Page A. M Nicoll J. A Perry V. H Weller R. O Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: signifi cance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol. Appl. Neurobiol. (2008) 34 131 144 18208483
14 Castellani R. J Smith M. A Compounding artefacts with uncertainty and an amyloid cascade hypothesis that is 'too big to fail'. J. Pathol. (2011) 224 147 152 21557219
15 Choi D. S Wang D Yu G. Q Zhu G Kharazia V. N Paredes J.P Chang W. S Deitchman J. K Mucke L Messing R. O PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc. Natl. Acad. Sci. USA (2006) 103 8215 8220 16698938
16 Danielyan L Schäfer R Schulz A Ladewig T Lourhmati A Buadze M Schmitt A. L Verleysdonk S Kabisch D Koeppen K Siegel G Proksch B Kluba T Eckert A Köhle C Schöneberg T Northoff H Schwab M Gleiter C. H Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin. Cell Death Differ. (2009) 16 1599 1614 19609278
17 Deane R Bell R. D Sagare A Zlokovic B. V Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol. Disord. Drug Targets (2009) 8 16 30 19275634
18 Deane R Wu Z Sagare A Davis J Du Yan S Hamm K Xu F Parisi M LaRue B Hu H. W Spijkers P Guo H Song X Lenting P. J Van Nostrand W. E Zlokovic B. V LRP/amyloid beta-peptide interaction mediates differential brain effl ux of Abeta isoforms. Neuron (2004) 43 333 344 15294142
19 Deb S Gottschall P. E Increased production of matrix metalloproteinases in enriched astrocyte and mixed hippocampal cultures treated with beta-amyloid peptides. J. Neurochem. (1996) 66 1641 1647 8627321
20 Deb S Zhang J. W Gottschall P. E Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide. J. Neurosci. Res. (1999) 55 44 53 9890433
21 Dong Y. F Kataoka K Tokutomi Y Nako H Nakamura T Toyama K Sueta D Koibuchi N Yamamoto E Ogawa H Kim-Mitsuyama S Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease. FASEB J. (2011) 25 2911 2920 21593435
22 Eckman E. A Adams S. K Troendle F. J Stodola B. A Kahn M.A Fauq A. H Xiao H. D Bernstein K. E Eckman C. B Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme. J. Biol. Chem. (2006) 281 30471 30478 16912050
23 Eckman E. A Watson M Marlow L Sambamurti K Eckman C. B Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. J. Biol. Chem. (2003) 278 2081 2084 12464614
24 Eisele Y. S Baumann M Klebl B Nordhammer C Jucker M Kilger E Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin. Mol. Biol. Cell. (2007) 18 3591 3600 17626163
25 El-Amouri S. S Zhu H Yu J Marr R Verma I. M Kindy M.S Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. Am. J. Pathol. (2008) 172 1342 1354 18403590
26 Espuny-Camacho I Dominguez D Merchiers P Van Rompaey L Selkoe D De Strooper B Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance. J. Alzheimers Dis. (2010) 20 1119 1132 20413872
27 Fabbro S Seeds N. W Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain. J. Neurochem. (2009) 109 303 315 19222708
28 Farris W Mansourian S Chang Y Lindsley L Eckman E. A Frosch M. P Eckman C. B Tanzi R. E Selkoe D. J Guenette S Insulin-degrading enzyme regulates the levels of insulin amyloid beta-protein and the beta-amyloid precursor protein, intracellular domain in vivo. Proc. Natl. Acad. Sci. USA (2003) 100 4162 4167 12634421
29 Farris W Schütz S. G Cirrito J. R Shankar G. M Sun X George A Leissring M. A Walsh D. M Qiu W. Q Holtzman D. M Selkoe D. J Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am. J. Pathol. (2007) 171 241 251 17591969
30 Floden A. M Combs C. K Microglia demonstrate age-dependent interaction with amyloid-β fibrils. J. Alzheimers Dis. (2011) 25 279 293 21403390
31 Frautschy S. A Yang F Irrizarry M Hyman B Saido T. C Hsiao K Cole G. M Microglial response to amyloid plaques in APPsw transgenic mice. Am. J. Pathol. (1998) 152 307 317 9422548
32 Hafez D Huang J. Y Huynh A. M Valtierra S Rockenstein E Bruno A. M Lu B DesGroseillers L Masliah E Marr R. A Neprilysin-2 is an important β-amyloid degrading enzyme. Am. J. Pathol. (2011) 178 306 312 21224067
33 Hama E Shirotani K Masumoto H Sekine-Aizawa Y Aizawa H Saido T. C Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons. J. Biochem. (2001) 130 721 726 11726269
34 Hardy J. A Higgins G. A Alzheimer's disease: the amyloid cascade hypothesis. Science (1992) 256 184 185 1566067
35 Hardy J Selkoe D. J The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 297 353 356 12130773
36 Hellström-Lindahl E Ravid R Nordberg A Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: inverse correlation with A beta levels. Neurobiol. Aging (2008) 29 210 221 17098332
37 Hildebrandt H Haldenwanger A Eling P False recognition correlates with amyloid-beta (1-42) but not with total tau in cerebrospinal fluid of patients with dementia and mild cognitive impairment. J. Alzheimers Dis. (2009) 16 157 165 19158431
38 Hong H Baik T Song K Nam I Chung M Jo S In silico study of interaction between neurotransmitters and β-amyloid peptide (Aβ): a novel working hypothesis of Aβ-mediated pathogenesis of Alzheimer’s disease. (Submitted)
39 Huang S. M Mouri A Kokubo H Nakajima R Suemoto T Higuchi M Staufenbiel M Noda Y Yamaguchi H Nabeshima T Saido T. C Iwata N Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J. Biol. Chem. (2006) 281 17941 17951 16636059
40 Iwata N Mizukami H Shirotani K Takaki Y Muramatsu S Lu B Gerard N. P Gerard C Ozawa K Saido T. C Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J. Neurosci. (2004) 24 991 998 14749444
41 Iwata N Tsubuki S Takaki Y Shirotani K Lu B Gerard N. P Gerard C Hama E Lee H. J Saido T. C Metabolic regulation of brain Abeta by neprilysin. Science (2001) 292 1550 1552 11375493
42 Jacobsen J. S Comery T. A Martone R. L Elokdah H Crandall D. L Oganesian A Aschmies S Kirksey Y Gonzales C Xu J Zhou H Atchison K Wagner E Zaleska M. M Das I Arias R. L Bard J Riddell D Gardell S. J Abou-Gharbia M Robichaud A Magolda R Vlasuk G. P Bjornsson T Reinhart P. H Pangalos M. N Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc. Natl. Acad. Sci. USA (2008) 105 8754 8759 18559859
43 Jaeger L. B Dohgu S Hwang M. C Farr S. A Murphy M. P Fleegal-DeMotta M. A Lynch J. L Robinson S. M Niehoff M.L Johnson S. N Kumar V. B Banks W. A Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. J. Alzheimers Dis. (2009) 17 553 570 19433890
44 Jarrett J. T Berger E. P Lansbury P. T. Jr The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry (1993) 32 4693 4697 8490014
45 Jo S. A Ahn K Kim E Kim H. S Jo I Kim D. K Han C Park M. H Association of BACE1 gene polymorphism with Alzheimer's disease in Asian populations: meta-analysis including Korean samples. Dement. Geriatr. Cogn. Disord. (2008) 25 165 169 18182766
46 Jung S. S Zhang W Van Nostrand W. E Pathogenic A beta induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells. J. Neurochem. (2003) 85 1208 1215 12753080
47 Kalinin S Richardson J. C Feinstein D. L A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. Curr. Alzheimer. Res. (2009) 6 431 437 19874267
48 Kim J. Y Kim D. H Kim J. H Lee D Jeon H. B Kwon S. J Kim S. M Yoo Y. J Lee E. H Choi S. J Seo S. W Lee J. I Na D. L Yang Y. S Oh W Chang J. W Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaques. Cell Death Differ. (2012) 19 680 691 22015609
49 Kim K. W Kim M. H Kim M. D Kim B. J Kim S. K Kim J. L Moon S. W Bae J. N Woo J. I Ryu S. H Yoon J.C Lee N. J Lee D. Y Lee D. W Lee S. B Lee J. J Lee JY Lee CU Chang S. M Jhoo J. H Cho M. J A nationwide survey on the prevalence of dementia and mild cognitive impairment in South Korea. J. Alzheimers Dis. (2011a) 23 281 291 21178286
50 Kim M. J Chae S. S Koh Y. H Lee S. K Jo S. A Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain. FASEB J. (2010) 24 4491 4502 20624932
51 Kim T Hinton D. J Choi D. S Protein kinase C-regulated aβ production and clearance. Int. J. Alzheimers Dis. (2011b) 857368 21274428
52 Kiss A Kowalski J Melzig M. F Effect of Epilobium angustifolium L. extracts and polyphenols on cell proliferation and neutral endopeptidase activity in selected cell lines. Pharmazie (2006) 61 66 69 16454210
53 Krauze M. T Saito R Noble C Bringas J Forsayeth J McKnight T. R Park J Bankiewicz K. S Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen. Exp. Neurol. (2005) 196 104 111 16109410
54 Laurén J Gimbel D. A Nygaard H. B Gilbert J. W Strittmatter S. M Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature (2009) 457 1128 1132 19242475
55 Leal M. C Dorfman V. B Gamba A. F Frangione B Wisniewski T Castaño E. M Sigurdsson E. M Morelli L Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology. J. Neuropathol. Exp. Neurol. (2006) 65 976 987 17021402
56 Leal M. C Surace E. I Holgado M. P Ferrari C. C Tarelli R Pitossi F Wisniewski T Castaño E. M Morelli L Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism. Biochim. Biophys. Acta (2012) 1823 227 235 22036964
57 Lee J. M Yin K. J Hsin I Chen S Fryer J. D Holtzman D. M Hsu C. Y Xu J Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy. Ann. Neurol. (2003) 54 379 382 12953271
58 Leissring M. A Farris W Chang A. Y Walsh D. M Wu X Sun X Frosch M. P Selkoe D. J Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formationsecondary pathology, and premature death. Neuron (2003) 40 1087 1093 14687544
59 Liang K Yang L Yin C Xiao Z Zhang J Liu Y Huang J Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin. J. Biol. Chem. (2010) 285 935 942 19897485
60 Liu Y Studzinski C Beckett T Murphy M. P Klein R. L Hersh L. B Circulating neprilysin clears brain amyloid. Mol. Cell Neurosci. (2010) 45 101 107 20558294
61 Love S Contribution of cerebral amyloid angiopathy to Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry (2004) 75 1 4 14707293
62 Madani R Poirier R Wolfer D. P Welzl H Groscurth P Lipp H. P Lu B El Mouedden M Mercken M Nitsch R. M Mohajeri M. H Lack of neprilysin suffices to generate murine amyloid-like deposits in the brain and behavioral defi cit in vivo. J. Neurosci. Res. (2006) 84 1871 1878 16998901
63 Marr R. A Rockenstein E Mukherjee A Kindy M. S Hersh L. B Gage F. H Verma I. M Masliah E Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J. Neurosci. (2003) 23 1992 1996 12657655
64 Meilandt W. J Cisse M Ho K Wu T Esposito L. A Scearce-Levie K Cheng I. H. Yu G. Q Mucke L Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J. Neurosci. (2009) 29 1977 1986 19228952
65 Melino G Draoui M Bernardini S Bellincampi L Reichert U Cohen P Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines. Cell Growth Differ. (1996) 7 787 796 8780892
66 Melzig M. F Escher F Induction of neutral endopeptidase and angiotensin-converting enzyme activity of SK-N-SH cells in vitro by quercetin and resveratrol. Pharmazie (2002) 57 556 558 12227197
67 Melzig M. F Janka M Enhancement of neutral endopeptidase activity in SK-N-SH cells by green tea extract. Phytomedicine (2003) 10 494 498 13678233
68 Miller B. C Eckman E. A Sambamurti K Dobbs N Chow K. M Eckman C. B Hersh L. B Thiele D. L Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc. Natl. Acad. Sci. USA (2003) 100 6221 6226 12732730
69 Miners J. S Ashby E Van Helmond Z Chalmers K. A Palmer L. E Love S Kehoe P. G Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy. Neuropathol. Appl. Neurobiol. (2008a) 34 181 193 17973905
70 Miners J. S Baig S Tayler H Kehoe P. G Love S Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity. J. Neuropathol. Exp. Neurol. (2009) 68 902 914 19606063
71 Miners J. S Kehoe P. G Love S Immunocapture-based fluorometric assay for the measurement of insulin-degrading enzyme activity in brain tissue homogenates. J. Neurosci. Methods (2008b) 169 177 181 18221786
72 Miners J. S Morris S Love S Kehoe P. G Accumulation of insoluble amyloid-β in down's syndrome is associated with increased BACE-1 and neprilysin activities. J. Alzheimers Dis. (2011) 23 101 108 20930275
73 Miners J. S van Helmond Z Chalmers K Wilcock G Love S Kehoe P. G Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy. J. Neuropathol. Exp. Neurol. (2006) 65 1012 1021 17021406
74 Miners J. S van Helmond Z Kehoe P. G Love S Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme. Brain Pathol. (2010a) 20 794 802 20175776
75 Miners J. S van Helmond Z Raiker M Love S Kehoe P. G ACE variants and association with brain Aβ levels in Alzheimer's disease. Am. J. Transl. Res. (2010b) 3 73 80 21139807
76 Miners J. S Verbeek M. M Rikkert M. O Kehoe P. G Love S Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid. J. Neurosci. Methods (2008c) 167 229 236 17904641
77 Mohajeri M. H Wollmer M. A Nitsch R. M Abeta 42-induced increase in neprilysin is associated with prevention of amyloid plaque formation in vivo. J. Biol. Chem. (2002) 277 35460 35465 12105192
78 Monro O. R Mackic J. B Yamada S Segal M. B Ghiso J Maurer C Calero M Frangione B Zlokovic B. V Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol. Aging (2002) 23 405 412 11959403
79 Mouri A Zou L. B Iwata N Saido T. C Wang D Wang M. W Noda Y Nabeshima T Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behav. Brain Res. (2006) 168 83 91 16360221
80 Mueller-Steiner S Zhou Y Arai H Roberson E. D Sun B Chen J Wang X Yu G Esposito L Mucke L Gan L Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron (2006) 51 703 714 16982417
81 Naert G Rivest S The role of microglial cell subsets in Alzheimer's disease. Curr. Alzheimer Res. (2011) 8 151 155 21418002
82 Nalivaeva N. N Beckett C Belyaev N. D Turner A. J Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J. Neurochem. (2012) 120 Suppl 1 167 185 22122230
83 Narita M Holtzman D. M Schwartz A. L Bu G Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. J. Neurochem. (1997) 69 1904 1911 9349534
84 Nielsen H. M Veerhuis R Holmqvist B Janciauskiene S Binding and uptake of A beta1-42 by primary human astrocytes in vitro. Glia (2009) 57 978 988 19062178
85 Numata K Kaplan D. L Mechanisms of enzymatic degradation of amyloid Beta microfibrils generating nanofilaments and nanospheres related to cytotoxicity. Biochemistry (2010) 49 3254 3260 20196618
86 Palmer J. C Baig S Kehoe P. G Love S Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta. Am. J. Pathol. (2009) 175 262 270 19541930
87 Palmer J. C Barker R Kehoe P. G Love S Endothelin-1 is Elevated in Alzheimer's Disease and Upregulated byAmyloid-β. J. Alzheimers Dis. (2012) 29 853 861 22330820
88 Pardossi-Piquard R Petit A Kawarai T Sunyach C Alves da Costa C Vincent B Ring S D'Adamio L Shen J Müller U St George Hyslop P Checler F Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron (2005) 46 541 554 15944124
89 Pflanzner T Petsch B André-Dohmen B Müller-Schiffmann A Tschickardt S Weggen S Stitz L Korth C Pietrzik C. U Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier. J. Cereb. Blood Flow Metab. (2012) 32 628 632 22293988
90 Pike C. J Walencewicz-Wasserman A. J Kosmoski J Cribbs D. H Glabe C. G Cotman C. W Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. J. Neurochem. (1995) 64 253 265 7798921
91 Poirier R Wolfer D. P Welzl H Tracy J Galsworthy M. J Nitsch R. M Mohajeri M. H Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit. Neurobiol. Dis. (2006) 24 475 483 17008108
92 Pulukuri S. M Estes N Patel J Rao J. S Demethylation-linked activation of urokinase plasminogen activator is involved in progression of prostate cancer. Cancer Res. (2007) 67 930 939 17283123
93 Rogers J Strohmeyer R Kovelowski C. J Li R Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia (2002) 40 260 269 12379913
94 Russo R Borghi R Markesbery W Tabaton M Piccini A Neprylisin decreases uniformly in Alzheimer's disease and in normal aging. FEBS Lett. (2005) 579 6027 6030 16226260
95 Rylski M Amborska R Zybura K Michaluk P Bielinska B Konopacki F. A Wilczynski G. M Kaczmarek L JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons. Mol. Cell Neurosci. (2009) 40 98 110 18976709
96 Rylski M Amborska R Zybura K Mioduszewska B Michaluk P Jaworski J Kaczmarek L Yin Yang 1 is a critical repressor of matrix metalloproteinase-9 expression in brain neurons. J. Biol. Chem. (2008) 283 35140 35153 18940814
97 Sagare A. P Deane R Zetterberg H Wallin A Blennow K Zlokovic B. V Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. J. Alzheimers Dis. (2011) 24 25 34 21157031
98 Sagare A Deane R Bell R. D Johnson B Hamm K Pendu R Marky A Lenting P. J Wu Z Zarcone T Goate A Mayo K Perlmutter D Coma M Zhong Z Zlokovic B. V Clearance of amyloid-beta by circulating lipoprotein receptors. Nat. Med. (2007) 13 1029 1031 17694066
99 Saito T Iwata N Tsubuki S Takaki Y Takano J Huang S. M Suemoto T Higuchi M Saido T. C Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nat. Med. (2005) 11 434 439 15778722
100 Savaskan E Hock C Olivieri G Bruttel S Rosenberg C Hulette C Müller-Spahn F Cortical alterations of angiotensin converting enzyme angiotensin II and AT1 receptor in Alzheimer's dementia. Neurobiol. Aging (2001) 22 541 546 11445253
101 Sehgal N Gupta A Valli R. K Joshi S. D Mills J. T Hamel E Khanna P Jain S. C Thakur S. S Ravindranath V Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc. Natl. Acad. Sci. USA (2012) 109 3510 3515 22308347
102 Selkoe D. J Alzheimer's disease. In the beginning... Nature (1991) 35 432 433 1684220
103 Shibata M Yamada S Kumar S. R Calero M Bading J Frangione B Holtzman D. M Miller C. A Strickland D. K Ghiso J Zlokovic B. V Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. (2000) 106 1489 1499 11120756
104 Simard A. R Soulet D Gowing G Julien J. P Rivest S Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron (2006) 49 489 502 16476660
105 Spencer B Marr R. A Rockenstein E Crews L Adame A Potkar R Patrick C Gage F. H Verma I. M Masliah E Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. (2008) 9 109 19014502
106 Tanzi R. E Bertram L Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell (2005) 120 545 555 15734686
107 Tucker H. M Kihiko M Caldwell J. N Wright S Kawarabayashi T Price D Walker D Scheff S McGillis J. P Rydel R. E Estus S The plasmin system is induced by and degrades amyloid-beta aggregates. J. Neurosci. (2000) 20 3937 3946 10818128
108 Tucker H. M Simpson J Kihiko-Ehmann M Younkin L. H McGillis J. P Younkin S. G Degen J. L Estus S Plasmin defi ciency does not alter endogenous murine amyloid beta levels in mice. Neurosci. Lett. (2004) 368 285 289 15364412
109 Viswanathan A Greenberg S. M Cerebral amyloid angiopathy in the elderly. Ann. Neurol. (2011) 70 871 880 22190361
110 Wang H. Y Lee D. H Davis C. B Shank R. P Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors. J. Neurochem. (2000) 75 1155 1161 10936198
111 Wang R Wang S Malter J. S Wang D. S Effects of 4-hydroxy-nonenal and Amyloid-beta on expression and activity of endothelin converting enzyme and insulin degrading enzyme in SH-SY5Y cells. J. Alzheimers Dis. (2009a) 17 489 501 19363254
112 Wang R Wang S Malter J. S Wang D. S Effects of HNE-modifi cation induced by Abeta on neprilysin expression and activity in SH-SY5Y cells. J. Neurochem. (2009b) 108 1072 1082 19196432
113 Weller R. O Massey A Kuo Y. M Roher A. E Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's disease. Ann. N. Y. Acad. Sci. (2000) 903 110 117 10818495
114 Weller R. O Subash M Preston S. D Mazanti I Carare R. O Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol. (2008) 18 253 266 18363936
115 Wyss-Coray T Infl ammation in Alzheimer disease: driving force bystander or benefi cial response? Nat. Med. (2006) 12 1005 1015 16960575
116 Wyss-Coray T Loike J. D Brionne T. C Lu E Anankov R Yan F Silverstein S. C Husemann J Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat. Med. (2003) 9 453 457 12612547
117 Xiao Z. M Sun L Liu Y. M Zhang J. J Huang J Estrogen regulation of the neprilysin gene through a hormone-responsive element. J. Mol. Neurosci. (2009) 39 22 26 19127446
118 Yan P Hu X Song H Yin K Bateman R. J Cirrito J. R Xiao Q Hsu F. F Turk J. W Xu J Hsu C. Y Holtzman D. M Lee J. M Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. J. Biol. Chem. (2006) 281 24566 24574 16787929
119 Yang L Xu S Liu C Su Z In vivo metabolism study of ginsenoside Re in rat using high-performance liquid chromatography coupled with tandem mass spectrometry. Anal. Bioanal. Chem. (2009) 395 1441 1451 19774367
120 Yuyama K Sun H Mitsutake S Igarashi Y Sphingolipid-modulated exosome secretion promotes the clearance of amyloid-β by microglia. J. Biol. Chem. (2012) [Epub ahead of print]
121 Zou L. B Mouri A Iwata N Saido T. C Wang D Wang M. W Mizoguchi H Noda Y Nabeshima T Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid Beta and impairment of learning and memory. J. Pharmacol. Exp. Ther. (2006) 317 334 340 16382024
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.