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NTIS 바로가기韓國藥用作物學會誌 = Korean journal of medicinal crop science, v.20 no.2, 2012년, pp.129 - 135
The feature of asthma are airway inflammation (AI), reversible airway obstruction, and an increased sensitivity to bronchoconstricting agents, elevated airway hyperresponsiveness (AHR), excess production of Th2 cytokines, and eosinophil accumulation in the lungs. This study was performed to investig...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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황금의 항암효과 메카니즘은? | , 2002). 황금의 항암효과 메카니즘은 암세포와 염증에서 황금 추출물이 COX-2 활성도를 억제함으로써 PGE2 생성이 억제되기 때문이라고 보고하고 있다(Zang et al., 2003). | |
경유차 매연에 포함된 미세먼지에 함유된 오염물질과 이 물질들이 유발하는 질환은? | 003~0.1㎛)는 black carbon, hydrocarbons (C14-C35)과 그 유도체, heterocyclics, polycyclic aromatic hydrocarbons과 그 유도체, acids, alcohols, esters anhydrides, ketones, nitriles, quinones, sulfonates, organic halogens과 nitrates, inorganic sulfates와 nitrates 및 중금속 등을 함유하고 있으며 (Akiyama, 2006), 기도염증, 암이나 기관지 천식 등 알레르기성 만성호흡기 질환의 원인이 된다고 보고되고 있다 (Inoue et al., 2008). | |
디젤배기가스입자를 항원과 함께 생쥐에 투여한 연구 결과 어떤 현상이 나타났는가? | , 2004). 그리고 DEP를 항원과 함께 생쥐에 투여했을 때 기관지천식의 증상인 세기관지가 광범위하게 좁아지는 현상이 나타내며, 발작성인 호흡곤란이 자연적으로 혹은 치료에 의해서 원 상태로 되돌아가는 가역성의 성질을 보이고, 작은 자극에 의해서도 예민하게 기도과민성이 항진되며, 점액성분이 과다 분비된다고 보고되고 있다 (Lim and Lee, 2002; Lim et al., 1998; Sagai et al. |
Akiyama K. (2006). Gas chromatographic analysis and aerosol mass spectrometer measurement of diesel exhaust particles composition. Talanta. 70:178-181.
Cho YS, Lee JT, Jung CH, Chun YS and Kim YS. (2008). Relation between particulate matter measured by optical particle counter and mortality in Seoul, Korea, during 2001. Journal of Environmental Health. 71:37-43.
Cockcroft DW. (2010) Direct challenge tests. airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest. 138: 18S-24S.
Finkelman FD, Yang M, Orekhova T, Clyne E, Nerbstein J, Whitekus M, Diaz-Sabchez D and Morris SC. (2004). Diesel exhaust particles suppress in vivo IFN-gamma production by inhibiting cytokine effects on NK and NKT cells. The Journal of Immunology. 172:3808-3813.
Finotto S, De Sanctis GT, Lehr HA, Herz U, Buerke M, Schipp M, Bartsch B, Atreya R, Schmitt E, Galle PR, Renz H and Neurath MF. (2001). Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression. The Journal of Experimental Medicine. 193:1247-1260.
Gowdy K, Krantz QT, Daniels M, Linak WP, Jaspers I and Gilmour MI. (2008). Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust. Toxicological and Applied Pharmacology. 229:310-319.
Inoue KI, Koike E, Yanagisawa R and Takano H. (2008). Effects of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in asthmatic mice. Immunopharmacology and Immunotoxicology. 28:1-6.
Kim EH, Shim BS, Kang SH, Jeong GJ, Lee JS, Yue YB and Chun MS. (2009). Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules. Journal of Ethnopharmacology. 126:320-331.
Kim SH, Kim BG and Lee YC. (2011). Antiasthmatic effects on hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma. Mediators of Inflammation. 2011, ID 485-402, 12 pages.
Kim SJ, Moon YJ and Lee SM. (2010). Protective effects of baicalein against ischemia/reperfusin injury in rat liver. Journal of Natural Products. 73:2003-2008.
Kuhl K and Hananial VA. (2012). Targeting IgE in asthma. Current Opinion of Pulmonary Medicine. 18:1-5
Kumagai T, Muller CI, Desmond JC, Imai Y, heber D and Koeffler HP. (2007). Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leukemia Research. 31:523-530.
Lee IK, Kang KA, Zang R, Kim BJ, Kang SS and Hyun JW. (2011). Mitochondria protection of baicalein against oxidative damage via induction of manganease superoxide dismutase. Enviromental Toxicology & Pharmacology. 31:233-241.
Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S and Sugawara I. (2008). Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice. Clinical Immunology. 128:366-373.
Lim HB and Kim SH. (2009). The effect of crude saponins of Korean red ginseng against airway inflammation and airway hyperresponsiveness induced by dieasel exhaust particles in mice. Korean Journal of Medicinal Crop Science. 17:90-96.
Lim HB, Ichinose T, Miyabara Y, Takano H, Kumagai Y, Shimojyo N and Sagai M. (1998). Involvement of superoxide and nitric oxide on airway inflammation and hyperresponsiveness induced by diesel exhaust particles in mice. Free Radical Biology and Medicine. 25:635-644.
Liu J, Ballaney M, Alalem U, Quan C, Jin X, Perera F, Chen LC and Miller RL. (2008). Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T healper genes and IgE production in vivo. Toxicological Science. 102: 76-81.
Peden D and Reed CE. (2010). Environmental and occupational allergies. Journal of Clinical Immunology. 125:S150-S160.
Ris C. (2007). US EPA health assessment for diesel engine exhaust : a review. Inhalation Toxicology. 19:229-39.
Sagai M, Furuyama A and Ichinose T. (1996). Biological effects of diesel exhaust particles(DEP). III. Pathogenesis of asthmalike symptoms in mice. Free Radical Biology and Medicine. 21:199-209.
Sagai M, Saito H, Ichinose T, Kodama M and Mori Y. (1993). Biological effects of diesel exhaust particles. I. In Vitro production od superoxide and in vivo toxicity in mouse. Free Radical Biology and Medicine. 14: 37-47.
Takizawa H. (2003). Role of inflammatory cells in the development of airway inflammation. Nippon Rinsho Journal. 61:2107-2112.
Thomas A, Platts-Mills E and Woodfolk JA. (2011). Allergens and their role in the allergic immune response. Immunological Reviews. 242:51-68
Ye F, Xui L, Yi J, Zhang W and Zhang DY. (2002). Anticancer activity of Scutellaria baicalensis and its potential mechanism. The Journal of Alternative and Complementary Medicine. 8:567-572.
Yoon SB, Lee YJ, Park SK, Kim HC, Bae HS, Ko SG, Choi HY, Oh MS and Park WS. (2009). Anti-inflammatory effects of Scutellaria baicalensis water extract of RAW 264.7 macrophages. Journal of Ethnopharmacology. 125:286-290.
Yune TY, Lee JY, Cui CM, Kim HC and Oh TH. (2009). Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. Journal of Neurochemistry. 110:1276-1287.
Zang DY, Wu J, Ye F, Xue L, Jiang S and Yi J. (2003). Inhibition of cancer cell proliperation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Research. 63:4037-4043.
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