[논문]The Estrous Cycle and Induction of Ovulation in Mares

Yoon, Min-Jung

doi:10.5187/jast.2012.54.3.165

The Estrous Cycle and Induction of Ovulation in Mares 원문보기

한국동물자원과학회지 = Journal of animal science and technology, v.54 no.3, 2012년, pp.165 - 174

Yoon, Min-Jung (Division of Animal Science and Biotechnology, Kyungpook National University)

Abstract ▼ AI-Helper

For horse breeders or managers, it is critical to understand the estrous cycle of mares. Breeding of mares cannot be successfully achieved throughout the whole year as mares breed seasonally. Mares are only able to breed when day length is more than 16 h, and this period is known as the breeding season. Their estrous cycle is approximately 21 days with 5-7 days of estrus and 14 to 15 days of a diestrus period. The estrous cycle of the mare is mainly controlled by gonadotropins, which control follicular development and ovulation. Mares exhibit unique ovulatory events which are not observed in other species. A LH surge occurs for several days, with levels of LH reaching their peak after ovulation. The LH level at the time of LH peak is lower than most other species. The unique anatomical structure of the ovaries of mares is known to limit the number of eggs ovulated. Several attempts have been made to develop chemical/hormonal agents which might be used to manipulate the timed ovulation of mares. Agents that have been tested include hCG, native GnRH, Deslorelin (Ovuplant, GnRH-agonist), Buserelin (GnRH analogue), equine pituitary extracts and equine chorionic gonadotropin (eCG or PMSG). However, the function, purity or stability of these agents is not reliable. Recombinant equine LH, an alternative agent for the timed ovulation, has been developed and tested for its biological activities, through the use of both in vitro and in vivo experiments. The reLH was suggested to be a reliable agent in inducing ovulation within 48 h after being administered through injection, when the size of dominant follicle is 35 mm in diameter.

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제안 방법

, 2007). To test the biological effect of reLH, varying levels of reLH were added to equine Leydig cell cultures and the concentrations of reLH-stimulated testosterone were compared with that of native eLH. Different levels of reFSH were also added in seminiferous tubule cultures, and estradiol production was compared to that of native eFSH.

성능/효과

, 1973). The result of this study indicated that the duration of estrus and ovulation time appears ineffective upon the second administration of hCG. However, the mean duration of estrus was significantly extended, and ovulation took longer after the third administration of hCG.
3% mares in the control group ovulated within the same timeframe. The results of this study suggested that buserelin is not as efficient an agent as hCG in inducing ovulation in mares.

후속연구

The result of this study indicated that reLH is an ovulatory agent that induces ovulation in mares with 35 mm follicle size within 48 h. However, more studies should be carried out in order to test if this agent causes the generation of antibodies, and if its effect is consistent after multiple injections for several breeding season.

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