[논문]모르핀 중독의 침 연구에 사용된 경혈(經穴)에 대한 소고(小考)

이봉효; 임성철; 김재수; 이윤규; 이현종; 정태영; 정현정; 감철우

[국내논문] 모르핀 중독의 침 연구에 사용된 경혈(經穴)에 대한 소고(小考)
A Short Reveiw on the Acupoints Used in the Studies about Morphine Addiction 원문보기

경락경혈학회지= Korean journal of acupuncture, v.29 no.2, 2012년, pp.179 - 187

초록
AI-Helper

목적 : 침 치료는 약물 중독을 위한 효과적인 치료법으로 인정받은 이래 이에 관한 많은 연구들이 이루어지고 있다. 본 논문에서는 모르핀 중독의 침 치료에 사용된 경혈 및 소속 경락에 대해 육경(六經)적인 관점에서 이를 해석하였다. 방법 : 미국 국립 의학도서관(PubMed)에서 "모르핀, 침"을 주제어로 하여 255개의 논문을 검색하였고, 한국학술정보(주)(KISS)에서 "모르핀"을 주제어로 하여 629개의 논문을 검색하였다. 영어로 기술된 논문만을 연구 대상으로 하였다. 모르핀에 대한 중독(남용, 의존, 민감화, 중독, 섭취, 금단 증상, 금단 증후군, 재발, 갈망)과 관련된 논문만을 연구 대상으로 하였다. 침 또는 전침을 사용한 논문만을 연구 대상으로 하였으며, 이침을 사용한 것은 제외하였다. 임상 연구와 실험 연구를 모두 연구 대상으로 하였다. 결과 : 모르핀의 침 연구에서 가장 많이 사용된 경혈은 족삼리-삼음교(足三里-三陰交)(전침, 10회)로 나타났고, 그 다음은 신문(神門)(5회)이었으며, 그밖에 합곡(合谷)(2회), 신유(腎兪)(1회), 내관(內關)(1회) 등의 경혈이 사용되었다. 족삼리(足三里)는 장부상통에 의해 심포경과 통하는 위경을 조절함으로써 스트레스 반응에 관계된 심포경을 조절할 수 있음에 따라 모르핀 중독 연구에 사용된 것으로 보인다. 음양이총혈의 하나인 삼음교(三陰交)는 정신 기능에 영향을 미치는 혈분을 다스리며 식욕을 조절하는 기능 또한 이러한 효능에 관련된 것으로 사료된다. 수소음심경의 원혈인 신문(神門)은 뇌와 관계된 소속 경맥의 기능 및 혈명으로부터 정신 기능을 조절할 수 있음을 알 수 있다. 양계(陽谿)는 양명경의 원혈로서 상통하는 궐음경을 조절함으로써 스트레스 반응을 조절할 수 있기 때문에 사용된 것으로 보이며, 신유(腎兪)는 소속 경맥이 뇌와 관련되어 있기 때문에 사용된 것으로 사료된다. 내관(內關)은 모르핀 중독에 수반되는 스트레스를 조절할 수 있기 때문에 사용된 것으로 보인다. 결론 : 모르핀 연구에 사용된 경혈은 다양한 기전을 통해 뇌 기능에 영향을 미치는 것으로 보이며, 스트레스 반응을 조절하는 것이 이에 관련된 것으로 사료된다.

Abstract ▼ AI-Helper

Objectives : Since acupuncture was accepted as an useful therapy for the drug addiction, a lot of studies about acupuncture have been carried out. This study was performed to review the articles about morphine addiction which used acupuncture as a treatment and to interpret the use of acupoints from the viewpoint of Six-meridian (Yuk Gyeong, three yin and three yang) theory. Methods : The authors searched 255 articles in PubMed with the key word of "morphine, acupuncture" and 629 articles in KISS (Koreanstudies Information Service System) with the key word of "morphine". The articles written in English only were included. The articles related with morphine (abuse, dependence, sensitization, addiction, intake, withdrawal sign, withdrawal syndrome, reinstatement, craving) only were included. The articles which used manual- or electro-acupuncture only were included and auricular acupuncture was excluded. Both of clinical and experimental study were reivewed. Results : The most frequently used acupoint was ST36-SP6 (electroacupuncture), and the second was HT7. LI4 was the third, and BL23 and PC6 were also used. Conclusions : The acupoints used in the morphine study seem to influence the brain through diverse mechanisms and it is thought that control of the reaction against stress appears to be related with these mechanisms.

Keyword

AI 본문요약
AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

성능/효과

4) Articles using body acupuncture (manual or electrical) only were treated and auricular acupunctures were excluded.

참고문헌 (40)

Johnson SW, North RA. Opioids excite dopamine neurons by hyperpolarization of local interneurons. J Neurosci. 1992 ; 12(2) : 483-8.

상세보기
Vanderschuren LJ, De Vries TJ, Wardeh G, Hogenboom FA, Schoffelmeer AN. A single exposure to morphine induces long-lasting behavioural and neurochemical sensitization in rats. Eur J Neurosci. 2001 ; 14(9) : 1533-8.

상세보기
Wise RA, Bozarth MA. Action of drugs of abuse on brain reward systems: an update with specific attention to opiates. Pharmacol Biochem Behav. 1982 ; 17(2) : 239-43.

상세보기
Everitt BJ, Dickinson A, Robbins TW. The neuropsychological basis of addictive behaviour. Brain Res Brain Res Rev. 2001 ; 36(2-3) : 129-38.

상세보기
Jiang YH, Jiang W, Jiang LM, Lin GX, Yang H, Tan Y, et al. Clinical efficacy of acupuncture on the morphine-related side effects in patients undergoing spinal-epidural anesthesia and analgesia. Chin J Integr Med. 2010 ; 16(1) : 71-4.

상세보기
Bullock ML, Umen AJ, Culliton PD, Olander RT. Acupuncture treatment of alcoholic recidivism: a pilot study. Alcohol Clin Exp Res. 1987 ; 11(3) : 292-5.

상세보기
Anonymous. NIH Consensus Conference. Acupuncture. JAMA. 1998 ; 280(17) : 1518-24

상세보기
Lee BH, Park SY, Lee JH, Lim SC, Kim JS, Lee YK, et al. Duration pattern of the effect of acupuncture at HT7 in morphine self- administration. J Korean Acupuncture and Moxibustion Society. 2010 ; 27(4) : 55-65.
Yoon SS, Kim H, Choi KH, Lee BH, Lee YK, Lim SC, et al. Acupuncture suppresses morphine self-administration through the GABA receptors. Brain Res Bull. 2010 ; 81(6) : 625-30.

상세보기
Cheng RS, Pomeranz B, Yu G. Electroacupuncture treatment of morphine-dependent mice reduces signs of withdrawal, without showing cross-tolerance. Eur J Pharmacol. 1980 ; 68(4) : 477-81.

상세보기
Wang GB, Wu LZ, Yu P, Li YJ, Ping XJ, Cui CL. Multiple 100 Hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: Central preprodynorphin mRNA and p-CREB implicated. Peptides. 2011 ; 32(4) : 713-21.

상세보기
Liu S, Zhou W, Liu H, Yang G, Zhao W. Electroacupuncture attenuates morphine withdrawal signs and c-Fos expression in the central nucleus of the amygdala in freely moving rats. Brain Res. 2005 ; 1044(2) : 155-63.

상세보기
Lee JH, Kim HY, Jang EY, Choi SH, Han CH, Lee BH, et al. Effect of acupuncture on naloxone-precipitated withdrawal syndrome in morphine-experienced rats: the mediation of GABA receptors. Neurosci Lett. 2011 ; 504(3) : 301-5.

상세보기
Wu LZ, Cui CL, Tian JB, Ji D, Han JS. Suppression of morphine withdrawal by electroacupuncture in rats: dynorphin and kappaopioid receptor implicated. Brain Res. 1999 ; 851(1-2) : 290-6.

상세보기
Han JS, Zhang RL. Suppression of morphine abstinence syndrome by body electroacupuncture of different frequencies in rats. Drug Alcohol Depend. 1993 ; 31(2) : 169-75.

상세보기
Cui GH, Ren XW, Wu LZ, Han JS, Cui CL. Electroacupuncture facilitates recovery of male sexual behavior in morphine withdrawal rats. Neurochem Res. 2004 ; 29(2) : 397-401.

상세보기
Liang J, Ping XJ, Li YJ, Ma YY, Wu LZ, Han JS, et al. Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens. Neuropharmacology. 2010 ; 58(1) : 233-40.

상세보기
Wang B, Luo F, Xia YQ, Han JS. Peripheral electric stimulation inhibits morphine-induced place preference in rats. Neuroreport. 2000 ; 11(5) : 1017-20.

상세보기
Hu L, Chu NN, Sun LL, Zhang R, Han JS, Cui CL. Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area. Addict Biol. 2009 ; 14(4) : 431-7.

상세보기
Chen JH, Liang J, Wang GB, Han JS, Cui CL. Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats. Exp Neurol. 2005 ; 194(2) : 550-6.

상세보기
Lee B, Shim I, Lee H, Yin CS, Park HK, Yang JS, et al. Morphine-induced locomotor response and Fos expression in rats are inhibited by acupuncture. Neurol Res. 2010 ; 32 (Suppl 1) : 107-10.
Kim MR, Kim SJ, Lyu YS, Kim SH, Lee Y, Kim TH, et al. Effect of acupuncture on behavioral hyperactivity and dopamine release in the nucleus accumbens in rats sensitized to morphine. Neurosci Lett. 2005 ; 387(1) : 17-21.

상세보기
Chu NN, Xia W, Yu P, Hu L, Zhang R, Cui CL. Chronic morphine-induced neuronal morphological changes in the ventral tegmental area in rats are reversed by electroacupuncture treatment. Addict Biol. 2008 ; 13(1) : 47-51.

상세보기
Zhang Y, Du L, Wu G, Cao X. Electroacupuncture (EA) induced attenuation of immunosuppression appearing after epidural or intrathecal injection of morphine in patients and rats. Acupunct Electrother Res. 1996 ; 21(3-4) : 177-86.
The committee for publish of meridian and acupoint textbook. Meridian and Acupoint of College (Ant.) 5th ed. Wonju : Euibang Publishing Company. 2010 : 70, 256, 341, 345, 424,
Lee BH, Kim SJ, Jung CH, Kwon SY, Lim SC, Lee KM, et al. A study on the basic principle of the classification of sidong disease, sosaeng disease. J Korean Acupuncture and Moxibustion Society. 2008 ; 25(5) : 43-57.
Kwak DU, Park KW, Yang CH. Effects of acupuncture at the Chok - Sammi (ST36) locus on plasma renin activity and plasma aldosterone, electrolyte levels in men. J Korean Acupuncture and Moxibustion Society. 1991 ; 8(1) : 367-88.
Cho NG. Effect of acupuncture treatment at S 36 on the blood pressure and cerebral hemodynamics of rats. J Korean Acupuncture and Moxibustion Society. 1999 ; 16(4) : 307-19.
Kim YI, Kim YH, Im YG, Lee H, Lee BL, Kim YJ. A fMRI study on the cerebral activity induced by electro-acupuncture on Zusanli(St36). J Korean Acupuncture and Moxibustion Society. 2003 ; 20(5) : 133-50.
Ross J. Acupuncture point combinations: the key to clinical success. Philadelphia : Churchill Livingstone. 1995 : 177-8, 190, 213-7, 231-3, 277-9, 306-8, 320-1.
Hong KE, Lee BR, Lee H, Yim YK, Kim YJ. fMRI study on the cerebral activity induced by electro-acupuncture on Sanyinjiao (Sp6), J Korean Acupuncture and Moxibustion Society. 2003 ; 20(3) : 86-103.
Fortuna JL. Sweet preference, sugar addiction and the familial history of alcohol dependence: shared neural pathways and genes. J Psychoactive Drugs. 2010 ; 42(2) : 147-51.

상세보기
Jeong EW, Kim HS, Lee SK, Kim MS, Cho ZH, Sung KK. Effects of electroacupuncture on plasma stress hormone responses to acute and chronic immobilization stress. J Korean Acupuncture and Moxibustion Society. 2010 ; 27(5) : 105-15.
Lim SK, Lee DH, Kwon YJ, Lee JC, Jung CJ, Kim YS, et al. Effects of fixed-intensity and varied-intensity electroacupuncture on heart rate variability in healthy people with stress task. J Korean Acupuncture and Moxibustion Society. 2011 ; 28(2) : 107-16.
Jo MH, Choi BT, Jang KJ. The effects of 120 Hz high frequency electroacupuncture on the cold-restraint-induced gastric mucosal damages. J Korean Acupuncture and Moxibustion Society. 2003 ; 20(3) : 177-93.
Lee CH, Kim YH, Song BY, Yug TH. Expression of neurotransmitter (CRF, CRF-R and CRF-BP) related to stress in stomach and zusanli in rats. J Korean Acupuncture and Moxibustion Society. 2003 ; 20(6) : 89-102
Park HJ, Lyu YH, Hong MS, Kim ST, Im SBN. The effect of HT7 acupuncturing on the food intake and hypothalamic neuropeptide Y expression changed by maternal separation in rat pups. J Korean Acupuncture and Moxibustion Society. 2003 ; 20(4) : 93-101.
Mun HC, Hwang WJ, Lee GM, Cho JW, Oh HH, Byun JY, et al. The nuclear medical study on the effect of LI4 acupucture on cerebral blood flow. J Korean Acupuncture and Moxibustion Society. 2001 ; 18(4) : 46-54.
Lee GM, Hwang YJ, Yang YS, Kim SJ, Lyu DS, Kim MJ, et al. The nuclear medical study on the effect of Hap - Kok (LI4) Acupuncture on cerebral blood flow. J Korean Acupuncture and Moxibustion Society. 2001 ; 18(6) : 93-104.
Lee KW. Pyun Ju Yeok Hae Hwang Je Nae Kyeong (1). Seoul : Yeogang Publishing Company. 2000 : 236.

저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증