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NTIS 바로가기생물정신의학 = Korean journal of biological psychiatry, v.19 no.3, 2012년, pp.134 - 139
김상하 (가톨릭대학교 의과대학 정신건강의학교실) , 전태연 (가톨릭대학교 의과대학 정신건강의학교실)
Objectives : Proinflammatory process has been implicated as an underlying mechanism of bipolar disorder and schizophrenia. Previous studies have suggested a possible role of lymphotoxin alpha (LTA) gene in the development of schizophrenia and have prompted further investigation in bipolar patients. ...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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양극성 장애가 유전적 소인이 중요하다고 판단하는 이유는 무엇인가? | 유전율(heritability)이 80%에 이르는 양극성 장애는 그동안의 많은 가계, 쌍생아 및 양자 연구를 통하여 질병 감수성(susceptibility)을 결정하는 요인 중 유전적 소인이 매우 중요함이 확인 되었다.1)2) 이러한 명백한 유전적 배경에도 불구하고 양극성 장애의 원인적 복잡성 때문에 정확한 신경생물학적인 병인에 대한 탐구는 여전히 계속되고 있다. | |
제1형 양극성 장애가 정신병적 증상과 동반되는 경우 신체에 어떠한 영향을 주며, 무엇을 시사하는가? | 제1형 양극성 장애는 기분 삽화의 재발이 흔하고 약 3분의 1의 환자에서 만성적인 경과를 보이며 심각한 사회적 기능 손상을 야기한다. 특히 양극성 장애 환자에서 정신병적 증상이 동반되는 경우, 병전 저조한 직업 수행 능력, 알코올 의존, 우울 증상, 그리고 성별이 남성인 경우와 더불어 이 질환의 불량한 예후 인자로 작용하고22) 조기 발병의 병력과 함께 질병의 가족성, 더 나아가 유전적 성향을 시사한다.23) 이렇게 정신병적 증상을 동반한 양극성 장애의 경우 특히 정신병적 증상이 mood-incongruent할 때, 양극성 장애 가계 내 군집성을 보이는 점과 조현병의 감수성 유전자좌와의 유의한 연관을 보인 전장유전체 연관분석 결과24)는 양극성 장애 중 특히 정신병적 증상을 동반한 양극성 장애와 조현병이 상당한 유전적 배경을 공유하고 있음에 대한 가능성을 시사한다. | |
양극성 장애의 유전율은 어느정도에 이르는가? | 유전율(heritability)이 80%에 이르는 양극성 장애는 그동안의 많은 가계, 쌍생아 및 양자 연구를 통하여 질병 감수성(susceptibility)을 결정하는 요인 중 유전적 소인이 매우 중요함이 확인 되었다.1)2) 이러한 명백한 유전적 배경에도 불구하고 양극성 장애의 원인적 복잡성 때문에 정확한 신경생물학적인 병인에 대한 탐구는 여전히 계속되고 있다. |
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