본 증례는 충남대학교 수의과대학 부속동물병원에 내원한 심장사상충에 중감염된 2세, 암컷의 진도견에서 혈장 NT-pro BNP농도를 측정하였다. 심장사상충 감염은 신체검사, 혈액검사, ELISA 키트검사 및 영상진단검사 등으로 진단하였다. 본 증례 진도견의 혈장 NT-pro BNP농도는 심장사상충에 감염되지 않고, 다른 질병도 없는 5마리(모두2세, 모두 암컷)의 정상견과 비교하였을 때, 상대적으로 매우 높은 수치를 나타내었다 (정상견 평균: 373 pmol/L, 본 증례: 2,950 pmol/L). 본 연구는 우리가 아는 한 심장사상충에 감염된 진도견에서 혈장 NT-pro BNP농도를 측정하여 보고한 최초의 증례보고이다.
본 증례는 충남대학교 수의과대학 부속동물병원에 내원한 심장사상충에 중감염된 2세, 암컷의 진도견에서 혈장 NT-pro BNP농도를 측정하였다. 심장사상충 감염은 신체검사, 혈액검사, ELISA 키트검사 및 영상진단검사 등으로 진단하였다. 본 증례 진도견의 혈장 NT-pro BNP농도는 심장사상충에 감염되지 않고, 다른 질병도 없는 5마리(모두2세, 모두 암컷)의 정상견과 비교하였을 때, 상대적으로 매우 높은 수치를 나타내었다 (정상견 평균: 373 pmol/L, 본 증례: 2,950 pmol/L). 본 연구는 우리가 아는 한 심장사상충에 감염된 진도견에서 혈장 NT-pro BNP농도를 측정하여 보고한 최초의 증례보고이다.
The aim of this study is to report the observed elevation of plasma N-terminal pro-B-type natriuretic peptide (NT proBNP) concentration in a Korean Jindo Dog infected with Dirofilaria immitis. Evaluation of the animal included physical examination, thoracic radiography, ELISA kit ($PetCheck^{(R...
The aim of this study is to report the observed elevation of plasma N-terminal pro-B-type natriuretic peptide (NT proBNP) concentration in a Korean Jindo Dog infected with Dirofilaria immitis. Evaluation of the animal included physical examination, thoracic radiography, ELISA kit ($PetCheck^{(R)}$, IDEXX Laboratories, USA) test and plasma NT-proBNP evaluation. The infected animal's NT-proBNP concentration was compared with those of 5 normal dogs of the same age, sex, and breed; the affected Korean Jindo dog had increased plasma NT-proBNP. To the best our knowledge, this is the first report of NT-proBNP elevation in a Korean Jindo dog with dirofilariasis.
The aim of this study is to report the observed elevation of plasma N-terminal pro-B-type natriuretic peptide (NT proBNP) concentration in a Korean Jindo Dog infected with Dirofilaria immitis. Evaluation of the animal included physical examination, thoracic radiography, ELISA kit ($PetCheck^{(R)}$, IDEXX Laboratories, USA) test and plasma NT-proBNP evaluation. The infected animal's NT-proBNP concentration was compared with those of 5 normal dogs of the same age, sex, and breed; the affected Korean Jindo dog had increased plasma NT-proBNP. To the best our knowledge, this is the first report of NT-proBNP elevation in a Korean Jindo dog with dirofilariasis.
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문제 정의
The aim of this report is to describe our experience with a Korean Jindo Dog with severe D. immitis infection and elevated plasma NT proBNP.
가설 설정
We hypothesized that NT-proBNP levels would be elevated in dogs with severe dirofilariasis leading to congestive heart failure. Haβdenteufel et al.
제안 방법
A 2-year-old female Korean Jindo dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University in Daejon city, Korea, with a history of respiratory distress, exercise intolerance, and anorexia. Physical examination, urinalysis, and thoracic radiography were conducted, and a blood sample was drawn to assess the complete blood test (VetABC; HESKA, France), blood chemistry profile (Vetscan; Abaxis Inc, Union city, CA, USA), enzyme-linked immunosorbent assay (ELISA) test, and plasma NT-proBNP concentration (Cadiopet proBNP; IDEXX Laboratories Inc., Westbrook, ME, USA).
성능/효과
The dog’s plasma NT-proBNP concentration was 2,960 pmol/L. Five normal Korean Jindo dogs, of the same age and sex, were evaluated and had a mean plasma NT-proBNP concentration of 373 pmol/L (Table 1).
후속연구
immitis infection. Further study is needed to investigate the large scale survey and relationship of plasma NTproBNP concentration to the severity of canine dirofilariasis.
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