[논문]Anti-atopic Effects of the Silkworm Feces Extracts in the NC/Nga Mice

Ju, Wan-Taek; Kim, Hyun-Bok; Kim, Kee-Young; Sung, Gyoo-Byung; Kim, Yong-Soon

doi:10.7852/ijie.2013.27.2.289

[국내논문] Anti-atopic Effects of the Silkworm Feces Extracts in the NC/Nga Mice 원문보기

International journal of industrial entomology, v.27 no.2, 2013년, pp.289 - 297

Ju, Wan-Taek (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science, RDA) , Kim, Hyun-Bok (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science, RDA) , Kim, Kee-Young (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science, RDA) , Sung, Gyoo-Byung (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science, RDA) , Kim, Yong-Soon (Sericultural & Apicultural Materials Division, National Academy of Agricultural Science, RDA)

Abstract ▼ AI-Helper

This study was evaluated the antiatopic activity of silkworm feces extracts in DNCBinduced NC/Nga atopy mice. It was found that each level of IgE and histamine in blood was significantly decreased in the silkworm feces extracts treatment groups, compared with the DNCB-induced atopy control group. When the silkworm feces extracts was applied to the atopy mice, it could be observed that its skin recovered to normal condition with the skin surface being clean and smooth without any tissue. The results suggest that the application of silkworm feces extracts effect on atopic model through a inhibition of histamine emissions with reducing the levels of blood IgE in NC/Nga atopy mice.

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가설 설정

A: Effect of silkworm feces on the levels of serum TNF-α in NC/Nga mice.
A: Effect of silkworm feces on the levels of serum TNF-α in NC/Nga mice. B: The formation of inflammatory cytokine mRNA in skin tissue.

제안 방법

This study evaluated the anti-atopic effects of silkworm feces extracts in DNCB-induced NC/Nga atopic mice in order to obtain basic data for the development of safe and effective atopy treatment compositions or functional cosmetics without side effects.
Twelve weeks after the DNCB spread, silkworm feces extracts suspended in deionized water were prepared at the concentration of 1 mg/mL, 3 mg/mL, and 10 mg/mL, and a 200 μL treatment was applied once a day five days in a row for four weeks.

대상 데이터

Eight-week-old NC/Nga mice were utilized in this study. Seven-week-old mice were purchased from Central Laboratory Animals Co.

데이터처리

The statistical significance was tested via the student’s t test and the histological severity score was tested using ANOVA(one way analysis of variance).

성능/효과

Therefore, the results of this study suggest that silkworm feces extracts can be developed as a raw material for medicines and functional cosmetics that improve the symptoms of atopic dermatitis. However, the component (or combination of components) of the tested silkworm feces extracts that is effective in relieving the symptoms of atopic dermatitis is yet to be determined.

후속연구

Therefore, further studies need to be performed to identify the effective components that improve atopic dermatitis symptoms and their mechanisms of action.

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