[논문]Correlation between Low Gleason Score and Prostate Specific Antigen Levels with Incidence of Bone Metastases in Prostate Cancer Patients: When to Omit Bone Scans?

Sanjaya, I. Putu Gde; Mochtar, Chaidir Arief; Umbas, Rainy

doi:10.7314/apjcp.2013.14.9.4973

Correlation between Low Gleason Score and Prostate Specific Antigen Levels with Incidence of Bone Metastases in Prostate Cancer Patients: When to Omit Bone Scans? 원문보기

Asian Pacific journal of cancer prevention : APJCP, v.14 no.9, 2013년, pp.4973 - 4976

Sanjaya, I. Putu Gde (Department of Urology, Cipto Mangunkusumo Hospital, University of Indonesia) , Mochtar, Chaidir Arief (Department of Urology, Cipto Mangunkusumo Hospital, University of Indonesia) , Umbas, Rainy (Department of Urology, Cipto Mangunkusumo Hospital, University of Indonesia)

Abstract ▼ AI-Helper

Background: To identify correlation and incidence of bone metastases in prostate cancer patient with low Gleason scores (GS) and prostate specific antigen (PSA) levels. Materials and Methods: This descriptive restrospective study covered patients with prostate cancer in Cipto Mangunkusumo Hospital in 2006-2011. Of a total of 478, those who had PSA values, histological examination, and bone scan were included, resulting in 358 eligible cases. PSA values were measured using the sandwich electrochemiluminescent immunoassay. Histological examination was graded according to Gleason's grading system and divided into 3 categories: well differentiated ($GS{\leq}6$), moderately differentiated (GS 7) and poorly differentiated (GS 8-10). Bone scans were performed using a radiopharmaceutical agent ($T_c$ 99m methylenen diphosphonate) with images captured by gamma camera. Results: The mean age was $67.5{\pm}7.8$, mean GS was $7.7{\pm}1.3$ and median PSA was 56.9 (range: 0.48-17000 ng/mL). There were 11 patients (3.0%) with positive bone scan with PSA<20 ng/mL and GS<8. Furthermore, there were 2 patients (0.6%) with $GS{\leq}6$ and PSA<10 ng/mL showing bone metastasis. Conclusions: In our study, there were still small percentage of patients with bone metastasis even when low values of PSA (PSA<10 ng/mL) and GS ($GS{\leq}6$) were applied.

주제어

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문제 정의

The purpose of the current study was to identify and correlate the incidence of BM in low PSA and GS in prostate cancer patients in Indonesian population. Furthermore, evaluating the recommendation of international urology consensus of prostate cancer’s patient selection to undergone BS.
This study was a retrospective study of patients diagnosed with prostate cancer in Cipto Mangunkusumo hospital in 2006-2011. Data were collected from the medical records of the patients.

제안 방법

Limitation of the study was no adequate follow up to the patients with metastatic bone disease in prostate cancer patients with low PSA and GS and this study did not investigate other variables that could predict BM such as: alkaline phosphatase and bony symptoms.
Recorded data were PSA value, histopathological examination of prostate’s tissue, and bone scan result.

이론/모형

PSA value was measured using the sandwich electrochemiluminescent immunoassay technique. The PSA value in the study was divided into 5 categories:<10 ng/mL, 10 to ≤20 ng/mL, 20 to ≤50 ng/mL, 50 to ≤100 ng/mL, and >100 ng/mL.

성능/효과

In conclusion, there was high incidence of BM in newly diagnosed PC in our study (53.6%) compared to other studies; PSA and GS positively related to the incidence of BM; and there were still small number of patients had BM with low GS and PSA.

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