Tural, Deniz
(Akdeniz University, Medical Faculty, Department of Internal Medicine, Division of Medical Oncology)
,
Elicin, Olgun
(Department of Radiation Oncology, Division of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty)
,
Batur, Sebnem
(Department of Pathology, Division of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty)
,
Arslan, Deniz
(Akdeniz University, Medical Faculty, Department of Internal Medicine, Division of Medical Oncology)
,
Oz, Buge
(Department of Pathology, Division of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty)
,
Serdengecti, Suheyla
(Department of Internal Medicine, Division of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty)
,
Uzel, Omer
(Akdeniz University, Medical Faculty, Department of Internal Medicine, Division of Medical Oncology)
Background: Primary aim of this study is to assess whether or not there is an increase at rate of HPV positive oropharyngeal cancers during 1996-2011 in Turkey, for comparison with prior reports from Western countries. Materials and Methods: A total of 138 newly diagnosed patients with oropharyngeal...
Background: Primary aim of this study is to assess whether or not there is an increase at rate of HPV positive oropharyngeal cancers during 1996-2011 in Turkey, for comparison with prior reports from Western countries. Materials and Methods: A total of 138 newly diagnosed patients with oropharyngeal cancer were identified, 39 of which had no primary tumor specimen available and 18 patients with invalid HPV status, therefore HPV status for remaining 81 patients was evaluated. The presence and type of HPV DNA were determined with formalin-fixed paraffin embedded specimens, using an HPV DNA-based multiplex PCR assay. Associations between HPV status and clinicopathological characteristics were evaluated using a two-sample t-test for the continuous variables and the categorical variables were compared by chi-square test. Overall survival (OS) periods were calculated with Kaplan-Meier method. Results: The proportion of HPV-positive cancer has continued to increase during 2004-2011 as compared with 1996-2003. Notably, 33% (6/18) of the cases were HPV-positive in 1996-1999, 43% (9/21) in 2000-2003, 55% (11/20) in 2004-2007 and 70% (16/23) in 2008-2011. Thus, when we compared the results obtained during the 2004-2011with results of 1996-2003 period, we found that increase at HPV-positivity ratio was statistically significant (38% vs 64% p=0.012). Conclusions: This study demonstrated that HPV positive oropharyngeal cancers are increasing in Turkish patients as in the Western world.
Background: Primary aim of this study is to assess whether or not there is an increase at rate of HPV positive oropharyngeal cancers during 1996-2011 in Turkey, for comparison with prior reports from Western countries. Materials and Methods: A total of 138 newly diagnosed patients with oropharyngeal cancer were identified, 39 of which had no primary tumor specimen available and 18 patients with invalid HPV status, therefore HPV status for remaining 81 patients was evaluated. The presence and type of HPV DNA were determined with formalin-fixed paraffin embedded specimens, using an HPV DNA-based multiplex PCR assay. Associations between HPV status and clinicopathological characteristics were evaluated using a two-sample t-test for the continuous variables and the categorical variables were compared by chi-square test. Overall survival (OS) periods were calculated with Kaplan-Meier method. Results: The proportion of HPV-positive cancer has continued to increase during 2004-2011 as compared with 1996-2003. Notably, 33% (6/18) of the cases were HPV-positive in 1996-1999, 43% (9/21) in 2000-2003, 55% (11/20) in 2004-2007 and 70% (16/23) in 2008-2011. Thus, when we compared the results obtained during the 2004-2011with results of 1996-2003 period, we found that increase at HPV-positivity ratio was statistically significant (38% vs 64% p=0.012). Conclusions: This study demonstrated that HPV positive oropharyngeal cancers are increasing in Turkish patients as in the Western world.
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문제 정의
In western country the incidence of HPV related oropharyngeal cancer increased. Primary aim of this study is to assess whether or not there is an increase at rate of HPV positive oropharyngeal cancers during 1996-2011 in the Turkey, in comparison with prior reports in western countries.
제안 방법
The main limitation of this study is that the study includes small size of patients. Despite these limitations, this study demonstrated that HPV positive oropharyngeal cancers increased in Turkish patients same as western countries.
데이터처리
Associations between HPV status and clinicopathological characteristics were evaluated by using a two-sample t-test for the continuous variables and categorical variables were compared by using chisquare test. HPV status were calculated for 2-year period and from 1996-2003 to 2004-2011.
이론/모형
HPV status were calculated for 2-year period and from 1996-2003 to 2004-2011. Overall survival (OS) periods were calculated with Kaplan-Meier method. All analyses were performed using the Statistical Package for the Social Sciences (SPSS) version 15.
성능/효과
Five patients and 1 patient were confirmed as HPV18 (12%) and HPV33 (2%) by multiplex PCR, respectively. Comparing the results obtained during 2004-2011period with results for 1996-2003 period, we found that median age decreased (55.4 vs 61.2, p=0.015), tonsillar subside of oropharyngeal squamous cell carcinoma increased (52% vs 39%, p=0.01), poor tumor histology ratio increased (42% vs 34%, p=0.04) and rate of patients who smokes decreased (33% vs 58%, p=0.02) (Table 1). The proportion of HPV-positive cancer has continued to increase during 2004-2011 as compared with 1996-2003.
This study confirmed that the rate of HPV-positive oropharyngeal squamous cancer in the Turkey increased during 1996-2011 period. We have been demonstrated a continuous increase in the proportion of HPV positive oropharyngeal squamous cancer from 1996-1999 period (33%) to 2008-2011 period (70%).
참고문헌 (15)
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