Luo, Zhao-Yun
(Central Laboratory, Chaozhou Central Hospital)
,
Chen, Qiang
(Central Laboratory, Chaozhou Central Hospital)
,
Yang, Hui
(Central Laboratory, Chaozhou Central Hospital)
,
Lin, Min
(Central Laboratory, Chaozhou Central Hospital)
,
Chen, Chan-Yu
(Department of Gynecology and Obstetrics, Chaozhou Central Hospital)
,
Yang, Chun
(Department of Gynecology and Obstetrics, Chaozhou Central Hospital)
,
Yang, Li-Ye
(Central Laboratory, Chaozhou Central Hospital)
Background: Low-risk human papillomavirus (LR-HPV) infection is the main cause of genital warts. LRHPV genotypes 6 and 11 are associated with genital warts, but there have only been a few published studies about the genotype-specific prevalence of HPV in genital warts in China. The objective of our ...
Background: Low-risk human papillomavirus (LR-HPV) infection is the main cause of genital warts. LRHPV genotypes 6 and 11 are associated with genital warts, but there have only been a few published studies about the genotype-specific prevalence of HPV in genital warts in China. The objective of our study was to assess the prevalence of HPV genotypes for clinical cases involving both men and women and to evaluate the potential benefit of a quadrivalent (genotypes 6, 11, 16, and 18) HPV vaccine in eastern Guangdong province of China. Materials and Methods: A total of 696 eligible patients with genital warts were enrolled during the period Aug 2009 through Oct 2014. Specimens were collected from genital warts, the HPV GenoArray test was used for HPV detection and genotyping, which could detect 21 HPV genotypes, including genotypes 6, 11, 16, and 18. Results: Among the 696 cases, 675 samples were successfully genotyped. The median age of patients was 32.1 years (range, 16-67 years). The most prevalent genotypes were HPV-6 (285/675, 42.2%), HPV-11 (265/675, 39.3%), HPV-52 (52/675, 7.7%), HPV-16 (51/675, 7.56%), HPV-81 (50/675, 7.40%) and HPV-58 (37/675, 5.48%). Low-risk genotypes predominated, with a prevalence of 96.59%. The cumulative prevalence of genotypes 6 and 11 was 78.7% (531/675), the cumulative prevalence of genotypes 16 and 18 was 11.6% (78/675), and the cumulative prevalence of genotypes 6, 11, 16, and 18 was 82.5% (557/675). Conclusions: Our results provide strong evidence that, in eastern Guangdong, different from Western countries, the most prevalent low risk HPV genotypes in patients with genital warts are 6, 11 and 81. The quadrivalent HPV vaccine could prevent 82.5% of genital warts in eastern Guangdong.
Background: Low-risk human papillomavirus (LR-HPV) infection is the main cause of genital warts. LRHPV genotypes 6 and 11 are associated with genital warts, but there have only been a few published studies about the genotype-specific prevalence of HPV in genital warts in China. The objective of our study was to assess the prevalence of HPV genotypes for clinical cases involving both men and women and to evaluate the potential benefit of a quadrivalent (genotypes 6, 11, 16, and 18) HPV vaccine in eastern Guangdong province of China. Materials and Methods: A total of 696 eligible patients with genital warts were enrolled during the period Aug 2009 through Oct 2014. Specimens were collected from genital warts, the HPV GenoArray test was used for HPV detection and genotyping, which could detect 21 HPV genotypes, including genotypes 6, 11, 16, and 18. Results: Among the 696 cases, 675 samples were successfully genotyped. The median age of patients was 32.1 years (range, 16-67 years). The most prevalent genotypes were HPV-6 (285/675, 42.2%), HPV-11 (265/675, 39.3%), HPV-52 (52/675, 7.7%), HPV-16 (51/675, 7.56%), HPV-81 (50/675, 7.40%) and HPV-58 (37/675, 5.48%). Low-risk genotypes predominated, with a prevalence of 96.59%. The cumulative prevalence of genotypes 6 and 11 was 78.7% (531/675), the cumulative prevalence of genotypes 16 and 18 was 11.6% (78/675), and the cumulative prevalence of genotypes 6, 11, 16, and 18 was 82.5% (557/675). Conclusions: Our results provide strong evidence that, in eastern Guangdong, different from Western countries, the most prevalent low risk HPV genotypes in patients with genital warts are 6, 11 and 81. The quadrivalent HPV vaccine could prevent 82.5% of genital warts in eastern Guangdong.
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대상 데이터
Chaozhou City located in easternmost Guangdong province of the People’s Republic of China. From August 2009 to October 2014, the study was carried out in Chaozhou Central Hospital. The initial diagnosis of genital warts was made by gynaecologist, dermatologist, or urologist.
, Chaozhou, China. The study was carried out with the approval of the ethical committee of Chaozhou Central Hospital, and patients consent was obtained for the collection of samples.
The subjects of our study was carried out in Chaozhou Central Hospital and most of them were natives. The initial diagnosis of genital warts was made by gynaecologist, dermatologist, or urologist.
데이터처리
25 by Microsoft Excel software. Chi-squared tests were used to assess the statistical significance of any differences in prevalence. All data were analyzed using SPSS software version 16.
이론/모형
, 2012b). HPV GenoArray test was used for HPV detection and genotyping. Genotyping was done by DNA amplification, flow-through hybridization and gene chip by HybriMax (Hybribio Biotechnology Limited Corp.
성능/효과
This demonstrated that HPV 81 was more prone to induce epithelial lesion (genital warts) in women other than in males, another explanation was that HPV81 could be eliminated by males quickly, the mechanism underlining it was not clear yet. According to the published data, our study is the first to report the presence of 81 as a single HPV genotype in genital warts tissue specimens, giving this particular HPV genotype a more prominent place in the etiopathogenesis of genital warts than was supposed before.
In conclusion, our study showed that HPV can be found in virtually all tissue specimens of genital warts obtained from patients in eastern Guangdong. This finding suggests that, if the recently approved quadrivalent HPV vaccine proves to be as effective in preventing HPV infections in males as it has proved in females (Brown et al.
, 2012b). This study showed that HPV subtypes infection of genital warts of our area were mainly low risk HPV11 and HPV6, consistent to previous study (Chan et al., 2009; Cremin et al., 2012), possibly due to common warts sample of genitals.
후속연구
, 2012). In this study, we would like to present the distribution of HPV types in genital warts of a cohort of Chinese in Guangdong to contribute essential data for assessing the potential benefit of HPV vaccines containing HPV 6 and 11.
참고문헌 (16)
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