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NTIS 바로가기대한구강내과학회지 = Korean journal of oral medicine, v.38 no.1, 2013년, pp.87 - 95
Osteoarthritis (OA) of the temporomandibular joint (TMJ) is a severe form of temporomandibular disorders (TMDs), presenting gradual breakdown of articular cartilage and subchondral bone by the functional load sustained to exceed the physiologic tolerance of the joint. In such a joint loaded, offensi...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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염증성 cytokine 발현을 촉진하는 것은? | 관절에 가해지는 물리적 부하는 연골세포를 자극 하여 염증성 cytokine의 발현을 촉진하는데, 많은 연구들이 골관절염이 발생한 측두하악관절의 관절활액 내에서 대조군보다 높은 농도의 염증성 cytokine을 관찰할 수 있다고 보고하고 있는 점이 이를 뒷받침한다.7,9,24,25)또한, 인간 활막세포를 배양하여 압력을 가하였을 때 MMP-2, -3와 함께 IL-8의 유전자 발현이 증가하는 사실을 보고한 연구가 있있고,26)돼지의 관절에 압력을 가한 뒤 연골세포를 배양하는 연구를 통해 type II collagen, aggrecan, type X collagen의 mRNA 발현이 감소한다는 사실을 보고한 바도 있다. | |
골관절염은 어떤 관절에서 발생하는가? | 골관절염은 관절에 가해지는 물리적 부하가 관절 연골의 생리적인 내성을 초과할 때 발생하는 관절연골 및 연골하방 골조직의 변성과 파괴 및 이차적 염증을 특징으로 하는 관절 질환이다. 대개 지속적인 하중을 견뎌야하는 엉덩이 관절이나 무릎 관절에 흔하지만 손가락 마디, 척추 등 작은 관절에서도 발생한다. 지속적인 물리적 부하가 질환의 발생에 가장 큰 요인이며 여성에서 호발하고 45세 이후에 급격한 유병율의 증가를 보이는 것으로 알려져 있다. | |
측두하악관절 골관절염이란? | 측두하악관절 골관절염은 측두하악장애의 한 형태로 관절조직의 생리적 내성을 초과하는 기능적 부하가 지속적으로 관절에 가해졌을 때 관절연골 및 연골하 골조직의 점진적 파괴와 이차적 염증을 특징으로 하는 질환이다. 관절면에 가해지는 물리적 하중은 관절내에서 기질파괴 단백효소나 염증성 cytokine, 유리기의 활성을 증가시키고, 그에 따라 골조직의 퇴행과 재형성 사이의 균형을 깨뜨려 골조직의 흡수를 야기한다. |
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