무균성수막염과 뇌염환자 사이의 인구학과 검사소견의 비교: 나이와 C-반응단백질의 중요성 Comparison of the Demographic and Laboratory Profiles of Patients with Aseptic Meningitis and Encephalitis: Significance of Age and C-reactive Protein원문보기
Background: Viruses can cause either meningitis or encephalitis. It is unclear why some people suffer from aseptic meningitis, and others acquire aseptic encephalitis when infected with the same viral pathogens. The aim of this study was to compare demographic and laboratory factors between patients...
Background: Viruses can cause either meningitis or encephalitis. It is unclear why some people suffer from aseptic meningitis, and others acquire aseptic encephalitis when infected with the same viral pathogens. The aim of this study was to compare demographic and laboratory factors between patients with aseptic meningitis and encephalitis. Methods: The demographic and laboratory differences were analyzed according to age, sex, diabetes, hypertension, C-reactive protein in the blood, white blood cell and protein in the cerebrospinal fluid, and glucose ratio (cerebrospinal fluid/blood). Additionally, we analyzed the nation-wide differencesin age between the patients with aseptic meningitis and those with encephalitis in Korea. Results: The patients with aseptic encephalitis were older, more likely to have hypertension, and had higher levels of C-reactive protein than did the patients with aseptic meningitis. However, the numbers of white blood cells in the cerebrospinal fluid were significantly higher in the patients with meningitis than in the patients with encephalitis. Multivariable analysis revealed that age >49 years, hypertension and a C-reactive protein level >5.81 mg/dL were independent and significant variables in the prediction of aseptic encephalitis. Additionally, the patients with aseptic encephalitis were older than those with aseptic meningitis in the nation-wide Korean database. Conclusions: Older age, hypertension, and higher levels of C-reactive protein are useful factors for the prediction of aseptic encephalitis.
Background: Viruses can cause either meningitis or encephalitis. It is unclear why some people suffer from aseptic meningitis, and others acquire aseptic encephalitis when infected with the same viral pathogens. The aim of this study was to compare demographic and laboratory factors between patients with aseptic meningitis and encephalitis. Methods: The demographic and laboratory differences were analyzed according to age, sex, diabetes, hypertension, C-reactive protein in the blood, white blood cell and protein in the cerebrospinal fluid, and glucose ratio (cerebrospinal fluid/blood). Additionally, we analyzed the nation-wide differencesin age between the patients with aseptic meningitis and those with encephalitis in Korea. Results: The patients with aseptic encephalitis were older, more likely to have hypertension, and had higher levels of C-reactive protein than did the patients with aseptic meningitis. However, the numbers of white blood cells in the cerebrospinal fluid were significantly higher in the patients with meningitis than in the patients with encephalitis. Multivariable analysis revealed that age >49 years, hypertension and a C-reactive protein level >5.81 mg/dL were independent and significant variables in the prediction of aseptic encephalitis. Additionally, the patients with aseptic encephalitis were older than those with aseptic meningitis in the nation-wide Korean database. Conclusions: Older age, hypertension, and higher levels of C-reactive protein are useful factors for the prediction of aseptic encephalitis.
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문제 정의
The aim of this study was to compare the demographic and laboratory profiles of patients with aseptic meningitis and encephalitis.
제안 방법
All patients underwent tests that included PCR of the CSF/serum to identify of viral pathogens such as Epstein-Barr virus, varicella zoster virus, herpes simplex virus, cytomegalovirus, and enterovirus. The primary endpoint of this study was the diagnosis of aseptic encephalitis or meningitis.
The demographic and laboratory differences were analyzed with age, sex, diabetes, hypertension, C-reactive protein (CRP) in the blood, white blood cells (WBCs) and protein in the cerebrospinal fluid (CSF), and glucose ratio (CSF/blood) as independent variables. If there were multiple CSF profile and CRP measurements, we analyzed the first CSF profiles and CRP measurements that were obtained on the day of admission.
All patients underwent tests that included PCR of the CSF/serum to identify of viral pathogens such as Epstein-Barr virus, varicella zoster virus, herpes simplex virus, cytomegalovirus, and enterovirus. The primary endpoint of this study was the diagnosis of aseptic encephalitis or meningitis. The demographic and laboratory differences were analyzed with age, sex, diabetes, hypertension, C-reactive protein (CRP) in the blood, white blood cells (WBCs) and protein in the cerebrospinal fluid (CSF), and glucose ratio (CSF/blood) as independent variables.
대상 데이터
Of the 155 patients, 107 patients satisfied the inclusion and exclusion criteria for this study. Sixty five patients were men and 42 patients were women. The mean age was 35.
데이터처리
We analyzed the categorical clinical variables using Fisher’s exact test or the chi-square test, and used Student’s t-test or the Mann–Whitney U-test for numerical variables.
성능/효과
In conclusion, we demonstrated that age of onset (>49 years), hypertension, and higher CRP levels (>5.81 mg/dL) were independent and significant variables in the prediction of aseptic encephalitis.
Third, because we used only the ICD-10 codes to determine the nation –wide incidences of aseptic meningitis and encephalitis, the diagnoses might be not accurate.
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