최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Genomics & informatics, v.12 no.4, 2014년, pp.195 - 202
Shim, Unjin (Department of Internal Medicine, Seoul Seonam Hospital, Ewha Womans University Medical Center) , Kim, Han-Na (Department of Biochemistry, Ewha Womans University School of Medicine) , Sung, Yeon-Ah (Department of Internal Medicine, Ewha Womans University School of Medicine) , Kim, Hyung-Lae (Department of Biochemistry, Ewha Womans University School of Medicine)
Metabolic syndrome (MetS) is a complex disorder related to insulin resistance, obesity, and inflammation. Genetic and environmental factors also contribute to the development of MetS, and through genome-wide association studies (GWASs), important susceptibility loci have been identified. However, GW...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
1 de Carvalho Vidigal F Bressan J Babio N Salas-Salvadó J Prevalence of metabolic syndrome in Brazilian adults: a systematic review BMC Public Health 2013 13 1198 24350922
2 Márquez-Sandoval F Macedo-Ojeda G Viramontes-Hörner D Fernández Ballart JD Salas Salvadó J Vizmanos B The prevalence of metabolic syndrome in Latin America: a systematic review Public Health Nutr 2011 14 1702 1713 21486521
3 Aguilera CM Olza J Gil A Genetic susceptibility to obesity and metabolic syndrome in childhood Nutr Hosp 2013 28 Suppl 5 44 55 24010743
4 Hoang KC Le TV Wong ND The metabolic syndrome in East Asians J Cardiometab Syndr 2007 2 276 282 18059211
5 Nestel P Lyu R Low LP Sheu WH Nitiyanant W Saito I Metabolic syndrome: recent prevalence in East and Southeast Asian populations Asia Pac J Clin Nutr 2007 16 362 367 17468095
6 Whitaker RC Wright JA Pepe MS Seidel KD Dietz WH Predicting obesity in young adulthood from childhood and parental obesity N Engl J Med 1997 337 869 873 9302300
7 Whitaker RC Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy Pediatrics 2004 114 e29 e36 15231970
8 Ristow M Müller-Wieland D Pfeiffer A Krone W Kahn CR Obesity associated with a mutation in a genetic regulator of adipocyte differentiation N Engl J Med 1998 339 953 959 9753710
9 Peters KE Beilby J Cadby G Warrington NM Bruce DG Davis WA A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome BMC Med Genet 2013 14 15 23351195
10 Joy T Lahiry P Pollex RL Hegele RA Genetics of metabolic syndrome Curr Diab Rep 2008 8 141 148 18445357
11 Fall T Ingelsson E Genome-wide association studies of obesity and metabolic syndrome Mol Cell Endocrinol 2014 382 740 757 22963884
12 Vimaleswaran KS Tachmazidou I Zhao JH Hirschhorn JN Dudbridge F Loos RJ Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI Hum Mol Genet 2012 21 4537 4542 22791748
13 Kristiansson K Perola M Tikkanen E Kettunen J Surakka I Havulinna AS Genome-wide screen for metabolic syndrome susceptibility loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits Circ Cardiovasc Genet 2012 5 242 249 22399527
14 Kim YJ Go MJ Hu C Hong CB Kim YK Lee JY Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits Nat Genet 2011 43 990 995 21909109
15 Lee BY Shin DH Cho S Seo KS Kim H Genome-wide analysis of copy number variations reveals that aging processes influence body fat distribution in Korea Associated Resource (KARE) cohorts Hum Genet 2012 131 1795 1804 22825314
16 Cho YS Go MJ Kim YJ Heo JY Oh JH Ban HJ A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits Nat Genet 2009 41 527 534 19396169
17 Hirschhorn JN Daly MJ Genome-wide association studies for common diseases and complex traits Nat Rev Genet 2005 6 95 108 15716906
18 de Bakker PI Yelensky R Pe 'er I, Gabriel SB, Daly MJ, Altshuler D. Efficiency and power in genetic association studies Nat Genet 2005 37 1217 1223 16244653
19 Cantor RM Lange K Sinsheimer JS Prioritizing GWAS results: a review of statistical methods and recommendations for their application Am J Hum Genet 2010 86 6 22 20074509
20 Teo YY Common statistical issues in genome-wide association studies: a review on power, data quality control, genotype calling and population structure Curr Opin Lipidol 2008 19 133 143 18388693
21 Stringer S Wray NR Kahn RS Derks EM Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes PLoS One 2011 6 e27964 22140493
22 Zeggini E Scott LJ Saxena R Voight BF Marchini JL Hu T Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes Nat Genet 2008 40 638 645 18372903
23 Barrett JC Hansoul S Nicolae DL Cho JH Duerr RH Rioux JD Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease Nat Genet 2008 40 955 962 18587394
24 Ramanan VK Shen L Moore JH Saykin AJ Pathway analysis of genomic data: concepts, methods, and prospects for future development Trends Genet 2012 28 323 332 22480918
25 Wang K Li M Hakonarson H Analysing biological pathways in genome-wide association studies Nat Rev Genet 2010 11 843 854 21085203
26 Shahbaba B Shachaf CM Yu Z A pathway analysis method for genome-wide association studies Stat Med 2012 31 988 1000 22302470
27 Segrè AV Groop L Mootha VK Daly MJ DIAGRAM Consortium MAGIC investigators Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits PLoS Genet 2010 6 e1001058 20714348
28 Morris AP Voight BF Teslovich TM Ferreira T Segrè AV Steinthorsdottir V Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes Nat Genet 2012 44 981 990 22885922
29 Speliotes EK Willer CJ Berndt SI Monda KL Thorleifsson G Jackson AU Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Nat Genet 2010 42 937 948 20935630
30 National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report Circulation 2002 106 3143 3421 12485966
31 Grundy SM Cleeman JI Daniels SR Donato KA Eckel RH Franklin BA Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement Circulation 2005 112 2735 2752 16157765
32 Purcell S Neale B Todd-Brown K Thomas L Ferreira MA Bender D PLINK: a tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 2007 81 559 575 17701901
33 Zhai G Teumer A Stolk L Perry JR Vandenput L Coviello AD Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms PLoS Genet 2011 7 e1002025 21533175
34 Heo SG Hwang JY Uhmn S Go MJ Oh B Lee JY Male-specific genetic effect on hypertension and metabolic disorders Hum Genet 2014 133 311 319 24142389
35 Baik I Cho NH Kim SH Han BG Shin C Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men Am J Clin Nutr 2011 93 809 816 21270382
36 Frayling TM Timpson NJ Weedon MN Zeggini E Freathy RM Lindgren CM A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 2007 316 889 894 17434869
37 Kraja AT Vaidya D Pankow JS Goodarzi MO Assimes TL Kullo IJ A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium Diabetes 2011 60 1329 1339 21386085
38 Avery CL He Q North KE Ambite JL Boerwinkle E Fornage M A phenomics-based strategy identifies loci on APOC1 , BRAP , and PLCG1 associated with metabolic syndrome phenotype domains PLoS Genet 2011 7 e1002322 22022282
39 Ren J Pulakat L Whaley-Connell A Sowers JR Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease J Mol Med (Berl) 2010 88 993 1001 20725711
40 Kim JA Wei Y Sowers JR Role of mitochondrial dysfunction in insulin resistance Circ Res 2008 102 401 414 18309108
41 Patti ME Butte AJ Crunkhorn S Cusi K Berria R Kashyap S Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 Proc Natl Acad Sci U S A 2003 100 8466 8471 12832613
42 Ritov VB Menshikova EV He J Ferrell RE Goodpaster BH Kelley DE Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes Diabetes 2005 54 8 14 15616005
43 Kelley DE He J Menshikova EV Ritov VB Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes Diabetes 2002 51 2944 2950 12351431
44 Adams PL Turnbull DM Disorders of the electron transport chain J Inherit Metab Dis 1996 19 463 469 8884570
45 Choksi KB Boylston WH Rabek JP Widger WR Papaconstantinou J Oxidatively damaged proteins of heart mitochondrial electron transport complexes Biochim Biophys Acta 2004 1688 95 101 14990339
46 Harper L Kashiwagi Y Pusey CD Hendry BM Domin J Platelet-derived growth factor reorganizes the actin cytoskeleton through 3-phosphoinositide-dependent and 3-phosphoinositide-independent mechanisms in human mesangial cells Nephron Physiol 2007 107 p45 p56 17804914
47 Carmeliet P Angiogenesis in health and disease Nat Med 2003 9 653 660 12778163
48 Zymek P Bujak M Chatila K Cieslak A Thakker G Entman ML The role of platelet-derived growth factor signaling in healing myocardial infarcts J Am Coll Cardiol 2006 48 2315 2323 17161265
49 Fan B Ma L Li Q Wang L Zhou J Wu J Role of PDGFs/PDGFRs signaling pathway in myocardial fibrosis of DOCA/salt hypertensive rats Int J Clin Exp Pathol 2014 7 16 27 24427322
50 Tisato V Toffoli B Monasta L Bernardi S Candido R Zauli G Patients affected by metabolic syndrome show decreased levels of circulating platelet derived growth factor (PDGF)-BB Clin Nutr 2013 32 259 264 22840561
51 Bessa SS Hussein TA Morad MA Amer AM Urinary platelet-derived growth factor-BB as an early marker of nephropathy in patients with type 2 diabetes: an Egyptian study Ren Fail 2012 34 670 675 22486214
52 Murdolo G Bartolini D Tortoioli C Piroddi M Iuliano L Galli F Lipokines and oxysterols: novel adipose-derived lipid hormones linking adipose dysfunction and insulin resistance Free Radic Biol Med 2013 65 811 820 23954331
53 Bost F Aouadi M Caron L Binétruy B The role of MAPKs in adipocyte differentiation and obesity Biochimie 2005 87 51 56 15733737
54 Gehart H Kumpf S Ittner A Ricci R MAPK signalling in cellular metabolism: stress or wellness? EMBO Rep 2010 11 834 840 20930846
55 Azhar S Peroxisome proliferator-activated receptors, metabolic syndrome and cardiovascular disease Future Cardiol 2010 6 657 691 20932114
56 Corzo C Griffin PR Targeting the peroxisome proliferatoractivated receptor-gamma to counter the inflammatory milieu in obesity Diabetes Metab J 2013 37 395 403 24404510
57 Vänttinen M Nuutila P Kuulasmaa T Pihlajamäki J Hällsten K Virtanen KA Single nucleotide polymorphisms in the peroxisome proliferator-activated receptor delta gene are associated with skeletal muscle glucose uptake Diabetes 2005 54 3587 3591 16306381
58 Hu C Jia W Fang Q Zhang R Wang C Lu J Peroxisome proliferator-activated receptor (PPAR) delta genetic polymorphism and its association with insulin resistance index and fasting plasma glucose concentrations in Chinese subjects Diabet Med 2006 23 1307 1312 17116180
59 Aberle J Hopfer I Beil FU Seedorf U Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V Int J Obes (Lond) 2006 30 1709 1713 16652134
60 Scott LJ Mohlke KL Bonnycastle LL Willer CJ Li Y Duren WL A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 2007 316 1341 1345 17463248
61 Shin HD Park BL Kim LH Jung HS Cho YM Moon MK Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity Diabetes 2004 53 847 851 14988273
62 Tang X Tang G Ozcan S Role of microRNAs in diabetes Biochim Biophys Acta 2008 1779 697 701 18655850
63 Poy MN Spranger M Stoffel M microRNAs and the regulation of glucose and lipid metabolism Diabetes Obes Metab 2007 9 Suppl 2 67 73 17919180
64 Ramírez CM Goedeke L Fernández-Hernando C "Micromanaging" metabolic syndrome Cell Cycle 2011 10 3249 3252 21946517
65 Heneghan HM Miller N Kerin MJ Role of microRNAs in obesity and the metabolic syndrome Obes Rev 2010 11 354 361 19793375
66 Esau C Davis S Murray SF Yu XX Pandey SK Pear M miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting Cell Metab 2006 3 87 98 16459310
67 Gharipour M Sadeghi M Pivotal role of microRNA-33 in metabolic syndrome: a systematic review ARYA Atheroscler 2013 9 372 376 24575141
68 Wang PW Lin TK Weng SW Liou CW Mitochondrial DNA variants in the pathogenesis of type 2 diabetes - relevance of asian population studies Rev Diabet Stud 2009 6 237 246 20043036
69 Mercer JR Cheng KK Figg N Gorenne I Mahmoudi M Griffin J DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome Circ Res 2010 107 1021 1031 20705925
70 Weng SW Liou CW Lin TK Wei YH Lee CF Eng HL Association of mitochondrial deoxyribonucleic acid 16189 variant (T->C transition) with metabolic syndrome in Chinese adults J Clin Endocrinol Metab 2005 90 5037 5040 15972579
71 Liou CW Lin TK Huei Weng H Lee CF Chen TL Wei YH A common mitochondrial DNA variant and increased body mass index as associated factors for development of type 2 diabetes: additive effects of genetic and environmental factors J Clin Endocrinol Metab 2007 92 235 239 17032725
72 Poulton J Brown MS Cooper A Marchington DR Phillips DI A common mitochondrial DNA variant is associated with insulin resistance in adult life Diabetologia 1998 41 54 58 9498630
73 Blasiak J Arabski M Krupa R Wozniak K Zadrozny M Kasznicki J DNA damage and repair in type 2 diabetes mellitus Mutat Res 2004 554 297 304 15450427
74 Cabré A Lázaro I Girona J Manzanares JM Marimón F Plana N Fatty acid binding protein 4 is increased in metabolic syndrome and with thiazolidinedione treatment in diabetic patients Atherosclerosis 2007 195 e150 e158 17553506
75 Cabré A Lázaro I Girona J Manzanares JM Marimón F Plana N Plasma fatty acid-binding protein 4 increases with renal dysfunction in type 2 diabetic patients without microalbuminuria Clin Chem 2008 54 181 187 18024526
76 Mahdi T Hänzelmann S Salehi A Muhammed SJ Reinbothe TM Tang Y Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes Cell Metab 2012 16 625 633 23140642
77 Qi Q Yu Z Ye X Zhao F Huang P Hu FB Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people J Clin Endocrinol Metab 2007 92 4827 4834 17878249
78 Liu Y Wang D Li D Sun R Xia M Associations of retinol-binding protein 4 with oxidative stress, inflammatory markers, and metabolic syndrome in a middle-aged and elderly Chinese population Diabetol Metab Syndr 2014 6 25 24559154
79 Zhang G Beati H Nilsson J Wodarz A The Drosophila microtubule-associated protein mars stabilizes mitotic spindles by crosslinking microtubules through its N-terminal region PLoS One 2013 8 e60596 23593258
80 Kelder T Conklin BR Evelo CT Pico AR Finding the right questions: exploratory pathway analysis to enhance biological discovery in large datasets PLoS Biol 2010 8 e1000472 20824171
81 Khatri P Sirota M Butte AJ Ten years of pathway analysis: current approaches and outstanding challenges PLoS Comput Biol 2012 8 e1002375 22383865
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.