Gastritis is a major disease that has the potential to grow as gastric cancer. Gastric cancer is a very common cancer, and it is related to a very high mortality rate in Korea. This disease is known to have various reasons, including infection with Helicobacter pylori, dietary habits, tobacco, and a...
Gastritis is a major disease that has the potential to grow as gastric cancer. Gastric cancer is a very common cancer, and it is related to a very high mortality rate in Korea. This disease is known to have various reasons, including infection with Helicobacter pylori, dietary habits, tobacco, and alcohol. The incidence rate of gastritis has reported to differ between age, population, and gender. However, unlike other factors, there has been no analysis based on gender. So, we examined the high risk factors of gastritis in each gender in the Korean population by focusing on sex. We performed an analysis of 120 clinical characteristics and genome-wide association studies (GWAS) using 349,184 single-nucleotide polymorphisms from the results of Anseong and Ansan cohort study in the Korea Association Resource (KARE) project. As the result, we could not prove a strong relation with these factors and gastritis or gastric ulcer in the GWAS. However, we confirmed several already-known risk factors and also found some differences of clinical characteristics in each gender using logistic regression. As a result of the logistic regression, a relation with hyperlipidemia, coronary artery disease, myocardial infarction, hyperlipidemia therapy, hypotensive or antihypotensive drug, diastolic blood pressure, and gastritis was seen in males; the results of this study suggest that vascular disease has a potential association with gastritis in males.
Gastritis is a major disease that has the potential to grow as gastric cancer. Gastric cancer is a very common cancer, and it is related to a very high mortality rate in Korea. This disease is known to have various reasons, including infection with Helicobacter pylori, dietary habits, tobacco, and alcohol. The incidence rate of gastritis has reported to differ between age, population, and gender. However, unlike other factors, there has been no analysis based on gender. So, we examined the high risk factors of gastritis in each gender in the Korean population by focusing on sex. We performed an analysis of 120 clinical characteristics and genome-wide association studies (GWAS) using 349,184 single-nucleotide polymorphisms from the results of Anseong and Ansan cohort study in the Korea Association Resource (KARE) project. As the result, we could not prove a strong relation with these factors and gastritis or gastric ulcer in the GWAS. However, we confirmed several already-known risk factors and also found some differences of clinical characteristics in each gender using logistic regression. As a result of the logistic regression, a relation with hyperlipidemia, coronary artery disease, myocardial infarction, hyperlipidemia therapy, hypotensive or antihypotensive drug, diastolic blood pressure, and gastritis was seen in males; the results of this study suggest that vascular disease has a potential association with gastritis in males.
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대상 데이터
There were 1,885 patients and 6,957 normal subjects. First, for selecting the case, we eliminated 104 patients who were diagnosed under age 20 or had unknown age. Then, 1,781 patients remained.
Of these, 804 patients were men, and 977 patients were women. Of 6,957 normal subjects, no one was aged under 20; 3,335 were men, and 3,622 were women.
Then, 1,781 patients remained. Of these, 804 patients were men, and 977 patients were women. Of 6,957 normal subjects, no one was aged under 20; 3,335 were men, and 3,622 were women.
Detailed information of the KARE data was reported [10]. The KARE data included 8,842 individuals, 352,228 SNPs, and 277 phenotypes.
Among 8,842 total individuals, we divided patients and normal subjects for a control and case study using a positive diagnosis experience of gastritis. There were 1,885 patients and 6,957 normal subjects. First, for selecting the case, we eliminated 104 patients who were diagnosed under age 20 or had unknown age.
데이터처리
We also assessed the result factors of the logistic regression by Student’s t-test for revealing meaningful differences between patients and normal subjects using R version 3.0.2 for finding gastritis-associated factors.
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