[논문]Oral Administration of SSC201, a Medicinal Herbal Formula, Suppresses Atopic Dermatitis-Like Skin Lesions

Park, Bo-Kyung; Park, Yang-Chun; Jung, In Chul; Kim, Seung-Hyung; Choi, Jung-Eun; Park, Sunyoung; Choi, Jeong June; Jin, Mirim

doi:10.1089/jmf.2013.2941

[해외논문] Oral Administration of SSC201, a Medicinal Herbal Formula, Suppresses Atopic Dermatitis-Like Skin Lesions

Journal of medicinal food, v.17 no.4, 2014년, pp.496 - 504

Park, Bo-Kyung (Laboratory of Pathology, College of Oriental Medicine, Oriental Hospital of Daejeon University) , Park, Yang-Chun (Department of Internal Medicine, Oriental Hospital of Daejeon University) , Jung, In Chul (Department of Neuropsychiatry, Oriental Hospital of Daejeon University) , Kim, Seung-Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University) , Choi, Jung-Eun (Laboratory of Pathology, College of Oriental Medicine, Oriental Hospital of Daejeon University) , Park, Sunyoung (Laboratory of Pathology, College of Oriental Medicine, Oriental Hospital of Daejeon University) , Choi, Jeong June (Natural Products Research Institute, Gyeonggi Institute of Science and Technology Promotion) , Jin, Mirim (Laboratory of Pathology, College of Oriental Medicine, Oriental Hospital of Daejeon University)

Abstract ▼ AI-Helper

Atopic dermatitis (AD) is a chronic inflammatory skin disease, which requires safe and effective treatment. In this study, we evaluated the effects of SSC201, a herbal formulation consisting of Stemonae Radix, Spirodelae Herba, and Cnidii Fructus, on the development of AD induced by 2,4-dinitrochlorobenzene in the NC/Nga murine model. Oral administration of SSC201 significantly reduced the severity of dermatitis and the tendency of mice to scratch their lesions. SSC201 significantly reduced the thickening of the epidermis/dermis and the infiltration of T cells, eosinophils, and mast cells into the dermis. These results were supported by findings of reduced numbers of $CD4^+$, $CCR3^+$, and $CD117^+Fc{\varepsilon}RI{\alpha}^+$ cells in the skin. Furthermore, SSC201 significantly decreased the number of $CD4^+$, $CD8^+$, and $CD3^+CD69^+$ T cells in lymph nodes. SSC201 not only decreased the plasma levels of immunoglobulin E (IgE) and the numbers of IgE-producing B cells ($B220^+CD23^+$), but also reduced the number of eosinophils and the levels of eotaxin as well as concentrations of thymus and activation-regulated chemokine in the periphery. Splenic levels of Th2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, were reduced, whereas the levels of IL-12, a Th1 cytokine, were increased. Taken together, our data suggest that SSC201 may be an effective therapeutic agent for the treatment of AD.

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[해외논문] Oral Administration of SSC201, a Medicinal Herbal Formula, Suppresses Atopic Dermatitis-Like Skin Lesions

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[해외논문] Oral Administration of SSC201, a Medicinal Herbal Formula, Suppresses Atopic Dermatitis-Like Skin Lesions

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