최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기韓國資源植物學會誌 = Korean journal of plant resources, v.27 no.1, 2014년, pp.22 - 28
In this study, we conducted the anti-HIV-1 enzymes assay in vitro and its active components were predicted by QSAR in silico for the elucidation of action mechanism on anti-HIV of natural resources. The extracts of Gardenia jasminoides var. radicans Makino were tested for their inhibitory effects on...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
꽃치자나무 추출물의 ELOSA 방법으로 실험한 역전사효소 억제활성실험은 어떠한 결과는 나타냈는가? | 꽃치자나무 추출물의 HIV-1 reverse transcriptase, protease 및 alpha-glucosidase에 대한 억제활성실험을 실시하였다. ELOSA 방법으로 실험한 역전사효소 억제활성 실험에서는 꽃치자나무 잎 MeOH 추출물 $100{\mu}g/ml$ 농도에서 13.4%의 약한 억제활성이 관찰되었고, 줄기의 메탄올추출물에서는 32.5%의 높은 HIV-1 protease 억제활성과 줄기의 메탄올 추출물에서는 26.1%의 alpha-glucosidase 억제활성이 관찰되었다. 그리고 HIV-1 복제 억제활성은 MT-4 세포에 대한 HIV-1 유도 세포변성억제를 광학현미경으로 관찰하여 살펴본 결과 잎과 줄기의 모든 추출물에서 HIV-1 바이러스 증식억제에 억제활성이 관찰되지 않았다. | |
치자란 무엇인가? | 치자(梔子)는 꽃치자나무(Gardenia jasminoides var. radicans Makino)와 치자나무(Gardenia jasminoides Ellis)의 열매로서, 꽃치자나무는 주로 우리나라 남부지방에 재배하거나 자생한다(Moon et al., 2002). | |
치자, 치자 잎, 꽃의 화학성분으로는 어떤 것들이 있는가? | 치자와 치자 잎의 화학성분으로는 genipin, geniposide, gardenoside와 shanzhiside 등 iridoid 계열의 성분들이 밝혀져 있으며, 꽃에서는 crocin, crocetin 등 황색 색소 성분이 보고되어 있다(Moon et al., 2002). |
Balzarini, J., J. Neyts., D. Schols., M. Hosoya., E. Van Damme., W. Peumans and E. De clercq. 1992. The mannose-specific plants lectins from Cymvidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro. Antiviral Res. 18:191-207.
Batinic, D. and R.A. Robey. 1992. The V3 region of the envelope glycoprotein of human immunodeficiency virus type 1 binds sulfated polysaccharides and CD4-derived synthetic peptides. J. Bio. Chem. 267:6664-6671.
Deng, Y., M. Guan, X. Xie, X. Yang, H. Xiang , H. Li, L. Zou, J. Wei, D. Wang and X. Deng. 2013. Geniposide inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. Int Immunopharmacol. 17(3):561-567.
Guan, L., H. Feng, D. Gong, X. Zhao, L. Cai, Q. Wu, B. Yuan, M. Yang, J. Zhao and Y. Zou. 2013. Genipin ameliorates age-related insulin resistance through inhibiting hepatic oxidative stress and mitochondrial dysfunction. Exp Gerontol. 48(12):1387-94.
Han, C.H. and Y.B. Yu. 2006. Inhibitory effects of Ricinus communis on HIV-1 essential enzymes in vitro and Prediction of inhibitory factro using QSAR in silico. Korean J. Oriental Int. Med. 27(4):888-894 (in Korean).
Hong, Y.J. and K.S. Yang. 2013. Anti-inflammatory activities of crocetin derivatives from processed Gardenia jasminoides. Arch Pharm Res. 36(8):933-940.
Kakiuchi, N., M. Hattori and T. Namba. 1985. Inhibitory effect of tannins on reverse transcriptase from RNA tumor virus. J. Nat. Prod. 48(4):614-621.
Kaminchik, J., R. Margalit., S. Yaish., H. Drummer., B. Amit., N. Saver., M. Gorecki and A. Panet. 1994. Cellular distribution of HIV type I nef protein: Identification of domains in nef required for association with membrane and detergent-insoluble cellular matrix. Aids Res. and Human Retrovir. 10:1003-1010.
Katz, R.A. and A.M. Skalka. 1994. The retroviral enzymes. Annu. Rev. Biochem. 63:133-173.
Kusumoto, I.T., M. Hattori, Y. Miyaichi, T. Tomimori, M. Hanaoka and T. Namba. 1991. Effects of flavonoids and alkaloids on reverse transcriptase. Shoyakugaku Zasshi 45: 240-254.
Kusumoto, I.T., T. Nakabayashi., H. Kida., H. Miyashiro., M. Hattori., T. Namba and K. Shimotohno. 1995. Screening of various plant extracts used in ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1 (HIV-1) protease. Phytotherpy Res. 9:180-184.
Li, H.B., Y. Yu, Z.Z. Wang, Y. Dai, H. Gao, W. Xiao and X.S. Yao. 2013. Iridoid and bis-iridoid glucosides from the fruit of Gardenia jasminoides. Fitoterapia 88C:7-11.
Mayaux, J.F., A. Bousseau., R. Pauwels., T. Huet., Y. Henin., N. Dereu., M. Evers., F. Soler., C. Poujade., E. De Clercq and J.B. Le Pecq. 1994. Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells. Proc. Natl. Acad. Sci. 91:3564-3568.
Mohan, P. 1992. Anti-AIDS drug development: challenges and strategies. Pharmaceutical Res. 9(6):703-714.
Moon, H.I., J.S. Oh, J.S. Kim, P.C. Chen and O.P. Zee. 2002. Phytochemical Compounds from the underground parts of Gardenia jasminoides var. radicans Makino. Kor. J. Pharmacogn. 33(1):1-4 (in Korean).
Nakashima, H., T. Murakami., N. Yamamoto., H. Sakagami., S. Tanuma., T. Hatano., T. Yoshida and T. Okuda. 1992. Inhibition of human immunodeficiency viral replication by tannins and related compounds. Antiviral Res. 18:91-103.
Otake, T., H. Mori., M. Morimoto., N. Ueba and I..T. Kusumoto. 1994. Anti-human immunodeficiency virus activity of some tropical medicinal plants. J. Traditional Med. 11:188-193.
Peliska, J.A. and S. J. Benkovic. 1992. Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. Science 258:1112-1118.
Prasad, V.R. and S.P. Goff. 1989. Linker insertion mutagenesis of human immunodeficiency virus reverse transcriptase expressed in bacteria: definition of the minimal polymerase domain. Proc. Natl. Acad. Sci. 86:3104-3108.
Rossmann, M.G. 1988. Antiviral agents targeted to interact with viral capsid proteins and a possible application to human immunodeficiency virus. Proc. Natl. Acad. Sci. 85:4625-4627.
Shin, Y.W., D.H. Kim. and N.J. Kim. 2003. Studies on the processing of crude drugs (VII)-On the constituents and biological activities of Gardeniae Fructus by processing. Kor. J. Pharmacogn. 34(1):45-54 (in Korean).
Taraporewala, I.B., J.W. Cessac., T.C. Chanh., A.V. Delgado and R.F. Schinazi. 1992. HIV-1 neutralization and tumor cell proliferation inhibition in vitro by simplified analogues of pyrido[4,3,2-mn]thiazolo[5,4-b]acridine marine alkaloids. J. Med. Chem. 35(15):2744-2752.
Taylor, D.L., M.S. Kang., T.M. Brennan., C.G. Bridges., P.S. Sunkara and A.S. Tyms. 1994. Inhibition of $\alpha$ -glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoyl castanospermine (MDL 28,574) and its consequences in human immunodeficiency virus-infected T cells. Antimicrobacterial Agents and Chemother. 38(8):1780-1787.
Weber, P.C., D.H. Ohlendorf., J.J. Wendoloski and F.R. alemme. 1989. Structural origins of high-affinity biotin binding to streptavidin. Science 243:85-88.
Yang, S.S., G.M. Cragg., D.J. Newman and J.P. Bader. 2001. Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program. J. Nat. Prod. 64(2):265-277.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.