최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, v.18 no.2, 2014년, pp.155 - 161
Yu, Un Young (Department of Biochemistry, Ewha Womans University College of Medicine) , Yoo, Byong Chul (Colorectal Cancer Branch, Research Institute, National Cancer Center) , Ahn, Jung-Hyuck (Department of Biochemistry, Ewha Womans University College of Medicine)
Overexpression of amyloid precursor protein with the Swedish mutation causes abnormal hyperphosphorylation of the microtubule-associated protein tau. Hyperphosphorylated isoforms of tau are major components of neurofibrillary tangles, which are histopathological hallmarks of Alzheimer's disease. Pro...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
1 Alonso AC Grundke-Iqbal I Iqbal K Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules Nat Med 1996 2 783 787 8673924
2 Mairet-Coello G Courchet J Pieraut S Courchet V Maximov A Polleux F The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation Neuron 2013 78 94 108 23583109
3 Louis JV Martens E Borghgraef P Lambrecht C Sents W Longin S Zwaenepoel K Pijnenborg R Landrieu I Lippens G Ledermann B Götz J Van Leuven F Goris J Janssens V Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta Proc Natl Acad Sci U S A 2011 108 6957 6962 21482799
4 Liu Y Su Y Sun S Wang T Qiao X Run X Liang Z Tau phosphorylation and µ-calpain activation mediate the dexamethasone-induced inhibition on the insulin-stimulated Akt phosphorylation PLoS One 2012 7 e35783 22536436
5 Choe MA Koo BS An GJ Jeon S Effects of treadmill exercise on the recovery of dopaminergic neuron loss and muscle atrophy in the 6-ohda lesioned parkinson's disease rat model Korean J Physiol Pharmacol 2012 16 305 312 23129977
6 Mercado-Gómez O Hernández-Fonseca K Villavicencio-Queijeiro A Massieu L Chimal-Monroy J Arias C Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation Neurochem Res 2008 33 1599 1609 18461448
7 Kuo YC Huang KY Yang CH Yang YS Lee WY Chiang CW Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt J Biol Chem 2008 283 1882 1892 18042541
8 Qian W Shi J Yin X Iqbal K Grundke-Iqbal I Gong CX Liu F PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta J Alzheimers Dis 2010 19 1221 1229 20308788
9 Zhang H Sun S Herreman A De Strooper B Bezprozvanny I Role of presenilins in neuronal calcium homeostasis J Neurosci 2010 30 8566 8580 20573903
10 Ahn JH Sung JY McAvoy T Nishi A Janssens V Goris J Greengard P Nairn AC The B"PR72 subunit mediates Ca 2+ -dependent dephosphorylation of DARPP-32 by protein phosphatase 2A Proc Natl Acad Sci U S A 2007 104 9876 9881 17535922
11 Ahn JH McAvoy T Rakhilin SV Nishi A Greengard P Nairn AC Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit Proc Natl Acad Sci U S A 2007 104 2979 2984 17301223
12 Margolis SS Perry JA Forester CM Nutt LK Guo Y Jardim MJ Thomenius MJ Freel CD Darbandi R Ahn JH Arroyo JD Wang XF Shenolikar S Nairn AC Dunphy WG Hahn WC Virshup DM Kornbluth S Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis Cell 2006 127 759 773 17110335
14 Sontag JM Nunbhakdi-Craig V White CL 3rd Halpain S Sontag E The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies J Biol Chem 2012 287 14984 14993 22403409
15 Salcedo-Tello P Hernández-Ortega K Arias C Susceptibility to GSK3β-induced tau phosphorylation differs between the young and aged hippocampus after wnt signaling inhibition J Alzheimers Dis 2014 39 775 785 24270208
17 Park JH Sung HY Lee JY Kim HJ Ahn JH Jo I B56α subunit of protein phosphatase 2A mediates retinoic acid-induced decreases in phosphorylation of endothelial nitric oxide synthase at serine 1179 and nitric oxide production in bovine aortic endothelial cells Biochem Biophys Res Commun 2013 430 476 481 23237802
18 Wang JZ Xia YY Grundke-Iqbal I Iqbal K Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration J Alzheimers Dis 2013 33 Suppl 1 S123 S139 22710920
19 Kamat PK Rai S Swarnkar S Shukla R Ali S Najmi AK Nath C Okadaic acid-induced Tau phosphorylation in rat brain: role of NMDA receptor Neuroscience 2013 238 97 113 23415789
20 Janssens V Longin S Goris J PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail) Trends Biochem Sci 2008 33 113 121 18291659
21 Li X Virshup DM Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A Eur J Biochem 2002 269 546 552 11856313
22 Ahn JH Kim Y Kim HS Greengard P Nairn AC Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A PLoS One 2011 6 e26292 22046270
23 Creyghton MP Roël G Eichhorn PJ Hijmans EM Maurer I Destrée O Bernards R PR72, a novel regulator of Wnt signaling required for Naked cuticle function Genes Dev 2005 19 376 386 15687260
24 Cho US Xu W Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme Nature 2007 445 53 57 17086192
25 Longin S Zwaenepoel K Louis JV Dilworth S Goris J Janssens V Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit J Biol Chem 2007 282 26971 26980 17635907
26 Arif M Kazim SF Grundke-Iqbal I Garruto RM Iqbal K Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam Proc Natl Acad Sci U S A 2014 111 1144 1149 24395787
27 Sontag JM Nunbhakdi-Craig V Montgomery L Arning E Bottiglieri T Sontag E Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation J Neurosci 2008 28 11477 11487 18987184
28 Landrieu I Smet-Nocca C Amniai L Louis JV Wieruszeski JM Goris J Janssens V Lippens G Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau PLoS One 2011 6 e21521 21731772
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.