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NTIS 바로가기大韓韓醫學方劑學會誌 = Herbal formula science, v.22 no.1, 2014년, pp.151 - 165
이경선 (원광대학교 약학대학 한약학과 방제학교실) , 최은식 (원광대학교 약학대학 한약학과 방제학교실) , 한상용 (원광대학교 약학대학 한약학과 방제학교실) , 김윤경 (원광대학교 약학대학 한약학과 방제학교실)
Objectives : The aim of this study was to evaluate the efficacy of Aconiti Lateralis Preparata Radix (AP) and Acanthopanacis Cortex (AT) extracts in bone-derived adipocyte OP9 cell, osteoclast and osteoblast-like MG63 cells. Methods : MTT assay was used to evaluate the cytotoxicity of AP and AT extr...
핵심어 | 질문 | 논문에서 추출한 답변 |
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비만이란 무엇인가 ? | 비만이란 열량의 섭취와 소비의 불균형으로 나타나는 대사성 질환으로 신체활동의 감소 및 과도한 칼로리 섭취로 인해 비만 인구는 급속도로 증가하고 있다1,2). 비만은 단순히 체중 증가현상만을 의미하는 것이 아니라 고혈압, 고지혈증, 제2형 당뇨병 등과 같은 대사성 질환들과 밀접한 연관되어 이러한 질병들의 발병률을 증가시킨다고 보고된 바 있다. | |
골아세포와 지방세포의 공통점은 ? | 골아세포와 지방세포는 중배엽줄기계의 세포로서 분화할 수 있는 능력을 가진 미분화세포인 인간 골수 유래 간엽세포로부터 분화되었다는 공통점을 갖는다9). 골 질환이 비정상적인 파골세포의 분화와 관련된 것처럼 비만과 관련해 지방세포의 분화가 지방축적에 가장 결정적인 역할을 한다고 알려져 있다. | |
골다공증유병률이 50대 이상의 여자에게 높은 이유는 ? | 이 결과로 골다공증과 비만의 유병률이 50대 이상의 여자에게서 높게 나타나므로 여성노인의 건강문제에 대한 관심이 높아지고 있다. 이는 폐경 후 에스트로겐의 골 대사, 지질대사 및 혈관 보호효과가 약화되면서 비만, 골다공증 및 심혈관계질환의 발생률이 높아지는 것으로 파악된다. 폐경기이후 체중 증가의 기전은 폐경후 신체에 콜레스테롤이 에스트로겐으로의 전환율이 감소하면서 혈중 콜레스테롤 수치가 상승하고, 지방조직의 증가는 내장 지방량을 증가시켜 복부비만이 많아지게 된다33)고 알려져 있다. |
Kopelman PG. Obesity as a medical problem. Nature. 2000; 404(6778): 635-643.
Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001; 104: 531-543.
Parfitt AM. Bone remodeling: Relationship to the amount and structure of bone the pathogenesis and prevention of fractures. In; Osteoporosis, Etiology, Diagnosis and Management. Melton L,J(ed). New York: Reven Press. 1988; 45-93.
Stein GS, Lian JB, Wijnen AJ, Montechino M. Transcriptional control of osteoblast growth and differentiation. Physiol. 1996; 76: 593-629.
Rodan GA, Marti TJ. Therapeutic approaches to bone diseases. Science. 2000; 289(5484): 1508-1541.
Okamoto K, Takayanagi H. Regulation of bone by the adaptive immune system in arthritis. Arthritis Res Ther. 2011; 13(3):219. Review.
Qiao C, Xu W, Zhu W, et al. Human mesenchymal stem cells isolated from the umbilical cord. Cell Biol int. 2008; 32: 8-15.
Darlington GJ, Rose SE, MacDougald OA. The role of C/EBP genes in adipocyte differentiation. J Biol Chem. 1998; 273: 30057-30060.
Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM. $C/EBP{\alpha}$ induses adipogenesis through $PPAR{\gamma}$ : A unified pathway. Genes Dev. 2002; 16: 22-26.
Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. Mol Cell Endocrinol. 2010; 316: 129-139.
Alessi MC, Lijnen HR, Bastelica D, Juhan-Vague I. Adipose tissue and atherothrombosis. Pathophysiol Haemost Thromb. 2003; 33: 290-297.
Masse PG, Tranchant CC, Dosy J, Donovan SM. Coexistence of osteoporosis and cardiovascular disease risk factors in apparently healthy, untreated postmenopausal women. Int J Vitam Nutr Res. 2005; 75(2): 97-106.
Apfellbaum M, Vague, P, Ziegler O, IIanotin O, Thomas F, Leu-tenegger E. Long-term maintenance of weight loss after a very low calorie diet; Efficacy and tolerabillity of sibutramine. Am J Med. 1999; 106: 179-184.
Pole HAP, Felsenberg D, Hanley DA, Stenpan J, Munoz-Torres M, Wolkins TJ, Qui-Sheng G, Galich M, Vandormael K, Yates AJ. Multinational placebo-controlled, randomised trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with law bone mass: Results of the FOSIT. Osteoporosis Int. 1999; 9: 461-468.
Chu J. Bon-Kyung-So-Jeung. Seoul: Daeseong medical publishers, 2001: 565-566.
S Nishibe, H Kinoshita, H Takeda, G Okano. Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats. Chem Pharm Bull. 1990; 38(6): 1763-1765.
T Fujikawa, A Yamaguchi, I Morita, H Takeda, S Nishibe. Protective effects of Acanthopanax senticosus Harms from Hokkaido and its components on gastric ulcer in restrained cold water stressed rats. Biol Pharm Bull. 1996; 19(9): 1227-1230.
Lee GM, Kim KS, Jang JD, Kim KY. Study of Aconiti tuber on normal Rats : change of body weight, transaminase. The journal of Korean Acupuncture & Moxibustion Society. 1999; 16(1): 269-282.
Professors of Herbology, College of Oriental Medicine. Herbal medicine. Seoul: Yeongnim publishers, 1999: 283-284.
Lee SM. Inhibitory effects of acanthopanacis cortex on the osteoclast formation. Dept. of Herbal Medicine. Semyung University Graduate School. 2007.
Im SY, Im JY, Lee CS, Jang YJ, Park JY, Yun S. Antioxidant and cell proliferation effects of Acanthopanax senticosus for extract in human osteoblast-like MG-63 cell line. Korean J FOOD SCI. TECHNOL. 2007; 39(6): 694-700.
Yang JY, Lee KS, Kim MK, Moon SK, Kang MK, Park BH, Kim JS, Park JW. Effect of Acanthopanax senticosus on lipoprotein lipase in 3T3-L1 adipocytes. Phytother Res. 2004; 18(2):160-3.
Jeoung JH, Lee YH, Kang SG. Preventive effect on development of diabetes and renoprotective Effect of Acanthopanax Senticosus aqua-acupuncture in multiple low-dose streptozotocin-induced diabetic rats. The Acupuncture. 2003; 20(3): 1-14.
Kim HC, Lee SI, Ahn DK. Effect of Acanthopanacis Cortex on the IL-8 production in human monocyte as a rheumatoid arthritis remedy. The Korea Journal of Herbology. 1995; 10(1): 49-58.
Han DS. Pharmacognosy. Gyeonggi-do: Dongmyeong publishers, 1997: 156.
Kim JH, Choi YH, Hwang WD. Inhibition of cell proliferation and induction of apoptosis by methanolic extract of Aconiti Tuber in human renal cell carcinoma cells. The Journal of Korean Oriental Internal Medicine. 2008; 29(1): 42-66.
Jeong HS. Effects of Cinnamomum Cassia and Aconitum Carmichaeli′s phamacopunture and oral administration on blood sugar in TypeII diabetic mice. Woosuk University Graduate School, 2009: 37-39.
Lee SH, Lee BC, Ahn YM, Doo HK, Ahn SY. The Effects of Aconiti Radix on thyroid function in hypothyroidism rat model induced by 6-propyl-2-thiouracil (PTU). The Journal of Korean Oriental Internal Medicine. 2007; 28(2): 275-283.
Ministry of Health and Welfare. 2010 National Health Statistics. 2011: 52, 68.
Broussard DL, Magnus JH. Coronary heart disease risk and bone mineral density among U.S. women and men. J Womens Health. 2008; 17(3): 479-490.
Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci. 1992; 102: 341-351.
Muruganandan S, Roman AA, Sinal CJ. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell Mol Life Sci. 2009; 66: 236-253.
Im KI. Intracellular signal transduction pathways and transcription factors for osteogenesis. Korean College of Rheumatology. 2008; 15(1): 1-10.
Quan Kang, et al. A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev. 2009; 18(4): 545-558.
Jeong Hwan Kim, et al. Wnt Signaling in Bone Formation and Its Therapeutic Potential for Bone Diseases. Ther Adv Musculoskel Dis. 2013; 5(1): 13-31.
Wellman NS, Friedberg B. Causes and consequenses of adult obesity: health, social and economic impacts in the united States. Asia Pac J Clin Nutr. 2002; 11 Suppl 8: S705-S709.
Wyatt SB, Winters KP, Dubbert PM. Overweight and obesity: prevalence, consequenses, and causes of a growing public health prolem. Am J Med Sci. 2006; 331: 166-174.
Choi WH. Differentiation of adipocyte. Korean J Obes. 1999; 8(1): 3-7.
Burns RP, Kim JB, Hu E, Altiok S, Spiegelman BM. Adipocyte differentiation; a transcriptional regulatory. Curr Opin Cell Biol. 1996; 8: 826-832.
Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev. 1998; 78: 783-809.
Saitoa T, Abea D, Sekiya K. Flavanone exhibits $PPAR{\gamma}$ ligand activity and enhances differentiation of 3T3-L1 adipocytes. Biochem Bioophys Res Commun. 2009; 380: 281-285.
Tontonoz P, Hu E, Spiegelman BM. Regulation of adipocyte of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma. Curr Opin Genet Dev. 1995; 5: 571-576.
Freytang SO, Paielli DL, Gilbert JD. Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev. 1994; 8: 1654-1663.
Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev. 2000; 14: 293-307.
Ikeda F, Nishimura R, Matsubara T, Hata K, Reddy SV, Yoneda T. Activation of NFAT signal in vivo leads to osteopenia associated with increased osteoclastogenesis and bone-resorbing activity. J Immunol. 2006; 177(4): 2384-2390.
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