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Abstract ▼ AI-Helper

Recent advances in cognitive neuroscience have focused on the role of inter-areal interactions between various specialized brain regions and functional connectivity in human cognition. Decades of neuroimaging and patient lesion studies demonstrated the correlation between the roles of specific brain...

Recent advances in cognitive neuroscience have focused on the role of inter-areal interactions between various specialized brain regions and functional connectivity in human cognition. Decades of neuroimaging and patient lesion studies demonstrated the correlation between the roles of specific brain structures in memory retrieval, however, neuronal mechanisms based on effective connectivity underlying the coordination of this anatomically distributed information processing have remain largely unknown. Here we investigate the information flow network of the human brain during memory retrieval. The experimental results reveal that the episodic memory retrieval involves increase of information flow and densely interconnected networks between the prefrontal cortex, the medial temporal lobe, and some subregions of the parietal and occipital cortex. In this network, interestingly, we found the SFG acted as a hub, globally interconnected across broad brain regions.

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