다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Molecules and cells, v.37 no.6, 2014년, pp.441 - 448
Choi, Alexander J.S. (Center for Sleep Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, Tufts University School of Medicine) , Ryter, Stefan W. (Joan and Sanford I. Weill Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College)
AI-Helper
Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes. These multiprotein complexes activate inflamma...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
Alcocer-Gómez E. de Miguel M. Casas-Barquero N. Núñez-Vasco J. Sánchez-Alcazar J.A. Fernández-Rodríguez A. Cordero M.D. 2013 NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder Brain Behav. Immun. 36 111 117 24513871
Allen I.C. Scull M.A. Moore C.B. Holl E.K. McElvania-TeKippe E. Taxman D.J. Guthrie E.H. Pickles R.J. Ting J.P. 2009 The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA Immunity 30 556 565 19362020
Balistreri C.R. Colonna-Romano G. Lio D. Candore G. Caruso C. 2009 TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases J. Clin. Immunol. 29 406 415 19459036
Bauernfeind F.G. Horvath G. Stutz A. Alnemri E.S. MacDonald K. Speert D. Fernandes-Alnemri T. Wu J. Monks B.G. Fitzgerald K.A. 2009 Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression J. Immunol. 183 787 791 19570822
Chatterjee S. Rana R. Corbett J. Kadiiska M.B. Goldstein J. Mason R.P. 2012 P2X7 receptor–NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice Free Radic. Biol. Med. 52 1666 1679 22343416
Davis B.K. Wen H. Ting J.P. 2011 The Inflammasome NLRs in immunity, inflammation, and associated diseases Ann. Rev. Immun. 29 707 735 21219188
Devi T.S. Lee I. Hüttemann M. Kumar A. Nantwi K.D. Singh L.P. 2012 TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy Exp. Diabetes Res. 2012 438238 22474421
Donath M.Y. Shoelson S.E. 2011 Type 2 diabetes as an inflammatory disease Nat. Rev. Immunol. 11 98 107 21233852
Dostert C. Pétrilli V. Van Bruggen R. Steele C. Mossman B.T. Tschopp J. 2008 Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica Science 320 674 677 18403674
Dowlati Y. Herrmann N. Swardfager W. Liu H. Sham L. Reim E.K. Lanctôt K.L. 2010 A meta-analysis of cytokines in major depression Biol. Psychiatry 67 446 457 20015486
Eizirik D.L. Sammeth M Bouckenooghe T. Bottu G. Sisino G. Igoillo-Esteve M. Ortis F. Santin I. Colli M.L. Barthson J. 2012 The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines PLoS Genet 8 e1002552 22412385
Emanuela F. Grazia M. Marco de R. Maria Paola L. Giorgio F. Marco B. 2012 Inflammation as a link between obesity and metabolic syndrome J. Nutr. Metab. 2012 476380 22523672
Faustin B. Lartigue L. Bruey J.M. Luciano F. Sergienko E. Bailly-Maitre B. Volkmann N. Hanein D. Rouiller I. Reed J.C. 2007 Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell 25 713 724
Feve B. Bastard J.P. 2009 The role of interleukins in insulin resistance and type 2 diabetes mellitus Nat. Rev. Endocrinol. 5 305 311 19399017
Finucane M.M. Stevens G.A. Cowan M.J. Danaei G. Lin J.K. Paciorek C.J. Singh G.M. Gutierrez H.R. Lu Y. Bahalim A.N. 2011 National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants Lancet 337 557 567 21295846
Franchi L. Eigenbrod T. Nuñez G. 2009 Cutting edge: TNF-a mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation J. Immunol. 183 792 796 19542372
Fujihara M. Muroi M. Tanamoto K. Suzuki T. Azuma H. Ikeda H. 2003 Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex Pharmacol. Ther. 100 171 194 14609719
Glass C.K. Saijo K. Winner B. Marchetto M.C. Gage F.H. 2010 Mechanisms underlying inflammation in neurodegeneration Cell 140 918 934 20303880
Glinsky G.V. 2008 SNP-guided microRNA maps (MirMaps) of 16 common human disorders identify a clinically accessible therapy reversing transcriptional aberrations of nuclear import and inflammasome pathways Cell Cycle 7 3564 3576 19001869
Guarda G. Zenger M. Yazdi A.S. Schroder K. Ferrero I. Menu P. Tardivel A. Mattmann C. Tschopp J. 2011 Differential expression of NLRP3 among hematopoietic cells J. Immunol. 186 2529 2534 21257968
Halle A. Hornung V. Petzold G.C. Stewart C.R. Monks B.G. Reinheckel T. Fitzgerald K.A. Latz E. Moore K.J. Golenbock D.T. 2008 The NALP3 inflammasome is involved in the innate immune response to amyloid-beta Nat. Immunol. 9 857 865 18604209
Heid M.E. Keyel P.A. Kamga C. Shiva S. Watkins S.C. Salter R.D. 2013 Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation J. Immunol. 191 5230 5238 24089192
Heneka M.T. Kummer M.P. Stutz A. Delekate A. Schwartz S. Vieira-Saecker A. Griep A. Axt D. Remus A. Tzeng TC. 2013 NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice Nature 493 674 678 23254930
Hentze H. Lin X.Y. Choi M.S. Porter A.G. 2003 Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin Cell Death Differ. 10 956 968 12934070
Hiscott J. Marois J. Garoufalis J. D’Addario M. Roulston A. Kwan I. Pepin N. Lacoste J. Nguyen H. Bensi G. 1993 Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive auto-regulatory loop Mol. Cell. Biol. 13 6231 6240 8413223
Hook V.Y. Kindy M. Hook G. 2008 Inhibitors of cathepsin B Improve memory and reduce b-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, b-secretase site of the amyloid precursor protein J. Biol. Chem. 283 7745 7753 18184658
Hornung V. Bauernfeind F. Halle A. Samstad E.O. Kono H. Rock K.L. Fitzgerald K.A. Latz E. 2008 Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nat. Immunol. 9 847 856 18604214
Hornung V. Ablasser A. Charrel-Dennis M. Bauernfeind F. Horvath G. Caffrey D.R. Latz E. Fitzgerald K.A. 2009 AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC Nature 458 514 518 19158675
Itagaki S. McGeer P.L. Akiyama H. Zhu S. Selkoe D. 1989 Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease J. Neuroimmunol. 24 173 182 2808689
Iwata M. Ota K.T. Duman R.S. 2013 The inflammasome: pathways linking psychological stress, depression, and systemic illnesses Brain Behav. Immun. 31 105 114 23261775
Jankowsky J.L. Slunt H.H. Ratovitski T. Jenkins N.A. Copeland N.G. Borchelt D.R. 2001 Co-expression of multiple transgenes in mouse CNS: a comparison of strategies Biomol. Eng. 17 157 165 11337275
Kahn S.E. Hull R.L. Utzschneider K.M. 2006 Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 840 846 17167471
Kanneganti T.D. Lamkanfi M. Kim Y.G. Chen G. Park J.H. Franchi L. Vandenabeele P. Núñez G. 2007 Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling Immunity 26 433 443 17433728
Kessler R.C. Berglund P. Demler O. Jin R. Koretz D. Merikangas K.R. Rush A.J. Walters E.E. Wang P.S. National Comorbidity Survey Replication 2003 The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) J. Am. Med. Assoc. 289 3095 3105
Koo J.W. Duman R.S. 2008 IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress Proc. Natl. Acad. Sci. USA 105 751 756 18178625
Korcok J. Raimundo L.N. Ke H.Z. Sims S.M. Dixon S.J. 2004 Extracellular nucleotides act through P2X7 receptors to activate NF-kB in osteoclasts J. Bone Miner. Res. 19 642 651 15005852
Kotas M.E. Jurczak M.J. Annicelli C. Gillum M.P. Cline G.W. Shulman G.I. Medzhitov R. 2013 Role of caspase-1 in regulation of triglyceride metabolism Proc. Natl. Acad. Sci. USA 110 4810 4815 23487794
Lamkanfi M. Mueller J.L. Vitari A.C. Misaghi S. Fedorova A. Deshayes K. Lee W.P. Hoffman H.M. Dixit V.M. 2009 Glyburide inhibits the Cryopyrin/Nalp3 inflammasome J. Cell Biol. 187 61 70 19805629
Latz E. Xiao T.S. Stutz A. 2013 Activation and regulation of the inflammasomes Nat. Rev. Immunol. 13 397 411 23702978
Leemans J.C. Cassel S.L. Sutterwala F.S. 2011 Sensing damage by the NLRP3 inflammasome Immunol. Rev. 243 152 162 21884174
Liu Y. Xiao Y. Li Z. 2011 P2X7 receptor positively regulates MyD88-dependent NF-kB activation Cytokine 55 229 236 21621419
Lu M. Sun X.L. Qiao C. Liu Y. Ding J.H. Hu G. 2014 Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation. Neurobiol Aging 35 421 430
Ludlow L.E. Johnstone R.W. Clarke C.J. 2005 The HIN-200 family: more than interferon-inducible genes? Exp. Cell Res. 308 1 17 15896773
Maes M. Bosmans E. Meltzer H.Y. Scharpé S. Suy E. 1993 Interleukin-1 beta: a putative mediator of HPA axis hyper-activity in major depression? Am. J. Psychiatry 150 1189 1193 8328562
Mandrup-Poulsen T. Pickersgill L. Donath M.Y. 2010 Blockade of interleukin 1 in type 1 diabetes mellitus Nat. Rev. Endocrinol. 6 158 166 20173777
Mariathasan S. Newton K. Monack D.M. Vucic D. French D.M. Lee W.P. Roose-Girma M. Erickson S. Dixit V.M. 2004 Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf Nature 430 213 218 15190255
Martinon F. Burns K. Tschopp J. 2002 The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-1β Mol. Cell 10 417 426 12191486
Martinon F. Pétrilli V. Mayor A. Tardivel A. Tschopp J. 2006 Gout-associated uric acid crystals activate the NALP3 inflammasome Nature 440 237 241 16407889
Martinon F. Mayor A. Tschopp J. 2009 The inflammasomes: guardians of the body Annu. Rev. Immunol. 27 229 265 19302040
Masters S.L. Dunne A. Subramanian S.L. Hull R.L. Tannahill G.M. Sharp F.A. Becker C. Franchi L. Yoshihara E. Chen Z. 2010 Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1b in type 2 diabetes Nat. Immunol. 11 897 904 20835230
McGeer P.L. Itagaki S. Tago H. McGeer E.G. 1987 Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLADR Neurosci. Lett. 79 195 200 3670729
Menu P. Vince J.E. 2011 The NLRP3 inflammasome in health and disease: the good, the bad and the ugly Clin. Exp. Immunol. 166 1 15 21762124
Meyer-Luehmann M. Spires-Jones T.L. Prada C. Garcia-Alloza M. de Calignon A. Rozkalne A. Koenigsknecht-Talboo J. Holtzman D.M. Bacskai B.J. Hyman B.T. 2008 Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer’s disease Nature 451 720 724 18256671
Mraz M. Lacinova Z. Drapalova J. Haluzikova D. Horinek A. Matoulek M. Trachta P. Kavalkova P. Svacina S. Haluzik M. 2011 The effect of verylow- calorie diet on mRNA expression of inflammation-related genes in subcutaneous adipose tissue and peripheral monocytes of obese patients with type 2 diabetes mellitus J. Clin. Endocrinol. Metab. 96 E606 613 21289263
Nakahira K. Haspel J.A. Rathinam V.A. Lee S.J. Dolinay T. Lam H.C. Englert J.A. Rabinovitch M. Cernadas M. Kim H.P. 2011 Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome Nat. Immunol. 12 222 230 21151103
Parvathenani L.K. Tertyshnikova S. Greco C.R. Roberts S.B. Robertson B. Posmantur R. 2003 P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer’s disease J. Biol. Chem. 278 13309 13317 12551918
Pelegrin P. Surprenant A. 2006 Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor EMBO J. 25 5071 5082 17036048
Pelegrin P. Surprenant A. 2007 Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptakeindependent pathway J. Biol. Chem. 282 2386 2394 17121814
Pétrilli V. Papin S. Dostert C. Mayor A. Martinon F. Tschopp J. 2007 Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration Cell Death Differ. 14 1583 1689 17599094
Poyet J.L. Srinivasula S.M. Tnani M. Razmara M. Fernandes-Alnemri T. Alnemri E.S. 2001 Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1 J. Biol. Chem. 276 28309 28313 11390368
Qu Y. Misaghi S. Newton K. Gilmour L.L. Louie S. Cupp J.E. Dubyak G.R. Hackos D. Dixit V.M. 2006 Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation J. Immunol. 186 6553 6561 21508259
Qu Y. Misaghi S. Newton K. Gilmour L.L. Louie S. Cupp J.E. Dubyak G.R. Hackos D. Dixit V.M. 2011 Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation J. Immunol. 186 6553 6561 21508259
Raison C.L. Miller A.H. 2013 Malaise, melancholia and madness: The evolutionary legacy of an inflammatory bias Brain Behav. Immun. 13 467 475
Saijo K. Winner B. Carson C.T. Collier J.G. Boyer L. Rosenfeld M.G. Gage F.H. Glass C.K. 2009 A Nurr1/CoR EST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death Cell 137 47 59 19345186
Sautin Y.Y. Nakagawa T. Zharikov S. Johnson R.J. 2007 Adverse effects of the classical antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress Am. J. Physiol. Cell Physiol. 293 C584 C596 17428837
Schroder K. Tschopp J. 2010 The inflammasomes Cell 140 821 832 20303873
Schroder K. Zhou R. Tschopp J. 2010 The NLRP3 inflammasome: a sensor for metabolic danger? Science 327 296 300 20075245
Scott P. Ma H. Viriyakosol S. Terkeltaub R. Liu-Bryan R. 2006 Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals J. Immunol. 177 6370 6378 17056568
Shoelson S.E. Lee J. Goldfine A.B. 2006 Inflammation and insulin resistance J. Clin. Invest. 116 1793 1801 16823477
Skeldon A.M. Faraj M. Saleh M. 2014 Caspases and inflammasomes in metabolic inflammation Immunol. Cell Biol. 92 304 313 24518981
Solini A. Menini S. Rossi C. Ricci C. Santini E. Blasetti Fantauzzi C. Iacobini C. Pugliese G. 2013 The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation J. Pathol. 231 342 353 23843215
Stienestra R. Joosten L.A. Koenen T. van Tits B. van Diepen J.A. van den Berg S.A. Rensen P.C. Voshol P.J. Fantuzzi G. Hijmans A. 2010 The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity Metabolism 12 593 605
Stienestra R. van Diepen J.A. Tack C.J. Zaki M.H. van de Veerdonk F.L. Perera D. Neale G.A. Hooiveld G.J. Hijmans A. Vroegrijk I. 2011 Inflammasome is a central player in the induction of obesity and insulin resistance Proc. Natl. Acad. Sci. USA 108 15324 15329 21876127
Sun S. Xia S. Ji Y. Kersten S. Qi L. 2012 The ATP-P2 × 7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue Diabetes 61 1471 1478 22415881
Trnka J. Blaikie F.H. Logan A. Smith R.A. Murphy M.P. 2009 Antioxidant properties of MitoTEMPOL and its hydroxylamine Free Radic Res. 43 4 12 19058062
Vandanmagsar B. Youm Y.H. Ravussin A. Galgani J.E. Stadler K. Mynatt R.L. Ravussin E. Stephens J.M. Dixit V.D. 2011 The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance Nat. Med. 17 179 188 21217695
van Diepen J.A. Stienstra R. Vroegrijk I.O. van den Berg S.A. Salvatori D. Hooiveld G.J. Kersten S. Tack C.J. Netea M.G. Smit J.W. 2013 Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion J. Lipid Res. 54 448 456 23160218
Wang H. Capell W. Yoon J.H. Faubel S. Eckel R.H. 2014a Obesity development in caspase-1-deficient mice Int. J. Obes. (Lond) 38 152 155 23689355
Wang L. Zhai Y.Q. Xu L.L. Qiao C. Sun X.L. Ding J.H. Lu M. Hu G. 2014b Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice Exp. Neurol. 251 22 29 24220636
Warner-Schmidt J.L. Vanover K.E. Chen E.Y. Marshall J.J. Greengard P. 2011 Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans Proc. Natl. Acad. Sci. USA 108 9262 9267 21518864
Wellen K.E. Hotamisligil G.S. 2005 Inflammation, stress, and diabetes J. Clin. Invest. 115 1111 1119 15864338
Wen H. Gris D. Lei Y. Jha S. Zhang L. Huang M.T. Brickey W.J. Ting J.P. 2011 Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling Nat. Immunol. 12 408 415 21478880
World Health Organization 2002 The world health report 2002: Reducing risks, promoting healthy life Geneva WHO 1 167
World Health Organization 2011 Global status report on noncommunicable diseases 2010 Geneva WHO 1 162
Zhang Y. Liu L. Peng Y.L. Liu Y.Z. Wu T.Y. Shen X.L. Zhou J.R. Sun D.Y. Huang A.J. Wang X. 2013 Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors CNS Neurosci. Ther. 20 119 124 24279434
Zhou R. Tardivel A. Thorens B. Choi I. Tschopp J. 2010 Thioredoxin-interacting protein links oxidative stress to inflammasome activation Nat. Immunol. 11 136 140 20023662
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
오픈액세스 학술지에 출판된 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.