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NTIS 바로가기韓國環境保健學會誌 = Journal of environmental health sciences, v.40 no.4, 2014년, pp.265 - 278
박주형 (미국 직업안전보건연구원)
Microbes such as bacteria, fungi, archaea, protists, and viruses are ubiquitous and people are exposed to them continuously. Endotoxin is a component of the outer membrane of Gram-negative bacteria and a potent proinflammaotry substance. When a person is exposed to environmental endotoxin, an innate...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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그람음성균이 세포 외막에 함유하고 있는 성분은 무엇인가? | 인류는 항상 주변 환경 중에 존재하는 이런 미생물들에 노출되면서 생활해 왔으며, 이런 노출로부터 건강을 유지하고 환경에 적응하기 위해서 매우 섬세한 면역학 반응체계를 발전시켰다. 이들 중 그람음성균은 세포 외막에 endotoxin (이하 ‘엔도톡신’)이라는 성분을 함유하고 있다. 우리가 이들에 노출되면 우리 몸은 균의 세포벽 성분인 엔도톡신을 감지하여 즉시 선천면역반응 (innate immune system)을 개시한다. | |
염증현상의 대표적인 증상은 무엇인가? | 따라서 염증현상은 우리의 몸을 감염으로부터 일차적으로 보호하기 위한 기전으로 볼 수 있다. 이러한 염증의 대표적 증상 중의 하나가 발열이므로 엔도톡신도 발열물질(pyrogen)로 간주된다.2) 하지만 이러한 염증반응이 과도하게 일어날 경우에는 신체보호를 위한 기전이 오히려 해가 되어 내독소혈증(endotoxemia)을 유발하여 죽음에 이르게 할 수도 있다. | |
선천면역반응의 결과는 무엇인가? | 적응면역(adaptive immune system)을발동시키는데 최소 3-4일 정도 걸리므로,1) 그 사이 균이 신체 내에서 빠르게 증식하기 전에 선천 면역을 통해 1차적으로 신체를 보호한다. 선천면역반응 결과 신체는 여러 가지 염증(inflammation)과 관련된 세포들을 감염(노출)된 조직으로 모으고 면역매개 물질(cytokine)들을 분비한다. 따라서 염증현상은 우리의 몸을 감염으로부터 일차적으로 보호하기 위한 기전으로 볼 수 있다. |
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