선택한 단어 수는 입니다.
최소 단어 이상 선택하여야 합니다.
최소 단어 이상 선택하여야 합니다.
선택한 단어 수는 30입니다.
최대 10 단어까지만 선택 가능합니다.
최대 10 단어까지만 선택 가능합니다.
제안 방법
- Chemotherapy commenced concurrently with RT, and a total of 2∼3 cycles of chemotherapy were administered before surgery. All patients received 5-fluorouracil and leucovorin; 5-fluorouracil (425 mg/m2/day) was continuously infused for 5 days during the first and last weeks of RT, and leucovorin (20 mg/kg) was infused on each day of chemotherapy. Mitomycin C (10 mg/m2) was infused on day 1 in 161 patients.
- Categorical variables were compared with the chi-square test or Fisher’s exact test, and continuous ones with the student t-test for a comparison of the two groups.
- Complications were evaluated through medical records, including physical examinations, colonofiberscopy and diagnostic images. Early leakage was defined as leakage that occurred within one month after surgery and delayed anastomotic leakage was defined as leakage thereafter.
- Thus, we retrospectively analyzed the impact of HT using a capacitive type machine on postoperative complications in locally advanced rectal cancer treated with preoperative CCRT followed by curative surgery.
대상 데이터
- 8) reported the results of the phase III study, comparing RT with and without HT in locally advanced cervical, rectal and bladder cancer. A total of 358 patients were enrolled. In primary or recurrent rectal cancer patients, a total dose of 46∼50 Gy with or without a boost of 10∼24 Gy was delivered.
- The surgeon determined the type of surgery and total mesorectal excision was routinely performed. Adjuvant chemotherapy was administered in 198 patients. The same regimen as the preoperative treatment, except mitomycin C, was delivered to 164 patients for up to 12 cycles.
- In this study, 205 patients who were evaluable for acute and late toxicities after surgery were analyzed. Patients with a follow-up period of less than 6 months after surgery (n=12) or who had previous abdominal surgery history (n=5) or who received postoperative RT (n=13) were excluded.
- All patients received 5-fluorouracil and leucovorin; 5-fluorouracil (425 mg/m2/day) was continuously infused for 5 days during the first and last weeks of RT, and leucovorin (20 mg/kg) was infused on each day of chemotherapy. Mitomycin C (10 mg/m2) was infused on day 1 in 161 patients.
- 5 Gy bid) with 5-fluorouracil, given as suppositories, was given. Sixteen patients received HT using an 8-MHz capacitive type machine (Thermotron RF-8, Yamamoto Vinita, Tokyo, Japan). The mean follow-up period was 4.
이론/모형
- The complication-free survival rate was calculated from the date of surgery. Log-rank test was used to test the significance of HT for survival. Statistical evaluations were performed using the SPSS statistics 20 software (SPSS, Chicago, IL).
- Categorical variables were compared with the chi-square test or Fisher’s exact test, and continuous ones with the student t-test for a comparison of the two groups. The survival rate was calculated from the first day of CCRT to the date of the event using the Kaplan-Meier method. The complication-free survival rate was calculated from the date of surgery.
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