다낭신장병은 신장실질에 다수의 낭포가 형성되는 것을 특징으로 하는 사람, 개, 고양이에서 흔히 있는 유전성 질환으로서, 사육상태의 꼬마하마(pygmy hippopotamus)에서도 몇 몇 증례가 보고되고 있다. 2013년 1월 15일 체중 198킬로그램, 33년령 암컷 꼬마하마의 부검과정 중에 양쪽 신장에서 다낭신장병이 관찰되었다. 한 쪽 신장은 약간 종대된 반면 다른 쪽 신장의 아랫부분은 옅은 황색의 수양성 액체로 채워진 한 개의 큰 낭포가 있었다. 양측 신장 모두 직경 2 mm에서 20 mm의 다양한 크기의 액체가 함유된 다수의 낭포들이 관찰되었다. 상당한 부분의 신장 피질과 수질부가 낭포들로 대체되어 있었다. 현미경 검사에서 낭포들의 안쪽은 낮은 입방세포에서부터 편평상피세포들로 구성되어 있었다. 육안적인 소견과 조직병리학적인 검사로 다낭신장병으로 진단하였다. 본 증례보고는 한국에서 최초로 꼬마하마에서 다낭신장병이 확인된 것이다.
다낭신장병은 신장실질에 다수의 낭포가 형성되는 것을 특징으로 하는 사람, 개, 고양이에서 흔히 있는 유전성 질환으로서, 사육상태의 꼬마하마(pygmy hippopotamus)에서도 몇 몇 증례가 보고되고 있다. 2013년 1월 15일 체중 198킬로그램, 33년령 암컷 꼬마하마의 부검과정 중에 양쪽 신장에서 다낭신장병이 관찰되었다. 한 쪽 신장은 약간 종대된 반면 다른 쪽 신장의 아랫부분은 옅은 황색의 수양성 액체로 채워진 한 개의 큰 낭포가 있었다. 양측 신장 모두 직경 2 mm에서 20 mm의 다양한 크기의 액체가 함유된 다수의 낭포들이 관찰되었다. 상당한 부분의 신장 피질과 수질부가 낭포들로 대체되어 있었다. 현미경 검사에서 낭포들의 안쪽은 낮은 입방세포에서부터 편평상피세포들로 구성되어 있었다. 육안적인 소견과 조직병리학적인 검사로 다낭신장병으로 진단하였다. 본 증례보고는 한국에서 최초로 꼬마하마에서 다낭신장병이 확인된 것이다.
Polycystic kidney disease (PKD) is characterized by multiple cysts within the renal parenchyma and is a common heritable disease in humans, dogs, and cats. However, a few cases of PKD have been described in captive pygmy hippopotamuses. Bilateral PKD was observed in a 33-year-old, 198-kg female pygm...
Polycystic kidney disease (PKD) is characterized by multiple cysts within the renal parenchyma and is a common heritable disease in humans, dogs, and cats. However, a few cases of PKD have been described in captive pygmy hippopotamuses. Bilateral PKD was observed in a 33-year-old, 198-kg female pygmy hippopotamus during its necropsy in Seoul Zoo on 15 January 2013. The diagnosis of PKD was confirmed by gross findings and histopathological examination. One kidney was slightly enlarged, and the lower portion of other kidney contained a large cyst filled with light yellow, watery fluid. Both kidneys had numerous, variably sized fluid-filled cysts of 2 to 20 mm in diameter. Considerable portions of the renal cortex and medulla were replaced by cysts. Microscopic inspection showed that the cysts were lined with low cuboidal to flat epithelial cells. The present case report of PKD in a pygmy hippopotamus is the first in Korea.
Polycystic kidney disease (PKD) is characterized by multiple cysts within the renal parenchyma and is a common heritable disease in humans, dogs, and cats. However, a few cases of PKD have been described in captive pygmy hippopotamuses. Bilateral PKD was observed in a 33-year-old, 198-kg female pygmy hippopotamus during its necropsy in Seoul Zoo on 15 January 2013. The diagnosis of PKD was confirmed by gross findings and histopathological examination. One kidney was slightly enlarged, and the lower portion of other kidney contained a large cyst filled with light yellow, watery fluid. Both kidneys had numerous, variably sized fluid-filled cysts of 2 to 20 mm in diameter. Considerable portions of the renal cortex and medulla were replaced by cysts. Microscopic inspection showed that the cysts were lined with low cuboidal to flat epithelial cells. The present case report of PKD in a pygmy hippopotamus is the first in Korea.
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
제안 방법
Tissue sections were stained with hematoxylin and eosin for light microscopy examination. The diagnosis of PKD was confirmed by gross findings and histopathological examination. On necropsy, one kidney was slightly enlarged (Fig 1A).
대상 데이터
A 33-year-old, 198-kg female pygmy hippopotamus (Inter-national Studbook No. 568) was found dead on 15 January 2013 in Seoul Zoo. There were no previous clinical signs before its death.
287). At the age of 4 years, in May 1984, it was transferred to Seoul Zoo. Its male hippopotamus cage mate (International Studbook No.
There were no previous clinical signs before its death. It had been exhibited in a 519-m2 outdoor enclosure with a 132-m2 pool and a 15-m2 wallow area with a male hippopotamus since 1984, when the zoo was opened. The two animals were housed in an indoor exhibition room together during winter.
However, a few cases of PKD have been reported in exotic or wildlife species, including sturgeons (17), pandas (9), deer (1), and raccoons (4). The authors encountered PKD in a captive pygmy hippopotamus during its necropsy in Seoul Zoo.
후속연구
Although the cause of cystic disorders has not been determined, some factors may have contributed to the death of this pygmy hippopotamus. This report is the first case of PKD in a pygmy hippopotamus in Korea, and further study is needed to elucidate the pattern of occurrence of PKD in pygmy hippopotamuses.
참고문헌 (19)
Blutke A, Marz K, Matenaers C, Oswald K, Hermanns W, Wanke R. Polycystic kidney disease in a European roe deer (Capreolus capreolus). J Zoo Wildl Med 2013; 44: 487-490.
Helps C, Tasker S, Harley R. Correlation of the feline PKD1 genetic mutation with cases of PKD diagnosed by pathological examination. Exp Mol Pathol 2007; 83: 264-268.
Makungu M, du Plessis WM, Barrows M, Koeppel KN, Groenewald HB. Polycystic kidneys in the red panda (Ailurus fulgens). J Zoo Wildl Med 2013; 44: 777-780.
Maurer KJ, Marini RP, Fox JG, Rogers AB. Polycystic kidney syndrome in New Zealand White rabbits resembling human polycystic kidney disease. Kidney Int 2004; 65: 482-489.
Nees S, Schade B, Clauss M, Steinmetz HW, Ehrensperger F, Steck B, Hatt JM. Polycystic kidney disease in the pygmy hippopotamus (Hexaprotodon liberiensis). J Zoo Wildl Med 2009; 40: 529-535.
Parfrey PS, Bear JC, Morgan J, Cramer BC, McManamon PJ, Gault MH, Churchill DN, Singh M, Hewitt R, Somlo S, Reeders ST. The diagnosis and prognosis of autosomal dominant polycystic kidney disease. N Engl J Med 1990; 323: 1085-1090.
Raymond JT, Eaton KA, Monyali RJ. A disease in captive pygmy hippopotamuses (Choeropsis liberiensis) anatomically resembling polycystic kidney disease. Proc Amer Assoc Zoo Vet 2000; 302.
Roher DP, Nielsen SW. Polycystic kidneys in a western coyote. J Am Vet Med Assoc 1983; 183: 1276-1277.
Rowe I, Boletta A. Defective metabolism in polycystic kidney disease: potential for therapy and open questions. Nephrol Dial Transplant 2014; 29: 1480-1486.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.