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NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.29 no.6, 2014년, pp.63 - 71
서승희 (동신대학교 뷰티미용학과) , 배기상 (원광대학교 한방체액조절연구센터) , 최선복 (원광대학교 한의과대학 본초학교실) , 조일주 (원광대학교 한의과대학 본초학교실) , 김동구 (원광대학교 한의과대학 본초학교실) , 신준연 (원광대학교 한의과대학 본초학교실) , 송호준 (원광대학교 한의과대학 본초학교실) , 박성주 (원광대학교 한방체액조절연구센터) , 최미옥 (광주여자대학교 미용과학과)
Objectives : Lonicerae japonicae Flos(LJF) has been reported to exhibit anti-oxidant, anti-inflammatory, anti-viral, anti-rheumatoid properties. However, it is still largely unknown whether LJF inhibits the ultraviolet(UV)B-induced oxidative damage in human HaCaT keratinocytes. Therefore in this pap...
핵심어 | 질문 | 논문에서 추출한 답변 |
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피부의 기능은 무엇이 있는가? | 피부는 크게 표피, 진피, 피하조직으로 구성되어 있으며 체온조절, 보습, 감각작용, 방벽작용. 분비 및 배설작용, 호흡작용, 흡수작용, 영양소 저장 및 비타민 D합성 등 다양한 생리작용을 함으로써 정상적인 피부를 유지하는데 주된 작용을 하고 있다1). 하지만 피부 표피에 해당하는 각질형성세포(keratinocytes)는 태양광선(자외선)을 비롯한 외부 자극에 직접적으로 노출되는 최외각 층으로서 반복적으로 많은 양의 자외선에 노출되면 산화적 스트레스(oxidative stress)를 유도하여 활성산소종(reactive oxygen species, ROS)이 생성 된다2). | |
금은화는 무엇인가? | 금은화(金銀花, Lonicerae japonicae Flos, LJF)는 인동과(Caprifoliaceae)에 속하는 인동 덩굴(Lonicera japonica Thunb.)의 꽃으로서 한방에서는 利尿, 淸熱解毒, 外感風熱, 熱毒瀉痢, 健胃, 涼散風熱, 擁腫精瘡, 喉痹, 丹毒, 熱血毒痢, 風血感冒, 溫炳發熱 등에 효능을 갖고 있는 본초이다. 금은화에 대한 최근 연구 동향 분석에 따르면 감염성 질환, 외이도염, 화농증, 중이염, 바이러스성 결막염, 인플루엔자, 폐렴 등의 염증성 질병에 사용되고 있다12,13). | |
태양광선 중 피부 손상의 주원인이 되는 UVB의 파장은? | 피부는 인체의 최외각에 존재함으로서 자외선에 직접적으로 노출되기 쉬우며, 노출된 피부는 지속적으로 영향을 받게 되면, 활성산소종에 의한 광산화적 노화가 발생 된다24). 자외선 중 피부 손상의 주된 원인은 280 - 380 nm의 중파장을 갖고 있는 UVB이다. UVB는 진피의 상층부까지 도달하여 피부 내 ROS의 생성을 촉진시켜 세포에 돌연변이를 유발하고 aspartate나 glutamate와 같은 흥분성 아미노산의 분비를 촉진 시켜 단백질 기능에 손상을 유도한다25-27). |
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