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NTIS 바로가기大韓本草學會誌 = The Korea journal of herbology, v.29 no.6, 2014년, pp.73 - 83
손영하 (경희대학교 동서의학대학원 한의과학전공) , 김성재 (경희대학교 동서의학대학원 한의과학전공) , 정민찬 (경희대학교 동서의학대학원 한의과학전공) , 조동국 (경희대학교 동서의학대학원 한의과학전공) , 조우성 (경희대학교 동서의학대학원 한의과학전공) , 신정원 (경희대학교 동서의학대학원 한의과학전공) , 박동일 (동의대학교 한의과대학 내과학교실) , 손낙원 (경희대학교 동서의학대학원 한의과학전공)
Objectives : This study was investigated the effects of the root of Polygala tenuifolia (POL) on learning and memory impairment induced by chronic cerebral hypoperfusion in rats. Methods : Chronic cerebral hypoperfusion was produced by permanent bilateral common carotid artery occlusion (pBCAO). POL...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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遠志의 특징은 무엇인가? | )의 뿌리를 건조한 것으로 寧心安神, 益智, 祛痰開竅의 효능으로 心神不 安, 驚悸, 不眠, 健忘, 精神錯亂, 神志恍惚 등을 치료하는데 응용되며1), 중추신경계 질환과 인지기능 장애에 가장 많이 사용되는 한약물 중 하나이다2). 遠志는 nuclear factor-κB를 억제하는 기전에 의해 tumor necrosis factor-α와 interleukin-1을 억제하는 항염증 효능이 있고3,4), N-methyl-D-aspartate (NMDA)와 β-amyloid (Aβ)에 의한 신경세포 손상을 억제하며5,6), 1-methyl-4-phenyl-1,2,3,6 -tetrahydro-pyridine (MPTP)에 의한 도파미성 신경세포의 손상을 보호하는 효능이 있다고 하였다7). 또한 in vivo 연구에서, Aβ(25-25)의 뇌실 주입에 의한 학습과 기억 장애8) 및 무스카린성 아세틸콜린수 용체 길항제인 scopolamine에 투여에 의한 기억 장애를 개선하는 효능이 보고되었다9,10). | |
遠志 (Polygalae Radix)란 무엇인가? | 遠志 (Polygalae Radix)는 원지과 (Polygalaceae)에 속한 다년생 초본인 원지 (Polygala tenuifolia Willd.)의 뿌리를 건조한 것으로 寧心安神, 益智, 祛痰開竅의 효능으로 心神不 安, 驚悸, 不眠, 健忘, 精神錯亂, 神志恍惚 등을 치료하는데 응용되며1), 중추신경계 질환과 인지기능 장애에 가장 많이 사용되는 한약물 중 하나이다2). 遠志는 nuclear factor-κB를 억제하는 기전에 의해 tumor necrosis factor-α와 interleukin-1을 억제하는 항염증 효능이 있고3,4), N-methyl-D-aspartate (NMDA)와 β-amyloid (Aβ)에 의한 신경세포 손상을 억제하며5,6), 1-methyl-4-phenyl-1,2,3,6 -tetrahydro-pyridine (MPTP)에 의한 도파미성 신경세포의 손상을 보호하는 효능이 있다고 하였다7). | |
혈관성 치매는 어떻게 개념이 확장되었는가? | 혈관성 치매는 뇌혈관 질환에 의해 뇌조직이 손상되어 치매가 유발되는 상태로, 뇌졸중 이후 다발성 뇌경색으로 인지 장애가 유발되므로 다경색 치매 (multiinfarct dementia)라 고도 불렸다12). 그러나 다발성 뇌경색뿐만 아니라 인지기능과 관련된 뇌 부위의 단일 뇌경색, 다발성 열공, 피질하 소혈관 질환, 여러 형태의 뇌출혈 등도 치매를 초래할 수 있다는 사실이 알려지면서 다양한 뇌혈관 질환에 의해 초래되는 치매를 모두 포함하는 개념으로 확장되었다13). 최근에는 명확한 치매 뿐만 아니라 준임상적 (subclinical) 경미한 인지기능 저하까지를 포함하여 비정상적인 뇌혈류 저하에 의한 인지장애를 혈관성 인지장애 (vascular cognitive impairment, VCI)로 정의하고 있다14). |
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