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Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients - A randomized, double-blind, placebo-controlled study 원문보기

Journal of ginseng research = 高麗人參學會誌, v.39 no.1, 2015년, pp.7 - 13  

Bae, Hyoung Won (Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine) ,  Kim, Ji Hyun (Siloam Eye Hospital) ,  Kim, Sangah (Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine) ,  Kim, Minkyo (Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine) ,  Lee, Naeun (Department of Ophthalmology, Hallym Hospital) ,  Hong, Samin (Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine) ,  Seong, Gong Je (Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine) ,  Kim, Chan Yun (Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine)

Abstract AI-Helper 아이콘AI-Helper

Background: Many patients with glaucoma have difficulty using antiglaucoma eye drops because of dry eye symptom. In this prospective, randomized, double-blind, placebo-controlled study, we evaluated the effect of Korean Red Ginseng on dry eye syndrome in patients with glaucoma treated with antiglauc...

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참고문헌 (61)

  1. 1 Resnikoff S. Pascolini D. Etya'ale D. Kocur I. Pararajasegaram R. Pokharel G.P. Mariotti S.P. Global data on visual impairment in the year 2002 Bull World Health Organ 82 2004 844 851 15640920 

  2. 2 Pizzarello L. Abiose A. Ffytche T. Duerksen R. Thulasiraj R. Taylor H. Faal H. Rao G. Kocur I. Resnikoff S. VISION 2020: the Right to Sight: a global initiative to eliminate avoidable blindness Arch Ophthal 122 2004 615 620 15078680 

  3. 3 Gordon M.O. Beiser J.A. Brandt J.D. Heuer D.K. Higginbotham E.J. Johnson C.A. Keltner J.L. Miller J.P. Parrish R.K. 2nd Wilson M.R. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma Arch Ophthal 120 2002 714 720 12049575 

  4. 4 Higginbotham E.J. Schuman J.S. Goldberg I. Gross R.L. VanDenburgh A.M. Chen K. Whitcup S.M. One-year, randomized study comparing bimatoprost and timolol in glaucoma and ocular hypertension Arch Ophthal 120 2002 1286 1293 12365906 

  5. 5 Camras C.B. Comparison of latanoprost and timolol in patients with ocular hypertension and glaucoma: a six-month masked, multicenter trial in the United States. The United States Latanoprost Study Group Ophthalmology 103 1996 138 147 8628544 

  6. 6 Garcia-Feijoo J. Sampaolesi J.R. A multicenter evaluation of ocular surface disease prevalence in patients with glaucoma Clin Ophthalmol 6 2012 441 446 22536034 

  7. 7 Fechtner R.D. Godfrey D.G. Budenz D. Stewart J.A. Stewart W.C. Jasek M.C. Prevalence of ocular surface complaints in patients with glaucoma using topical intraocular pressure-lowering medications Cornea 29 2010 618 621 20386433 

  8. 8 Rossi G.C. Tinelli C. Pasinetti G.M. Milano G. Bianchi P.E. Dry eye syndrome-related quality of life in glaucoma patients Eur J Ophthalmol 19 2009 572 579 19551671 

  9. 9 Stewart W.C. Stewart J.A. Nelson L.A. Ocular surface disease in patients with ocular hypertension and glaucoma Curr Eye Res 36 2011 391 398 21501071 

  10. 10 Leung E.W. Medeiros F.A. Weinreb R.N. Prevalence of ocular surface disease in glaucoma patients J Glaucoma 17 2008 350 355 18703943 

  11. 11 Narayanan S. Miller W.L. McDermott A.M. Conjunctival cytokine expression in symptomatic moderate dry eye subjects Invest Ophthalmol Vis Sci 47 2006 2445 2450 16723455 

  12. 12 Pflugfelder S.C. Jones D. Ji Z. Afonso A. Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca Curr Eye Res 19 1999 201 211 10487957 

  13. 13 Massingale M.L. Li X. Vallabhajosyula M. Chen D. Wei Y. Asbell P.A. Analysis of inflammatory cytokines in the tears of dry eye patients Cornea 28 2009 1023 1027 19724208 

  14. 14 Yoon K.C. Jeong I.Y. Park Y.G. Yang S.Y. Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome Cornea 26 2007 431 437 17457192 

  15. 15 Lam H. Bleiden L. de Paiva C.S. Farley W. Stern M.E. Pflugfelder S.C. Tear cytokine profiles in dysfunctional tear syndrome Am J Ophthalmol 147 2009 198 205 18992869 

  16. 16 Pflugfelder S.C. Antiinflammatory therapy for dry eye Am J Ophthalmol 137 2004 337 342 14962426 

  17. 17 Jeon B.H. Kim C.S. Kim H.S. Park J.B. Nam K.Y. Chang S.J. Effect of Korean red ginseng on blood pressure and nitric oxide production Acta Pharmacol Sin 21 2000 1095 1100 11603282 

  18. 18 Jin Y.R. Yu J.Y. Lee J.J. You S.H. Chung J.H. Noh J.Y. Im J.H. Han X.H. Kim T.J. Shin K.S. Antithrombotic and antiplatelet activities of Korean red ginseng extract Basic Clin Pharmacol Toxicol 100 2007 170 175 17309520 

  19. 19 Sung J. Han K.H. Zo J.H. Park H.J. Kim C.H. Oh B.H. Effects of red ginseng upon vascular endothelial function in patients with essential hypertension Am J Chin Med 28 2000 205 216 10999439 

  20. 20 Bae E.A. Hyun Y.J. Choo M.K. Oh J.K. Ryu J.H. Kim D.H. Protective effect of fermented red ginseng on a transient focal ischemic rats Arch Pharm Res 27 2004 1136 1140 15595417 

  21. 21 Kwak Y.S. Kyung J.S. Kim J.S. Cho J.Y. Rhee M.H. Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng Biol Pharm Bull 33 2010 468 472 20190411 

  22. 22 Hwang S.Y. Son D.J. Kim I.W. Kim D.M. Sohn S.H. Lee J.J. Kim S.K. Korean red ginseng attenuates hypercholesterolemia-enhanced platelet aggregation through suppression of diacylglycerol liberation in high-cholesterol-diet-fed rabbits Phytother Res 22 2008 778 783 18446850 

  23. 23 Oh K.J. Chae M.J. Lee H.S. Hong H.D. Park K. Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study J Sex Med 7 2010 1469 1477 20141583 

  24. 24 Heo J.H. Lee S.T. Chu K. Oh M.J. Park H.J. Shim J.Y. Kim M. An open-label trial of Korean red ginseng as an adjuvant treatment for cognitive impairment in patients with Alzheimer's disease Eur J Neurol 15 2008 865 868 18684311 

  25. 25 Babayigit A. Olmez D. Karaman O. Bagriyanik H.A. Yilmaz O. Kivcak B. Erbil G. Uzuner N. Ginseng ameliorates chronic histopathologic changes in a murine model of asthma Allergy Asthma Proc 29 2008 493 498 18611306 

  26. 26 Baek N.I. Kim D.S. Lee Y.H. Park J.D. Lee C.B. Kim S.I. Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng Planta Med 62 1996 86 87 8720394 

  27. 27 Kunert K.S. Tisdale A.S. Stern M.E. Smith J.A. Gipson I.K. Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes Arch Ophthal 118 2000 1489 1496 11074805 

  28. 28 Sall K. Stevenson O.D. Mundorf T.K. Reis B.L. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group Ophthalmology 107 2000 631 639 10768324 

  29. 29 Kim N.R. Kim J.H. Kim C.Y. Effect of Korean red ginseng supplementation on ocular blood flow in patients with glaucoma J Ginseng Res 34 2010 237 245 

  30. 30 Lemp M.A. Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes CLAO J 21 1995 221 232 8565190 

  31. 31 Schiffman R.M. Christianson M.D. Jacobsen G. Hirsch J.D. Reis B.L. Reliability and validity of the Ocular Surface Disease Index Arch Ophthal 118 2000 615 621 10815152 

  32. 32 Jaenen N. Baudouin C. Pouliquen P. Manni G. Fiqueiredo A. Zeyen T. Ocular symptoms and signs with preserved and preservative-free glaucoma medications Eur J Opthalmol 17 2007 341 349 

  33. 33 Baudouin C. Labbe A. Liang H. Pauly A. Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly Prog Retin Eye Res 29 2010 312 334 20302969 

  34. 34 Noecker R.J. Herrygers L.A. Anwaruddin R. Corneal and conjunctival changes caused by commonly used glaucoma medications Cornea 23 2004 490 496 15220734 

  35. 35 Guenoun J.M. Baudouin C. Rat P. Pauly A. Warnet J.M. Brignole-Baudouin F. In vitro study of inflammatory potential and toxicity profile of latanoprost, travoprost, and bimatoprost in conjunctiva-derived epithelial cells Invest Ophthalmol Vis Sci 46 2005 2444 2450 15980234 

  36. 36 Debbasch C. Brignole F. Pisella P.J. Warnet J.M. Rat P. Baudouin C. Quaternary ammoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells Invest Ophthalmol Vis Sci 42 2001 642 652 11222522 

  37. 37 Okada Y. Effects of topical antiglaucoma medications on corneal epithelium as evaluated by gene expression patterns Cornea 26 2007 S46 S54 17881916 

  38. 38 Baudouin C. Pisella P.J. Fillacier K. Goldschild M. Becquet F. De Saint Jean M. Bechetoille A. Ocular surface inflammatory changes induced by topical antiglaucoma drugs: human and animal studies Ophthalmology 106 1999 556 563 10080214 

  39. 39 Pisella P.J. Debbasch C. Hamard P. Creuzot-Garcher C. Rat P. Brignole F. Baudouin C. Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study Invest Ophthalmol Vis Sci 45 2004 1360 1368 15111589 

  40. 40 Xiong C. Chen D. Liu J. Liu B. Li N. Zhou Y. Liang X. Ma P. Ye C. Ge J. A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride Invest Ophthalmol Vis Sci 49 2008 1850 1856 18436819 

  41. 41 Rivas L. Oroza M.A. Perez-Esteban A. Murube-del-Castillo J. Morphological changes in ocular surface in dry eyes and other disorders by impression cytology Graefes Arch Clin Exp Ophthalmol 230 1992 329 334 1505763 

  42. 42 Hikichi T. Yoshida A. Tsubota K. Lymphocytic infiltration of the conjunctiva and the salivary gland in Sjogren's syndrome Arch Ophthal 111 1993 21 22 8424715 

  43. 43 Stern M.E. Gao J. Schwalb T.A. Ngo M. Tieu D.D. Chan C.C. Reis B.L. Whitcup S.M. Thompson D. Smith J.A. Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye Invest Ophthalmol Vis Sci 43 2002 2609 2614 12147592 

  44. 44 Tsubota K. Fujihara T. Saito K. Takeuchi T. Conjunctival epithelium expression of HLA-DR in dry eye patients Ophthalmologica 213 1999 16 19 9838252 

  45. 45 Grus F.H. Dick B. Augustin A.J. Pfeiffer N. Analysis of the antibody repertoire in tears of dry-eye patients Ophthalmologica 215 2001 430 434 11741110 

  46. 46 Rand A.L. Asbell P.A. Nutritional supplements for dry eye syndrome Curr Opin Ophthalmol 22 2011 279 282 21597374 

  47. 47 Barabino S. Rolando M. Camicione P. Ravera G. Zanardi S. Giuffrida S. Calabria G. Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component Cornea 22 2003 97 101 12605039 

  48. 48 Aragona P. Bucolo C. Spinella R. Giuffrida S. Ferreri G. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren's syndrome patients Invest Ophthalmol Vis Sci 46 2005 4474 4479 16303936 

  49. 49 Macri A. Giuffrida S. Amico V. Iester M. Traverso C.E. Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy Graefes Arch Clin Exp Ophthalmol 241 2003 561 566 12768289 

  50. 50 Park B.G. Jung H.J. Cho Y.W. Lim H.W. Lim C.J. Potentiation of antioxidative and anti-inflammatory properties of cultured wild ginseng root extract through probiotic fermentation J Pharm Pharmacol 65 2013 457 464 23356855 

  51. 51 Abdel-Wahhab M.A. Ahmed H.H. Protective effects of Korean Panax ginseng against chromium VI toxicity and free radical generation in rat J Ginseng Res 28 2004 11 17 

  52. 52 Lee S.H. Jung B.H. Kim S.Y. Lee E.H. Chung B.C. The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress Pharmacol Res 54 2006 46 49 16530422 

  53. 53 Cho W.C. Chung W.S. Lee S.K. Leung A.W. Cheng C.H. Yue K.K. Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats Eur J Pharmacol 550 2006 173 179 17027742 

  54. 54 Song S.B. Tung N.H. Quang T.H. Nqan N.T. Kim K.E. Kim Y.H. Inhibition of TNF-alpha-mediated NF-kappaB Transcriptional Activity in HepG2 Cells by Dammarane-type Saponins from Panax ginseng Leaves J Ginseng Res 36 2012 146 152 23717114 

  55. 55 Ly S. Yi P.F. Shen H.Q. Zhang L.Y. Dong H.B. Wu S.C. Xia F. Guo X. Wei X.B. Fu B.D. Ginsenoside Rh2-B1 stimulates cell proliferation and IFN-gamma production by activating the p38 MAPK and ERK-dependent signaling pathways in CTLL-2 cells Immunopharmacol Immunotoxicol 36 2014 43 51 24294901 

  56. 56 Lee I.A. Hyam S.R. Jang S.E. Han M.J. Kim D.H. Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages J Agric Food Chem 60 2012 9595 9602 22849695 

  57. 57 Attele A.S. Wu J.A. Yuan C.S. Ginseng pharmacology: multiple constituents and multiple actions Biochem Pharmacol 58 1999 1685 1693 10571242 

  58. 58 Kim W.K. Song S.Y. Oh W.K. Kaewsuwan S. Tran T.L. Kim W.S. Sung J.H. Wound-healing effect of ginsenoside Rd from leaves of Panax ginseng via cyclic AMP-dependent protein kinase pathway Eur J Pharmacol 702 2013 285 293 23399764 

  59. 59 Zang Y.X. Wang L. Xiao E.L. Li S.J. Chen J.J. Gao B. Min G.N. Wang Z.P. Wu Y.J. Ginsenoside-Rd exhibits anti-inflammatory activities through elevation of antioxidant enzyme activities and inhibition of JNK and ERK activation in vivo Int Immunopharmacol 17 2013 1094 1100 24455777 

  60. 60 Her Y. Lim J.W. Han S.H. Dry eye and tear film functions in patients with psoriasis Jpn J Ophthalmol 57 2013 341 346 23525680 

  61. 61 Shimazaki-Den S. Dogru M. Higa K. Shimazaki J. Symptoms, visual function, and mucin expression of eyes with tear film instability Cornea 32 2013 1211 1218 23846406 

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