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Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions 원문보기

Journal of ginseng research = 高麗人參學會誌, v.39 no.1, 2015년, pp.61 - 68  

Yang, Yanyan (Department of Genetic Engineering, Sungkyunkwan University) ,  Lee, Jongsung (Department of Dermatological Health Management, Eulji University) ,  Rhee, Man Hee (College of Veterinary Medicine, Kyungpook National University) ,  Yu, Tao (Department of Genetic Engineering, Sungkyunkwan University) ,  Baek, Kwang-Soo (Department of Genetic Engineering, Sungkyunkwan University) ,  Sung, Nak Yoon (Department of Genetic Engineering, Sungkyunkwan University) ,  Kim, Yong (Department of Genetic Engineering, Sungkyunkwan University) ,  Yoon, Keejung (Department of Genetic Engineering, Sungkyunkwan University) ,  Kim, Ji Hye (Department of Genetic Engineering, Sungkyunkwan University) ,  Kwak, Yi-Seong (Ginseng Corporation Central Research Institute) ,  Hong, Sungyoul (Department of Genetic Engineering, Sungkyunkwan University) ,  Kim, Jong-Hoon (Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University) ,  Cho, Jae Youl (Department of Genetic Engineering, Sungkyunkwan University)

Abstract ▼ AI-Helper 아이콘AI-Helper

Background: Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only a few studies have explored the molecular mechanism of KRG-mediated an...

주제어

#activating transcription factor 2   #anti-inflammatory activity   #interferon regulatory transcription factor 3   #Korean red ginseng   #protopanaxadiol saponin fraction  

참고문헌 (40)

  1. 1 Sodenkamp J. Behrends J. Forster I. Muller W. Ehlers S. Holscher C. gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis Eur J Cell Biol 90 2011 505 514 21144615 

    상세보기

  2. 2 Roberts-Thomson I.C. Fon J. Uylaki W. Cummins A.G. Barry S. Cells, cytokines and inflammatory bowel disease: a clinical perspective Expert Rev Gastroenterol Hepatol 5 2011 703 716 22017698 

  3. 3 Ribeiro-Gomes F.L. Silva M.T. Dosreis G.A. Neutrophils, apoptosis and phagocytic clearance: an innate sequence of cellular responses regulating intramacrophagic parasite infections Parasitology 132 Suppl. 2006 S61 S68 17018166 

  4. 4 Yu T. Yi Y.S. Yang Y. Oh J. Jeong D. Cho J.Y. The pivotal role of TBK1 in inflammatory responses mediated by macrophages Mediators Inflamm 2012 2012 979105 http://dx.doi.org/10.1155/2012/979105 23304064 

  5. 5 Byeon S.E. Yi Y.S. Oh J. Yoo B.C. Hong S. Cho J.Y. The role of Src kinase in macrophage-mediated inflammatory responses Mediators Inflamm 2012 2012 512926 http://dx.doi.org/10.1155/2012/512926 23209344 

  6. 6 Jeon J.W. Park B.C. Jung J.G. Jang Y.S. Shin E.C. Park Y.W. The soluble form of the cellular prion protein enhances phagocytic activity and cytokine production by human monocytes via activation of ERK and NF-kappaB Immune Netw 13 2013 148 156 24009542 

  7. 7 Chiurchiu V. Maccarrone M. Chronic inflammatory disorders and their redox control: from molecular mechanisms to therapeutic opportunities Antioxid Redox Signal 15 2011 2605 2641 21391902 

    상세보기

  8. 8 Przemyslaw L. Boguslaw H.A. Elzbieta S. Malgorzata S.M. ADAM and ADAMTS family proteins and their role in the colorectal cancer etiopathogenesis BMB Rep 46 2013 139 150 23527857 

    원문보기 상세보기

  9. 9 Kang D.H. Kang S.W. Targeting cellular antioxidant enzymes for treating atherosclerotic vascular disease Biomol Ther (Seoul) 21 2013 89 96 24009865 

  10. 10 Baeg I.H. So S.H. The world ginseng market and the ginseng (Korea) J Ginseng Res 37 2013 1 7 23717152 

  11. 11 Byeon S.E. Lee J. Kim J.H. Yang W.S. Kwak Y.-S. Kim S.Y. Choung E.S. Rhee M.H. Cho J.Y. Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng Mediators Inflamm 2012 2012 732860 http://dx.doi.org/10.1155/2012/732860 22474399 

  12. 12 Yayeh T. Jung K.H. Jeong H.Y. Park J.H. Song Y.B. Kwak Y.S. Kang H.S. Cho J.Y. Oh J.W. Kim S.K. Korean Red Ginseng saponin fraction downregulates proinflammatory mediators in LPS stimulated RAW264.7 cells and protects mice against endotoxic shock J Ginseng Res 36 2012 263 269 23717127 

  13. 13 Kim H.A. Kim S. Chang S.H. Hwang H.J. Choi Y.N. Anti-arthritic effect of ginsenoside Rb1 on collagen induced arthritis in mice Int Immunopharmacol 7 2007 1286 1291 17673143 

    상세보기

  14. 14 Kim J.H. Kang S.A. Han S.M. Shim I. Comparison of the antiobesity effects of the protopanaxadiol- and protopanaxatriol-type saponins of red ginseng Phytother Res 23 2009 78 85 18709638 

  15. 15 Kim M.H. Son Y.J. Lee S.Y. Yang W.S. Yi Y.S. Yoon D.H. Yang Y. Kim S.H. Lee D. Rhee M.H. JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide Biochem Pharmacol 86 2013 1747 1761 24144632 

    상세보기

  16. 16 Kim M.H. Yoo D.S. Lee S.Y. Byeon S.E. Lee Y.G. Min T. Rho H.S. Rhee M.H. Lee J. Cho J.Y. The TRIF/TBK1/IRF-3 activation pathway is the primary inhibitory target of resveratrol, contributing to its broad-spectrum anti-inflammatory effects Pharmazie 66 2011 293 300 21612158 

    상세보기

  17. 17 Cho J.Y. Baik K.U. Jung J.H. Park M.H. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa Eur J Pharmacol 398 2000 399 407 10862830 

    상세보기

  18. 18 Green L.C. Wagner D.A. Glogowski J. Skipper P.L. Wishnok J.S. Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Anal Biochem 126 1982 131 138 7181105 

    상세보기

  19. 19 Gerlier D. Thomasset N. Use of MTT colorimetric assay to measure cell activation J Immunol Methods 94 1986 57 63 3782817 

    상세보기

  20. 20 Hong Y.J. Yang K.S. Anti-inflammatory activities of crocetin derivatives from processed Gardenia jasminoides Arch Pharm Res 36 2013 933 940 23636885 

    상세보기

  21. 21 Kang T.H. Park H.M. Kim Y.B. Kim H. Kim N. Do J.H. Kang C. Cho Y. Kim S.Y. Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice J Ethnopharmacol 123 2009 446 451 19501277 

    상세보기

  22. 22 Kim I.W. Sun W.S. Yun B.S. Kim N.R. Min D. Kim S.K. Characterizing a full spectrum of physico-chemical properties of (20S)- and (20R)-ginsenoside Rg3 to be proposed as standard reference materials J Ginseng Res 37 2013 124 134 23717166 

  23. 23 Zhang R. Zhu J. Cao H.-Z. Xie X.-L. Huang J.-J. Chen X.-H. Luo Z.-Y. Isolation and characterization of LHT-type plant amino acid transporter gene from Panax ginseng Meyer J Ginseng Res 37 2013 361 370 24198663 

  24. 24 Park Y.J. Kim M.J. Kim H.R. Yi M.S. Chung K.H. Oh S.M. Chemopreventive effects of Ginkgo biloba extract in estrogen-negative human breast cancer cells Arch Pharm Res 36 2013 102 108 23335025 

    상세보기

  25. 25 Back S.S. Kim J. Choi D. Lee E.S. Choi S.Y. Han K. Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor BMB Rep 46 2013 322 327 23790976 

    원문보기 상세보기

  26. 26 Yu T. Ahn H.M. Shen T. Yoon K. Jang H.J. Lee Y.J. Yang H.M. Kim J.H. Kim C. Han M.H. Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans J Ethnopharmacol 137 2011 1197 1206 21821108 

    상세보기

  27. 27 Kim E.H. Lee M.J. Kim I.H. Pyo S. Choi K.T. Rhee D.K. Anti-apoptotic effects of red ginseng on oxidative stress induced by hydrogen peroxide in SK-N-SH cells J Ginseng Res 34 2010 138 144 

  28. 28 Lee J.Y. Lee Y.G. Lee J. Yang K.J. Kim A.R. Kim J.Y. Won M.H. Park J. Yoo B.C. Kim S. Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects J Biol Chem 285 2010 9932 9948 20054000 

    상세보기

  29. 29 Lee Y. Kim J. Jang S. Oh S. Administration of phytoceramide enhances memory and upregulates the expression of pCREB and BDNF in hippocampus of mice Biomol Ther (Seoul) 21 2013 229 233 24265869 

  30. 30 Okabe S. Miyake H. Awane Y. Cytoprotective effects of NC-1300 and omeprazole on Hcl. ethanol-induced gastric lesions in rats Jpn J Pharmacol 42 1986 123 133 3795613 

  31. 31 Lee S.-J. Park J.-Y. Choi K.-S. Ock C.-Y. Hong K.-S. Kim Y.-J. Chung J.-W. Hahm K.-B. Efficacy of Korean red ginseng supplementation on eradication rate and gastric volatile sulfur compound levels after Helicobacter pylori eradication therapy J Ginseng Res 34 2010 122 131 

  32. 32 Yang Y. Yang W.S. Yu T. Sung G.H. Park K.W. Yoon K. Son Y.J. Hwang H. Kwak Y.S. Lee C.M. ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract J Ethnopharmacol 154 2014 218 228 24735861 

    상세보기

  33. 33 Bak M.J. Hong S.G. Lee J.W. Jeong W.S. Red ginseng marc oil inhibits iNOS and COX-2 via NFkappaB and p38 pathways in LPS-stimulated RAW 264.7 macrophages Molecules 17 2012 13769 13786 23174895 

  34. 34 Dou L. Lu Y. Shen T. Huang X. Man Y. Wang S. Li J. Panax notogingseng saponins suppress RAGE/MAPK signaling and NF-kappaB activation in apolipoprotein-E-deficient atherosclerosis-prone mice Cell Physiol Biochem 29 2012 875 882 22613987 

    상세보기

  35. 35 Yang Y. Kim S.C. Yu T. Yi Y.S. Rhee M.H. Sung G.H. Yoo B.C. Cho J.Y. Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses Mediators Inflamm 2014 2014 352371 http://dx.doi.org/10.1155/2014/352371 24771982 

  36. 36 Clark K. Plater L. Peggie M. Cohen P. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation J Biol Chem 284 2009 14136 14146 19307177 

  37. 37 Yan L. Liu S. Wang C. Wang F. Song Y. Yan N. Xi S. Liu Z. Sun G. JNK and NADPH oxidase involved in fluoride-induced oxidative stress in BV-2 microglia cells Mediators Inflamm 2013 2013 895975 http://dx.doi.org/10.1155/2013/895975 24072958 

  38. 38 Kersting S. Behrendt V. Kersting J. Reinecke K. Hilgert C. Stricker I. Herdegen T. Janot M.S. Uhl W. Chromik A.M. The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium J Inflamm Res 6 2013 71 81 23667316 

    상세보기

  39. 39 Abe T. Barber G.N. Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-kappaB activation through TBK1 J Virol 88 2014 5328 5341 24600004 

  40. 40 Jung J.H. Kang I.G. Kim D.Y. Hwang Y.J. Kim S.T. The effect of Korean red ginseng on allergic inflammation in a murine model of allergic rhinitis J Ginseng Res 37 2013 167 175 23717169 

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