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논문 상세정보

천연방부제로 사용된 한약재의 항균활성에 대한 동향 분석

Investigation of Anti-microbial Activity of Herbal Medicines Used as Natural Preservatives Based on the Analysis of Papers and Patents

Abstract

Application of herbal medicines as natural preservatives has been increased because of its low toxicity or side effect, compared to artificial preservatives. In this study, papers and patents researching anti-microbial activity of herbal medicine were collected and analyzed by the year of publishment, species of bacteria, fungi, or yeasts, and herbal medicines used. After early 2000's, the number of paper publishment has been decreased, while that of patent registration has been increased up to early 2010's. Most studied species were Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa, as gram-positive or gram-negative bacteria, and Candida albicans and Aspergillus niger as fungi. The bark of Cinnamomum cassia (L.) J. Presl was most frequently studies herbal medicine, followed by the roots of Scutellaria baicalensis Georgi and Sophora flavescens Ait. This study demonstrates that herbal medicines can be used as natural preservatives against diverse species of bacteria, fungi, or yeasts with their wide-ranged anti-microbial activities.

질의응답 

키워드에 따른 질의응답 제공
핵심어 질문 논문에서 추출한 답변
합성방부제인 파레벤류(parabens)
합성방부제인 파레벤류(parabens)가 첨가된 화장품을 장기간 사용할 시에 발생할 수 있는 문제점은 무엇인가?
합성방부제인 파레벤류(parabens)의 경우 여성 호르몬의 일종인 에스트로겐과 유사한 작용을 하는 것으로 알려져 있는데, 이는 기준치내의 사용이라도 장기간 사용에 따른 지속적 체내 축적 시 내분비계 교란물질로 작용할 수도 있음을 시사한다

그러나 범용적으로 사용되는 이러한 합성방부제들은 장기간동안 고농도로 사용 시 피부알러지, 내성균 유발, 환경호르몬으로서의 가능성 등의 다양한 문제들이 발생할 가능성이 높다5,6). 예를 들면, 가장 널리 사용되던 합성방부제인 파레벤류(parabens)의 경우 여성 호르몬의 일종인 에스트로겐과 유사한 작용을 하는 것으로 알려져 있는데, 이는 기준치내의 사용이라도 장기간 사용에 따른 지속적 체내 축적 시 내분비계 교란물질로 작용할 수도 있음을 시사한다7).

천연방부제 후보
천연방부제 후보가 갖추어야할 요건들은 무엇인가?
다양한 항균스펙트럼을 지니며 안전성과 경제성이 높으며 제품화 개발이 가능한

확대된 글로벌 유통시장에 따라 방부용 첨가물의 사용이 지속적으로 증가함에 따라 이러한 화학적 합성방부제의 부작용을 극복할 수 있는 합성방부제 대체제 개발의 필요성이 증가하면서 다양한 항균스펙트럼을 지니며 안전성과 경제성이 높으며 제품화 개발이 가능한 천연방부제 개발의 필요성이 대두되었다. 이에 따라 alkaloids, flavonoids, phytoalexin 등과 같은 천연항균물질을 천연방부제로 사용하기 위한 많은 연구들이 진행되어왔다8).

황색포도상구균(S. aureus)
황색포도상구균(S. aureus)이 무엇인가?
식중독 원인균 중 하나로 환경 저항성이 강하고 내열성 장독소(enterotoxin)을 생성하여 구토, 설사 등의 식중독 증상을 일으키는 주요 원인으로 알려져 있을 뿐만 아니라, 눈에서 가장 많이 발견되는 균 중의 하나로 정상적인 피부와 결막을 포함한 점막에 상주하여 손상된 각막에 감염을 일으키거나 심하면 주변부 궤양을 유발한다

황색포도상구균(S. aureus)은 식중독 원인균 중 하나로 환경 저항성이 강하고 내열성 장독소(enterotoxin)을 생성하여 구토, 설사 등의 식중독 증상을 일으키는 주요 원인으로 알려져 있을 뿐만 아니라, 눈에서 가장 많이 발견되는 균 중의 하나로 정상적인 피부와 결막을 포함한 점막에 상주하여 손상된 각막에 감염을 일으키거나 심하면 주변부 궤양을 유발한다57,58). 고초균(B.

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