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[국내논문] A Molecular Mucosal Adjuvant To Enhance Immunity Against Pneumococcal Infection In The Elderly 원문보기

Immune network : official journal of the Korean association of immunobiologists, v.15 no.1, 2015년, pp.9 - 15  

Fukuyama, Yoshiko (Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo) ,  Ikeda, Yorihiko (Department of Pediatric Dentistry, The University of Alabama at Birmingham) ,  Ohori, Junichiro (Department of Pediatric Dentistry, The University of Alabama at Birmingham) ,  Sugita, Gen (Department of Pediatric Dentistry, The University of Alabama at Birmingham) ,  Aso, Kazuyoshi (Department of Pediatric Dentistry, The University of Alabama at Birmingham) ,  Fujihashi, Keiko (Department of Pediatric Dentistry, The University of Alabama at Birmingham) ,  Briles, David E. (Department of Microbiology, The University of Alabama at Birmingham) ,  McGhee, Jerry R. (Department of Pediatric Dentistry, The University of Alabama at Birmingham) ,  Fujihashi, Kohtaro (Department of Pediatric Dentistry, The University of Alabama at Birmingham)

Abstract AI-Helper 아이콘AI-Helper

Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective mucosal immunity against this pathogen in order to prevent pnuemocaccal infection. However, this i...

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가설 설정

  • IL-15 treatment also restored impaired DC function in mesenteric lymph nodes of aged mice (66). Taken together, we hypothesize that mucosal delivery of DC-targeting pFL and CpG ODN as a mucosal adjuvant, would elicit Ag-specific SIgA Ab responses in the elderly against S. pneumonia infection.
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참고문헌 (66)

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