[논문]A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis

Kim, Hyejin; Rather, Irfan A.; Kim, Hyunwook; Kim, Sungsoo; Kim, Taeeun; Jang, Jaeyoung; Seo, Jimin; Lim, Jeongheui; Park, Yong-Ha

doi:10.4014/jmb.1506.06065

A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis 원문보기

Journal of microbiology and biotechnology, v.25 no.11, 2015년, pp.1966 - 1969

Kim, Hyejin (Haemaru Referral Animal Hospital) , Rather, Irfan A. (Department of Applied Microbiology and Biotechnology, Yeungnam University) , Kim, Hyunwook (Haemaru Referral Animal Hospital) , Kim, Sungsoo (Haemaru Referral Animal Hospital) , Kim, Taeeun (Haemaru Referral Animal Hospital) , Jang, Jaeyoung (Haemaru Referral Animal Hospital) , Seo, Jimin (Haemaru Referral Animal Hospital) , Lim, Jeongheui (National Science Museum Ministry of Science, ICT and Future Planning) , Park, Yong-Ha (Department of Applied Microbiology and Biotechnology, Yeungnam University)

Abstract ▼ AI-Helper

Canine atopic dermatitis (CAD) is a ubiquitous, chronic inflammatory skin disorder prevalent in dogs, which results in production of abnormal levels of IgE antibodies in reciprocation to an allergen challenge. In this study, administration of the probiotic strain Lactobacillus sakei probio-65 for 2 months significantly reduced the disease severity index in experimental dogs diagnosed with CAD. In addition, one month pre-medication of L. sakei probio-65 revealed significant difference in the PVAS score in experimental dogs for both probio-65 and placebo groups. However, post 2 months treatment resulted in a significant decrease in the CASESI score values in the probio-65-treated group (p < .0.06).

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The study was performed on a group of 42 dogs with confirmatory clinical diagnosis of canine atopic dermatitis. However, four dogs were excluded from the final study owing to mismanagement in monitoring the diet intake.

이론/모형

Non-parametric methods were used for univariate analyses due to dependent variables of the non-Gaussian distribution, which were treated as continuous variables. Therefore, comparisons between groups have been tested using the non-parametric Mann-Whitney test.

성능/효과

sakei probio-65 against CAD symptoms. Based on the above findings, it could be concluded that the administration of L.sakei probio-65 resulted in improvement of the symptoms of CAD in all experimental dogs. The treatment reduced the CADESI and PVASI scores following 2 months of treatment without any adversary side effects.
06). Post 2 months, the CADESI score decreased further to 16.36% in the L. sakei probio-65 administration test group and 7.27% in the placebo group (p=0.006). No significant difference was observed in between pre-treatment values and 1 month treatment CADESI scores; the mean or percentage difference between pre-treatment values and post 2 months CADESI values significantly increased in the L.
The average PVAS score values for the 28 dogs in the test group and 10 dogs in the placebo group at the pre-treatment visit were found to be 7.04 and 4.50, respectively. Administration of L.

참고문헌 (13)

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Fazakerley J, Nuttal T, Sales D, Schmidt V, Carter SD, Hart McEwan NA. 2009. Staphylococcal colonization of mucosal and lesional skin sites in atopic and healthy dogs. Vet. Dermatol. 20: 179-184.

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Hillier A, Griffin CE. 2001. The ACVD task force on canine atopic dermatitis (X): is there a relationship between canine atopic dermatitis and cutaneous adverse food reactions? Vet. Immunol. Immunopathol. 81: 227-231.

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Kang JS, Yoon WK, Han MH, Lee H, Lee CW, Lee KH, et al. 2008. Inhibition of atopic dermatitis by topical application of silymarin in NC Nga mice. Int. Immunopharmacol. 8: 1475-1480.

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Linek M, Favrot C. 2010. Impact of canine atopic dermatitis on the health-related quality of life of affected dogs and quality of life of their owners. Vet. Dermatol. 21: 456-462.

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Marsella R, Santoro D, Ahrens K. 2012. Early exposure to probiotics in a canine model of atopic dermatitis has long-term clinical and immunological effects. Vet. Immunol. Immunopathol. 146: 185-118.

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Olivry T, Marsella R, Iwasaki T, Mueller R. 2007. International Task Force on Canine Atopic Dermatitis. Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis. Vet. Dermatol. 18: 78-86.

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A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis 원문보기

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A Double-Blind, Placebo Controlled-Trial of a Probiotic Strain Lactobacillus sakei Probio-65 for the Prevention of Canine Atopic Dermatitis 원문보기

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