[논문]족삼리의 선모(仙茅)약침이 Monosodium Iodoacetate로 유발한 골관절염 흰쥐에 미치는 영향

지민정; 임성철; 김재수; 이현종; 이윤규

doi:10.13045/acupunct.2015005

[국내논문] 족삼리의 선모(仙茅)약침이 Monosodium Iodoacetate로 유발한 골관절염 흰쥐에 미치는 영향
Effects of Curculiginis Rhizoma Pharmaco-Acupuncture at $ST_{36}$ on Monosodium Iodoacetate(MIA)-induced Osteoarthritic Rats 원문보기

The acupuncture = 대한침구의학회지, v.32 no.1, 2015년, pp.53 - 66

지민정 (대구한의대학교 한의과대학 침구경혈학교실) , 임성철 (대구한의대학교 한의과대학 침구경혈학교실) , 김재수 (대구한의대학교 한의과대학 침구경혈학교실) , 이현종 (대구한의대학교 한의과대학 침구경혈학교실) , 이윤규 (대구한의대학교 한의과대학 침구경혈학교실)

Abstract ▼ AI-Helper

Objectives : This study was designed to investigate effects of Curculiginis Rhizoma pharmaco-acupuncture at $ST_{36}$ on monosodium iodoacetate-induced osteoarthritic rats. Methods : Twenty rats were divided into four groups consisting of 5 rats: rats receiving no injection(normal), rats injected with monosodium Iodoacetate(MIA, control), rats injected with MIA and normal saline(N-S), and rats injected with MIA and Curculiginis Rhizoma (CRPA). N-S and CRPA were administered once a day at $ST_{36}$ during 21 days. After that we examined the weight-bearing ability of hind paws, liver and kidney function, immunocell, cytokines, proteins, and gene expression of cytokines. Injury of synovial tissue was measured by H & E, Safranin O immunofluorescence. Results : The weight-bearing ability of the hind paws, Serum TNF-${\alpha}$, IL-$1{\beta}$, IL-6, PGE2, LTB4, DPD, Osteocalcin, Protein COX-2 of CRPA decreased significantly. Protein Arachidonate 5 lipoxygenase of CRPA was decreased, but not significantly. Expression of gene COX-2, TNF-${\alpha}$, IL-$1{\beta}$, IL-6, NOS2 of CRPA decreased. In histological observations, CRPA was improved, compared with other control groups. Conclusions : It can be suggested that Curculiginis Rhizoma pharmaco-acupuncture at $ST_{36}$ has anti-inflammatory and pain relief effects on monosodium iodoacetate-induced osteoarthritic rats.

Keyword

질의응답

핵심어	질문	논문에서 추출한 답변
	족삼리의 仙茅약침이 골관절염에 미치는 영향을 살펴본 본 연구의 결론은 무엇인가?	1. 체중 변화는 각 군 간에 유의성이 없었다. 2. 뒷다리에 체중을 부하하는 정도가 유의성 있게 증가하였다. 3. AST, creatinine은 유의성 있게 감소하였고, ALT는 유의성이 없었다. 4. 혈청 내 TNF-α, IL-1β, IL-6, PGE2, LTB4, DPD, Osteocalcin은 유의성 있게 감소하였다. 5. COX-2 단백질은 유의성 있게 감소하였다. Arachidonate 5 lipoxygenase 단백질은 감소의 경향을 나타냈으나 유의성은 없었다. 6. COX-2, TNF-α, IL-1β, IL-6, NOS2의 유전자 발현은 감소하였다. 7. 병리조직학적 소견에서 활막의 손상 정도가 감소하였고 proteoglycan의 생성은 증가하였다.
	골관절염이란 무엇인가?	골관절염은 성인에서 가장 흔한 관절 질환의 하나로 퇴행성 관절염 또는 퇴행성 관절질환이라고 하며, 국소적인 관절에 대하여 점진적인 관절연골의 소실과 그와 관련된 이차적인 변화와 증상을 동반하는 질환을 의미한다.
	골관절염이 주로 발생하는 부위는 무엇인가?	골관절염은 주로 체중이 부하되는 관절에 많이 침범하며 관절연골의 국소적인 퇴행성 변화 및 연골하골의 비대, 주변 골연골부의 과잉 골형성, 관절의 변형 등을 그 특징으로 한다. 염증변화는 소수에서 나타나고 임상적으로는 반복적인 통증 및 관절 강직감, 점진적인 운동장애 등을 초래한다1,2).

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