$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Androgen Receptor-dependent Expression of Low-density Lipoprotein Receptor-related Protein 6 is Necessary for Prostate Cancer Cell Proliferation 원문보기

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, v.19 no.3, 2015년, pp.235 - 240  

Park, Eun (Department of Urology, Wallace Memorial Baptist Hospital) ,  Kim, Eun Kyoung (MRC for Ischemic Tissue Regeneration, Medical Research Institute, and Department of Pharmacology, Pusan National University School of Medicine) ,  Kim, Minkyoung (MRC for Ischemic Tissue Regeneration, Medical Research Institute, and Department of Pharmacology, Pusan National University School of Medicine) ,  Ha, Jung Min (MRC for Ischemic Tissue Regeneration, Medical Research Institute, and Department of Pharmacology, Pusan National University School of Medicine) ,  Kim, Young Whan (MRC for Ischemic Tissue Regeneration, Medical Research Institute, and Department of Pharmacology, Pusan National University School of Medicine) ,  Jin, Seo Yeon (MRC for Ischemic Tissue Regeneration, Medical Research Institute, and Department of Pharmacology, Pusan National University School of Medicine) ,  Shin, Hwa Kyoung (Department of Anatomy, Pusan National University School of Korean Medicine) ,  Ha, Hong Koo (Department of Urology, Pusan National University Hospital) ,  Lee, Jeong Zoo (Department of Urology, Pusan National University Hospital) ,  Bae, Sun Sik (MRC for Ischemic Ti)

Abstract ▼ AI-Helper 아이콘AI-Helper

Androgen receptor (AR) signaling is important for prostate cancer (PCa) cell proliferation. Here, we showed that proliferation of hormone-sensitive prostate cancer cells such as LNCaP was significantly enhanced by testosterone stimulation whereas hormone-insensitive prostate cancer cells such as PC3...

주제어

#Androgen receptor   #LRP6   #Prostate cancer   #Testosterone   #Wnt  

AI 본문요약
AI-Helper 아이콘 AI-Helper

* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.

대상 데이터

  • Target sequences were 5'-cgcgactactacaactttcca-3' (for AR) and 5'-ggctcaaccgtgaagttatag-3' (for LRP6).

데이터처리

  • When comparing two groups, an unpaired Student’s t-test was used to assess differences.

이론/모형

  • Data are analyzed by 2-ΔΔCT method.
본문요약 정보가 도움이 되었나요?

참고문헌 (31)

  1. 1 Jemal A Bray F Center MM Ferlay J Ward E Forman D Global cancer statistics CA Cancer J Clin 2011 61 69 90 21296855 

  2. 2 Eisenberger MA Blumenstein BA Crawford ED Miller G McLeod DG Loehrer PJ Wilding G Sears K Culkin DJ Thompson IM Jr Bueschen AJ Lowe BA Bilateral orchiectomy with or without flutamide for metastatic prostate cancer N Engl J Med 1998 339 1036 1042 9761805 

    상세보기

  3. 3 Tannock IF de Wit R Berry WR Horti J Pluzanska A Chi KN Oudard S Theodore C James ND Turesson I Rosenthal MA Eisenberger MA TAX 327 Investigators Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer N Engl J Med 2004 351 1502 1512 15470213 

    상세보기

  4. 4 Martinez HD Hsiao JJ Jasavala RJ Hinkson IV Eng JK Wright ME Androgen-sensitive microsomal signaling networks coupled to the proliferation and differentiation of human prostate cancer cells Genes Cancer 2011 2 956 978 22701762 

    상세보기

  5. 5 Wang Y Mikhailova M Bose S Pan CX deVere White RW Ghosh PM Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival Oncogene 2008 27 7106 7117 18776922 

    상세보기

  6. 6 Claessens F Verrijdt G Schoenmakers E Haelens A Peeters B Verhoeven G Rombauts W Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation J Steroid Biochem Mol Biol 2001 76 23 30 11384860 

  7. 7 Bolton EC So AY Chaivorapol C Haqq CM Li H Yamamoto KR Cell- and gene-specific regulation of primary target genes by the androgen receptor Genes Dev 2007 21 2005 2017 17699749 

    상세보기

  8. 8 DePrimo SE Diehn M Nelson JB Reiter RE Matese J Fero M Tibshirani R Brown PO Brooks JD Transcriptional programs activated by exposure of human prostate cancer cells to androgen Genome Biol 2002 3 RESEARCH0032 12184806 

  9. 9 Anastas JN Moon RT WNT signalling pathways as therapeutic targets in cancer Nat Rev Cancer 2013 13 11 26 23258168 

    상세보기

  10. 10 Huang H He X Wnt/beta-catenin signaling: new (and old) players and new insights Curr Opin Cell Biol 2008 20 119 125 18339531 

  11. 11 Wu G Huang H Garcia Abreu J He X Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6 PLoS One 2009 4 e4926 19293931 

  12. 12 Chen G Shukeir N Potti A Sircar K Aprikian A Goltzman D Rabbani SA Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications Cancer 2004 101 1345 1356 15316903 

  13. 13 Yu X Wang Y DeGraff DJ Wills ML Matusik RJ Wnt/β-catenin activation promotes prostate tumor progression in a mouse model Oncogene 2011 30 1868 1879 21151173 

  14. 14 Bruxvoort KJ Charbonneau HM Giambernardi TA Goolsby JC Qian CN Zylstra CR Robinson DR Roy-Burman P Shaw AK Buckner-Berghuis BD Sigler RE Resau JH Sullivan R Bushman W Williams BO Inactivation of Apc in the mouse prostate causes prostate carcinoma Cancer Res 2007 67 2490 2496 17363566 

    상세보기

  15. 15 Valkenburg KC Graveel CR Zylstra-Diegel CR Zhong Z Williams BO Wnt/β-catenin signaling in normal and cancer stem cells Cancers (Basel) 2011 3 2050 2079 24212796 

  16. 16 Kim EK Yun SJ Ha JM Kim YW Jin IH Yun J Shin HK Song SH Kim JH Lee JS Kim CD Bae SS Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis Oncogene 2011 30 2954 2963 21339740 

    상세보기

  17. 17 Smaletz O Scher HI Outcome predictions for patients with metastatic prostate cancer Semin Urol Oncol 2002 20 155 163 12012302 

    상세보기

  18. 18 Brown RS Edwards J Dogan A Payne H Harland SJ Bartlett JM Masters JR Amplification of the androgen receptor gene in bone metastases from hormone-refractory prostate cancer J Pathol 2002 198 237 244 12237884 

    상세보기

  19. 19 Bubendorf L Kononen J Koivisto P Schraml P Moch H Gasser TC Willi N Mihatsch MJ Sauter G Kallioniemi OP Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays Cancer Res 1999 59 803 806 10029066 

    상세보기

  20. 20 Edwards J Krishna NS Grigor KM Bartlett JM Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer Br J Cancer 2003 89 552 556 12888829 

    상세보기

  21. 21 Taylor BS Schultz N Hieronymus H Gopalan A Xiao Y Carver BS Arora VK Kaushik P Cerami E Reva B Antipin Y Mitsiades N Landers T Dolgalev I Major JE Wilson M Socci ND Lash AE Heguy A Eastham JA Scher HI Reuter VE Scardino PT Sander C Sawyers CL Gerald WL Integrative genomic profiling of human prostate cancer Cancer Cell 2010 18 11 22 20579941 

    상세보기

  22. 22 Tran C Ouk S Clegg NJ Chen Y Watson PA Arora V Wongvipat J Smith-Jones PM Yoo D Kwon A Wasielewska T Welsbie D Chen CD Higano CS Beer TM Hung DT Scher HI Jung ME Sawyers CL Development of a second-generation antiandrogen for treatment of advanced prostate cancer Science 2009 324 787 790 19359544 

    상세보기

  23. 23 Fenton MA Shuster TD Fertig AM Taplin ME Kolvenbag G Bubley GJ Balk SP Functional characterization of mutant androgen receptors from androgen-independent prostate cancer Clin Cancer Res 1997 3 1383 1388 9815822 

    상세보기

  24. 24 Taplin ME Rajeshkumar B Halabi S Werner CP Woda BA Picus J Stadler W Hayes DF Kantoff PW Vogelzang NJ Small EJ Cancer and Leukemia Group B Study 9663 Androgen receptor mutations in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663 J Clin Oncol 2003 21 2673 2678 12860943 

    상세보기

  25. 25 Culig Z Hoffmann J Erdel M Eder IE Hobisch A Hittmair A Bartsch G Utermann G Schneider MR Parczyk K Klocker H Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system Br J Cancer 1999 81 242 251 10496349 

  26. 26 Kelly WK Scher HI Prostate specific antigen decline after antiandrogen withdrawal: the flutamide withdrawal syndrome J Urol 1993 149 607 609 7679759 

    상세보기

  27. 27 Chesire DR Ewing CM Gage WR Isaacs WB In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis Oncogene 2002 21 2679 2694 11965541 

  28. 28 de la Taille A Rubin MA Chen MW Vacherot F de Medina SG Burchardt M Buttyan R Chopin D Beta-catenin-related anomalies in apoptosis-resistant and hormone-refractory prostate cancer cells Clin Cancer Res 2003 9 1801 1807 12738737 

    상세보기

  29. 29 Yang F Li X Sharma M Sasaki CY Longo DL Lim B Sun Z Linking beta-catenin to androgen-signaling pathway J Biol Chem 2002 277 11336 11344 11792709 

  30. 30 Koh SS Li H Lee YH Widelitz RB Chuong CM Stallcup MR Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators J Biol Chem 2002 277 26031 26035 11983685 

  31. 31 Song LN Gelmann EP Interaction of beta-catenin and TIF2/GRIP1 in transcriptional activation by the androgen receptor J Biol Chem 2005 280 37853 37867 16141201 

저자의 다른 논문 :

LOADING...

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로