In this study, the clinical safety and toxicology of oral ingestion of supplement capsules containing ginseng radix was investigated in healthy young volunteers. This study was a pilot randomized, double blinded, placebo controlled trial. The healthy volunteers were divided into 6 groups of 20 each ...
In this study, the clinical safety and toxicology of oral ingestion of supplement capsules containing ginseng radix was investigated in healthy young volunteers. This study was a pilot randomized, double blinded, placebo controlled trial. The healthy volunteers were divided into 6 groups of 20 each (10 males and 10 females). They took the ginseng powder for 35 days (3g/day) for safety evaluation. There were measured general healthy levels such as hematological, biochemical and electrocardiographic parameters. After the first week, besides Korean white ginseng the other treatments led to an significant increase of white blood cells. Korean red ginseng increased UREA (blood urea nitrogen) in healthy volunteers, but it didn't exceed the range of normal values, and in the subsequent process of treatment there is no effect of elevating UREA. After the three weeks, Korean white ginseng showed relatively low the content of blood glucose and low-density lipoprotein cholesterol. After the five weeks, compared with the other treatments, Korean red ginseng increased white blood cells, platelet distribution width and average volume of platelet. Korean white ginseng decreased low-density lipoprotein cholesterol. American ginseng decreased blood creatinine in healthy volunteers. In conclusion, through test the blood routine, urine routine, liver function, renal function, blood glucose, blood lipid and electrocardiogram, the healthy volunteers continuous taking ginseng for 35 days (3 g/day) is safe and reliable, and have no obvious adverse reactions and side effects.
In this study, the clinical safety and toxicology of oral ingestion of supplement capsules containing ginseng radix was investigated in healthy young volunteers. This study was a pilot randomized, double blinded, placebo controlled trial. The healthy volunteers were divided into 6 groups of 20 each (10 males and 10 females). They took the ginseng powder for 35 days (3g/day) for safety evaluation. There were measured general healthy levels such as hematological, biochemical and electrocardiographic parameters. After the first week, besides Korean white ginseng the other treatments led to an significant increase of white blood cells. Korean red ginseng increased UREA (blood urea nitrogen) in healthy volunteers, but it didn't exceed the range of normal values, and in the subsequent process of treatment there is no effect of elevating UREA. After the three weeks, Korean white ginseng showed relatively low the content of blood glucose and low-density lipoprotein cholesterol. After the five weeks, compared with the other treatments, Korean red ginseng increased white blood cells, platelet distribution width and average volume of platelet. Korean white ginseng decreased low-density lipoprotein cholesterol. American ginseng decreased blood creatinine in healthy volunteers. In conclusion, through test the blood routine, urine routine, liver function, renal function, blood glucose, blood lipid and electrocardiogram, the healthy volunteers continuous taking ginseng for 35 days (3 g/day) is safe and reliable, and have no obvious adverse reactions and side effects.
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문제 정의
We conducted collaboration research to resolve this issue with Jilin Agricultural University of China. The aim of this study was to evaluate the safety and toxicology of ginseng radix (P. ginseng, P. quinquefolium) delivered in capsule format in a randomized, double-blind, placebocontrolled study of closely monitored human subjects. The subject of experiment was Chinese young people.
제안 방법
However, these alterations were in normal ranges and they were not important clinically. Above this, we examined many items during the trial period, which are total cholesterol, triglyceride, high density lipoprotein cholesterol, direct bilirubin, total bilirubin, mean corpuscular hemoglobin, mean corpuscular, red cell distribution width standard deviation, alkaline phosphatase, gamma-glutamyl transpeptidase and carbon dioxide combining power, and there was no significant difference between the treatments (It was not given the data.). All the result of this study prove the food safety of Korean ginseng.
It was referred to the data of Korea, China, Japan and USA (Ji and Lee, 1987; Nam and Park, 2000). The study outcome measures were also evaluated at the end of 1 week, 3 weeks and 5 weeks of treatment. All participants provided written informed consent prior to the start of the study.
The study was a double-blind, placebo-controlled study consisting of 5 weeks intervention. 120 healthy young volunteers of China (age range 21~25 years) were selected for this study.
대상 데이터
The study was a double-blind, placebo-controlled study consisting of 5 weeks intervention. 120 healthy young volunteers of China (age range 21~25 years) were selected for this study. Before treatment, pulse rate and blood pressure readings were also taken, and a blood sample was taken for clinical examination and laboratory (hematology and blood biochemistry) investigations as well as urine analysis and electrocardiogram.
4 years of Chinese white ginseng (P. ginseng, produced in China), 6 years of Chinese red ginseng (P. ginseng, produced in China) and 4 years of American ginseng (P. quinquefolium) were purchased from Ji’an city of Jilin Province.
quinquefolium) delivered in capsule format in a randomized, double-blind, placebocontrolled study of closely monitored human subjects. The subject of experiment was Chinese young people. The safety of Korean ginseng for them will contribute to consumer layer and demand expand of Korean ginseng in China.
Volunteers were divided into 6 groups of 20 each (10 males and 10 females). Groups 1 received 3 g 4 years of Chinese white ginseng capsules, group 2 received 3 g 6 years of Chinese red ginseng capsules, group 3 received 3 g 4 years of Korean white ginseng capsules, group 4 received 3 g 6 years of Korean red ginseng capsules, group 5 received 3 g 4 years of American white ginseng capsules, group 6 received placebo (starch flour 3g), respectively, for 35 days.
데이터처리
Statistical analysis was done using Student’s paired t-test with SPSS software.
성능/효과
A once daily dose of different ginseng radix in capsule format taken over 5 weeks was used to demonstrate safety and toxicology in healthy young volunteers. In conclusion, through test the blood routine, urine routine, liver function, renal function, blood glucose, blood lipid and electrocardiogram, indicated that healthy volunteers continuous taking ginseng for 35 days (3 g/day) is safe and reliable, and have no obvious adverse reactions and side effects. This study also showed that ginseng radix may change some hematological and biochemical parameters.
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