최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기생명과학회지 = Journal of life science, v.25 no.6 = no.182, 2015년, pp.693 - 702
김억천 (연세대학교 생명과학기술학부) , 김서호 (연세대학교 생명과학기술학부) , 배기호 (연세대학교 생명과학기술학부) , 김한성 (연세대학교 의공학과) , 겔린스키 미첼 (드레스덴 공대 의과대학 병원) , 김택중 (연세대학교 생명과학기술학부)
Blocking new blood-vessel formation (angiogenesis) is now recognized as a useful approach to the therapeutic treatment of many solid tumors. The best validated approach to date is to target the vascular endothelial growth-factor (VEGF) pathway, a key regulator of angiogenesis. Many natural products ...
* AI 자동 식별 결과로 적합하지 않은 문장이 있을 수 있으니, 이용에 유의하시기 바랍니다.
Balbay, M. D., Pettaway, C. A., Kuniyasu, H., Inoue, K., Ramirez, E., Li, E., Fidler, I. J. and Dinney, C. P. 1999. Highly metastatic human prostate cancer growing withinthe prostate of athymic mice overexpresses vascular endothelial growth factor. Clin. Cancer Res. 5, 783-789.
Brown, K. J., Maynes, S. F., Bezos, A., Maguire, D. J., Ford, M. D. and Parish, C. R. 1996. A novel in vitro assay for human angiogenesis. Lab. Invest. 75, 539-555.
Carmeliet, P. and Jain, R. K. 2000. Angiogenesis in cancer and other diseases. Nature 407, 249-257.
Chen, M. L., Lin, Y. H., Yang, C. M. and Hu, M. L. 2012. Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways. Mol. Nutr. Food Res. 56, 889-899.
Cho, Y. R., Kim, S. H., Ko, H. Y., Kim, M. D., Choi, S. W. and Seo, D. W. 2011. Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. Oncol. Rep. 26, 861-867.
Doyle, J. L. and Haas, T. L. 2009. Differential role of beta-catenin in VEGF and histamine-induced MMP-2 production in microvascular endothelial cells. J. Cell. Biochem. 107, 272-283.
Dvorak, H. F. 2002. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol. 20, 4368-4380.
Ferrara, N. 2009. Vascular endothelial growth factor. Arterioscler. Thromb. Vasc. Biol. 29, 789-791.
Ferrara, N. and Henzel, W. J. 1989. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161, 851-858.
Ferrara, N. 2001. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am. J. Physiol. Cell Physiol. 280, C1358-C1366.
Folkman, J. 1974. Proceedings: Tumor angiogenesis factor. Cancer Res. 34, 2109-2113.
Folkman, J. 1995. Clinical applications of research on angiogenesis. N. Engl. J. Med. 333, 1757-1763.
Fong, T. A., Shawver, L. K., Sun, L., Tang, C., App, H., Powell, T. J., Kim, Y. H., Schreck, R., Wang, X., Risau, W., Ullrich, A., Hirth, K. P. and McMahon, G. 1999. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 59, 99-106.
Galardy, R. E., Grobelny, D., Foellmer, H. G. and Femandez, L. A. 1994. Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R- 2 (hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide. Cancer Res. 54, 4715-4718.
Garcia, G. E., Nichole, A., Bhaskaran, S., Gupta, A., Kyprianou, N. and Kumar, A. P. 2006. Akt- and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract. Neoplasia 8, 523-533.
Ghosh, R., Graham, H., Rivas, P., Tan, X. J., Crosby, K., Bhaskaran, S., Schoolfield, J., Banu, J., Femandes, G., Yeh, I. T. and Kumar, A. P. 2010. Phellodendron amurense bark extract prevents progression of prostate tumors in transgenic adenocarcinoma of mouse prostate: potential for prostate cancer management. Anticancer Res. 30, 857-865.
Gong, J., Muñoz, A. R., Chan, D., Ghosh, R. and Kumar, A. P. 2014. STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth. Oncotarget 15, 2529-2541.
Gong, J., Xie, J., Bedolla, R., Rivas, P., Chakravarthy, D., Freeman, J. W., Reddick, R., Kopetz, S., Peterson, A., Wang, H., Fischer, S. M. and Kumar, A. P. 2014. Combined targeting of STAT3/NF-κB/COX-2/EP4 for effective managementof pancreatic cancer. Clin. Cancer Res. 20, 1259-1273.
Huang, S., Yang, N., Liu, Y., Hu, L., Zhao, J., Gao, J., Li, Y., Li, C., Zhang, X. and Huang, T. 2012. Grape seed proanthocyanidins inhibit angiogenesis via the downregulation of both vascular endothelial growth factor and angiopoietinsignaling. Nutr. Res. 32, 530-536.
James, M. A., Fu, H., Liu, Y., Chen, D. R. and You, M. 2011. Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. Mol. Carcinog. 50, 1-7.
Kerbel, R. S. 2008. Tumor angiogenesis. N. Engl. J. Med. 358, 2039-2049.
Kitamura, M., Toi, M., Arai, K., Iwasaki, Y., Suzuki, H. and Matsuo, K. 1998. Concentrations of vascular endothelial growth factor in the sera of gastric cancer patients. Oncol. Rep. 5, 1419-1424.
Kim, J. H., Huh, J. E., Baek, Y. H., Lee, J. D., Choi, D. Y. and Park, D. S. 2011. Effect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytes. J. Ethnopharmacol. 134, 234-242.
Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S. and Ferrara, N. 1993. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362, 841-844.
Kumar, A. P., Bhaskaran, S., Ganapathy, M., Crosby, K., Davis, M. D., Kochunov, P., Schoolfield, J., Yeh, I. T., Troyer, D. A. and Ghosh, R. 2007. Akt/cAMP-responsiveelement binding protein/cyclin D1 network: a novel target for prostate cancer inhibition in transgenic adenocarcinoma of mouse prostate model mediated by Nexrutine, a Phellodendron Amurense bark extract. Clin. Cancer Res. 13, 2784-2794.
Kumar, R., Das, M. and Ansari, K. M. 2012. Nexrutine(R) inhibits tumorigenesis in mouse skin and induces apoptotic cell death in human squamous carcinoma A431 and human melanoma A375 cells. Carcinogenesis 33, 1909-1918.
Kurebayashi, J., Otsuki, T., Kunisue, H., Mikami, Y., Tanaka, K., Yamamoto, S. and Sonoo, H. 1999. Expression of vascular endothelial growth factor (VEGF) family members in breast cancer. Jpn. J. Cancer Res. 90, 977-981.
Lee, S. J., Park, K., Ha, S. D., Kim, W. J. and Moon, S. K. 2010. Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M-phase cell cycle arrest and p53 expression. Phytother. Res. 24, 1870-1876.
Leu, C. H., Li, C. Y., Yao, X. and Wu, T. S. 2006. Constituents from the Leaves of Phellodendron amurense and Their Antioxidant Activity. Chem. Pharm. Bull. 54, 1308-1311.
Lirdprapamongkol, K., Mahidol, C., Thongnest, S., Prawat, H., Ruchirawat, S., Srisomsap, C., Surarit, R., Punyarit, P. and Svasti, J. 2003. Anti-metastatic effects of aqueous extract of Helixanthera parasitica. J. Ethnopharmacol. 86, 253-256.
Lord, S. and Harris, A. L. 2010. Angiogenesis-still a worthwhile target for breast cancer therapy?. Breast Cancer Res. 12 (Suppl. 4), S19.
Los, M., Roodhart, J. M. and Voest, E. E. 2007. Target practice: lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer. Oncologist 12, 443-450.
Mori, H., Fuchigami, M., Inoue, N., Nagai, H., Koda, A., Nishioka, I. and Meguro, K. 1995. Principle of the bark Phellodendron amurense to suppress the cellular immune response: effect of Phellodendron on cellular and humoral immune response. Planta. Med. 61, 45-49.
Moses, M. A. 1997. The regulation of neovascularization by matrix metalloproteinases and their inhibitors. Stem Cells 15, 180-189.
Muralimanoharan, S. B., Kunnumakkara, A. B., Shylesh, B., Kulkarni, K. H., Haiyan, X., Ming, H., Aggarwal, B. B., Rita, G. and Kumar, A. P. 2009. Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. Prostate 69, 494-504.
Nilsson, M. and Heymach, J. V. 2006. Vascular Endothelial Growth Factor (VEGF) pathway. J. Thorac. Oncol. 1, 768-770.
Oshikawa, J., Kim, S. J., Furuta, E., Caliceti, C., Chen, G. F., Mckinney, R. D., Kuhr, F., Levitan, I., Fukai, T. and Ushio-Fukai, M. 2012. Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 302, H724-H732.
Park, E. K., Rhee, H. I., Jung, H. S., Ju, S. M., Lee, Y. A., Lee, S. H., Hong, S. J., Yang, H. I., Yoo, M. C. and Kim, K. S. 2007. Antiinflammatory effects of a combined herbal preparation (RAH13) of Phellodendron amurense and Coptis chinensis in animal models of inflammation. Phytother. Res. 21, 746-750.
Peng, W. H., Wu, C. R., Chen, C. S., Chen, C. F., Leu, Z. C. and Hsieh, M. T. 2004. Anxiolytic effect of berberine on exploratory activity of the mouse in two experimental anxiety models: interaction with drugs acting at 5-HT receptors. Life Sci. 75, 2451-2462.
Prewett, M., Huber, J., Li, Y., Santiago, A., O’Connor, W., King, K., Overholser, J., Hooper, A., Pytowski, B., Witte, L., Bohlen, P. and Hicklin, D. J. 1999. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res. 59, 5209-5218.
Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N. and Shibuya, M. 2005. Essential role of flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc. Natl. Acad. Sci. USA 102, 1076-1081.
Senan, S. and Smit, E. F. 2007. Design of clinical trials of radiation combined with antiangiogenic therapy. Oncologist 12, 465-477.
Shaheen, R. M., Davis, D. W., Liu, W., Zebrowski, B. K., Wilson, M. R., Bucana, C. D., McConkey, D. J., McMahon, G. and Ellis, L. M. 1999. Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res. 59, 5412-5416.
Steven, B. 1999. Angiogenesis and cancer control. From concept to therapeutic trial. Cancer Control 5, 436-458.
Stratmann, J., Wang, C. J., Gnosa, S., Wallin, A., Hinselwood, D., Sun, X. F. and Zhang, H. 2011. Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients. BMC Cancer 11, 345.
Visse, R. and Nagase, H. 2003. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ. Res. 92, 827-839.
Xian, Y. F., Mao, Q. Q., Ip, S. P., Lin, Z. X. and Che, C. T. 2011. Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex PhellodendriAmurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice. J. Ethnopharmacol. 137, 1425-1430.
Xu, Y. and Ventura, S. 2010. Extracts of bark from the traditional Chinese herb Phellodendron amurense inhibit contractility of the isolated rat prostate gland. J. Ethnopharmacol. 127, 196-199.
Yi, J. M., Park, J. S., Oh, S. M., Lee, J., Kim, J., Oh, D. S., Bang, O. S. and Kim, N. S. 2012. Ethanol extract of Gleditsia sinensis thorn suppresses angiogenesis in vitro and in vivo. BMC Complement. Altern. Med. 12, 243-252.
Yoshiji, H., Kuriyama, S., Hicklin, D. J., Huber, J., Yoshii, J., Miyamoto, Y., Kawata, M., Ikenaka, Y., Nakatani, T., Tsujinoue, H. and Fukui, H. 1999. KDR/Flk-1 is a major regulator of vascular endothelial growth factorinduced tumor development and angiogenesis in murine hepatocellular carcinoma cells. Hepatology 30, 1179-1186.
Zhang, L., Ji, Q., Liu, X., Chen, X., Chen, Z., Qiu, Y., Sun, J., Cai, J., Zhu, H. and Li, Q. 2013. Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways. Cancer Sci. 104, 604-610.
Zhou, H. Y., Wang, D. and Cui, Z. 2008. Ferulates, amurenlactone A and amurenamide A from traditional Chinese medicine cortex Phellodendri Amurensis. J. Asian Nat. Prod. Res. 10, 409-413.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.