선택한 단어 수는 입니다.
최소 단어 이상 선택하여야 합니다.
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선택한 단어 수는 30입니다.
최대 10 단어까지만 선택 가능합니다.
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제안 방법
- In summary, the results of this study provided the first comparison of circulating metabolite profiles of rosiglitazone in rat after IP and PO administration. On the basis of metabolite profiling and the structures of metabolites, major metabolic pathways of rosiglitazone in rat appear to involve de-methylation (M5).
대상 데이터
- A group of six SD rats was housed individually in stainless steel cages. Among them, a single dose rosiglitazone was orally administered to three rats at a target dose level of 10 ㎎/㎏.
- HPLC grade acetonitrile (ACN) and HPLC grade water were purchased from Fisher Scientific (Fair Lawn, NJ, USA). Formic acid (minimum of 95%) was obtained from Sigma- Aldrich (St. Louis, MO, USA). All reagents were of analytical grade or better and were used prior to their respective expiration dates.
- Rosiglitazone (Fig. 1) was purchased from Sigma- Aldrich (St. Louis, MO, USA). HPLC grade acetonitrile (ACN) and HPLC grade water were purchased from Fisher Scientific (Fair Lawn, NJ, USA).
- SD rats (~250 g) were purchased from Samtako (Chungbuk, Korea). Animals were quarantined for a minimum of 7 days prior to treatment and maintained on a 12-h light/dark cycle.
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