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Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: exploration of a novel CYP2B6 phenotyping index 원문보기

British journal of clinical pharmacology, v.75 no.1, 2013년, pp.244 - 253  

Jiang, Fen (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) ,  Desta, Zeruesenay (Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA) ,  Shon, Ji‐Hong (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) ,  Yeo, Chang‐Woo (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) ,  Kim, Ho‐Sook (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) ,  Liu, Kwang‐Hyeon (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) ,  Bae, Soo‐Kyung (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) ,  Lee, Sang‐Seop (Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea) ,  Flockhart, David A. (Division of Clinical) ,  Shin, Jae‐Gook

Abstract AI-Helper 아이콘AI-Helper

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Cytochrome P450 (CYP) 2B6 is the enzyme primarily responsible for the metabolism of many clinically important drugs, including efavirenz, which it converts to 8‐hydroxyefavirenz and then to 8,14‐hydroxyefavirenz.• The CYP2B6*6...

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참고문헌 (33)

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