Diospyros burmanica Kurz. is an evergreen deciduous tree distributed in Mandalay of Myanmar, which belongs to the family of Ebenaceae. In Myanmar, it has been used to treat diarrhea, diabetes, diabetes and also as lumbers. In this study, seven flavonoids (1 - 7), a phenolic compound (8), and five tr...
Diospyros burmanica Kurz. is an evergreen deciduous tree distributed in Mandalay of Myanmar, which belongs to the family of Ebenaceae. In Myanmar, it has been used to treat diarrhea, diabetes, diabetes and also as lumbers. In this study, seven flavonoids (1 - 7), a phenolic compound (8), and five triterpenes (9 - 13) were isolated from the barks of D. burmanica and their chemical structures were elucidated. Isolates were identified to be (+)-catechin (1), (+)-catechin 3-O-$\alpha$-L-rhamnopyranoside (2), (+)-catechin 3-O-gallate (3), (-)-epicatechin (4), (-)-epicatechin 3-O-gallate (5), (+)-afzelechin 3-O-$\alpha$-L-rhamnopyranoside (6), (+)-2,3-trans-dihydrokaempferol 3-O-$\alpha$-L-rhamnopyranoside (7), methyl gallate (8), lupeol (9), methyl lup-20(29)-en-3-on-28-oate (10), $\beta$-amyrin (11), $\alpha$-amyrin (12), $3\beta$-hydroxy-D:B-friedo-olean-5-ene (13) through MS, 1H NMR and 13C NMR spectroscopic evidences.
Diospyros burmanica Kurz. is an evergreen deciduous tree distributed in Mandalay of Myanmar, which belongs to the family of Ebenaceae. In Myanmar, it has been used to treat diarrhea, diabetes, diabetes and also as lumbers. In this study, seven flavonoids (1 - 7), a phenolic compound (8), and five triterpenes (9 - 13) were isolated from the barks of D. burmanica and their chemical structures were elucidated. Isolates were identified to be (+)-catechin (1), (+)-catechin 3-O-$\alpha$-L-rhamnopyranoside (2), (+)-catechin 3-O-gallate (3), (-)-epicatechin (4), (-)-epicatechin 3-O-gallate (5), (+)-afzelechin 3-O-$\alpha$-L-rhamnopyranoside (6), (+)-2,3-trans-dihydrokaempferol 3-O-$\alpha$-L-rhamnopyranoside (7), methyl gallate (8), lupeol (9), methyl lup-20(29)-en-3-on-28-oate (10), $\beta$-amyrin (11), $\alpha$-amyrin (12), $3\beta$-hydroxy-D:B-friedo-olean-5-ene (13) through MS, 1H NMR and 13C NMR spectroscopic evidences.
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제안 방법
burmanica, only a paper has been reported revealing bisnaphtoquinones and naphthol derivatives and their leishmanicidal inhibitory activities.7This study focused on the further phytochemical investigation of D. burmanica and led to the isolation of seven flavonoids, a phenolic compound, and five triterpenes.
대상 데이터
A Gilson preparative HPLC system (Gilson, USA) was used to isolate compounds and equipped with a GX-271 liquid handler, binary pumps, and an UV/VIS- 155 detector. An MPLC system composed of an IOTA S 300 pump (ECOM, Czech Republic) and a Saphire 600 UV-VIS variable wavelength detector (ECOM, Czech Republic) were used. The preparative HPCCC (Dynamic Extractions, UK) possessed two sets of two bobbins.
Plant material−Barks and leaves of D. burmanica were collected from AKNP of Myanmar in February 2012, and identified by Professor Young-Dong Kim (Hallym University, Chuncheon, Korea). A voucher specimen (CU-2014-2-12) was deposited at the Herbarium of College of Pharmacy, The Catholic University of Korea.
6 Hz, H-12). The 13C NMR revealed thirty carbons containing two olefinic carbons at δC 121.9 (C-12), 145.4 (C-13) and an oxygenated carbon at δC 76.6 (C-3). On the basis of above spectroscopic data and comparing them with published values, compound 11 was identified to be β-amyrin.
참고문헌 (19)
Tangmouo, J. G.; Ho, R.; Lannang, A. M.; Komguem, J.; Lontsi, A.T.; Lontsi, D.; Hostettmann, K. Phytochem. Lett. 2009, 2, 192-195.
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da Silva, D. A.; Alves, V. G.; Franco, D. M.; Ribeiro, L. C.; de Souza, M. C.; Kato, L.; de Carvalho, J. E.; Kohn, L. K.; de Oliveira, C. M.; da Silva, C. C. Nat. Prod. Res. 2012, 26, 364-369.
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