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NTIS 바로가기Journal of applied biological chemistry, v.58 no.3, 2015년, pp.241 - 246
김재영 (Department of Herbal Cosmetic Science, Hoseo University) , 이용화 (Department of Herbal Cosmetic Science, Hoseo University) , 안현진 (Yeo Myung Biochem Co., Ltd.) , 이재덕 (Yeo Myung Biochem Co., Ltd.) , 이용섭 (Department of Herbal Cosmetic Science, Hoseo University)
This study was performed to investigate the antiinflammatory activities of taxifolin from Opuntia humifusa. A potent anti-oxidant activity was shown from the leaf extract at
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핵심어 | 질문 | 논문에서 추출한 답변 |
---|---|---|
염증반응이란? | 염증반응은 외부의 물리적, 화학적 자극, 세균에 의한 침윤작용에 대한 면역체계반응의 하나이며 손상을 수복, 재생하려는 기전이다(Zamora 등, 2000). 그러나 만성염증반응은 오히려 인간에게 질병을 일으키는 원인이 되기도 한다. | |
천년초 추출물에 함유된 플라보노이드 화합물은? | 천년초 추출물에서 특히 라디칼 소거능을 비롯한 강력한 항산화 활성과 더불어 항균 효과를 보여주었으며 taxifolin과 같은 플라보노이드 화합물이 분포하는 것으로 보고 되었다(Lee 등, 2000; Lee 등, 2005; Lee와 Lee, 2010). 특히 taxifolin의 항산화 효과가 α-tocopherol보다 우수하다고 보고 되었으며(Lee, 2004), 1,1-diphenyl-2-picrylhydrazyl (DPPH) 라디칼에 대한 소거활성 및 tyrosinase의 저해활성을 나타내어 화장품 첨가제로서의 가능성을 시사하였다(Lee 등, 2000). | |
nitric oxide이 과량 생성되면 어떤 물질로서 작용하는가? | 염증반응에 의하여 활성화된 대식세포에서는 염증반응 시 발생하는 nitric oxide (NO)와 tumor necrosis factor-α (TNF-α), inerleukin-6 (IL-6) 등의 cytokine을 생산하여 초기 염증반응의 중요한 역할을 한다. 하지만 과량 생성된 NO는 급성과민성염증반응을 유도하는 무기 자유라디칼 물질로서 작용한다(Salerno 등, 2002; Libby, 2006). 염증인자들은 염증성장질환을 일으키며 심지어 암과 같은 만성질환을 유발하기도 한다(Atreya 등, 2005). |
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