오가노겔은 반고형상이며 3차원의 네트워크 구조로 이루어진 친유성 용매로 이루어져 있다. 본 연구에서는 유상과 수상에서 모두 난용성 특징을 가진 제니스테인을 포함하는 레시틴 오가노겔을 개발하였다. 이 시스템은 안정할 뿐만 아니라 경피 흡수 실험에서도 높은 흡수율을 보였다. 본 오가노겔 제형에 적합한 원료들을 선별한 결과, 수화된 레시틴, 해바라기유, dipropylene glycol (DPG), polyethylene glycol (PEG)이 이 시스템에서 주로 사용되었다. 레시틴 오가노겔의 제조에 적합한 원료의 함량은 phase ternary diagram 작성을 통하여 결정하였다. 제조된 레시틴 오가노겔을 organoleptic characteristics, stability, pH, rheology, phase transition temperatures, microscopic analysis, skin penetration 실험을 통해 평가하였다. 본 연구 결과를 통해 본 논문에서 제시하는 레시틴 오가노겔 제형은 안정한 상태에서 난용성 물질을 높은 농도로 피부에 효과적으로 전달할 수 있는 제형으로 활용될 수 있을 것이라 생각된다.
오가노겔은 반고형상이며 3차원의 네트워크 구조로 이루어진 친유성 용매로 이루어져 있다. 본 연구에서는 유상과 수상에서 모두 난용성 특징을 가진 제니스테인을 포함하는 레시틴 오가노겔을 개발하였다. 이 시스템은 안정할 뿐만 아니라 경피 흡수 실험에서도 높은 흡수율을 보였다. 본 오가노겔 제형에 적합한 원료들을 선별한 결과, 수화된 레시틴, 해바라기유, dipropylene glycol (DPG), polyethylene glycol (PEG)이 이 시스템에서 주로 사용되었다. 레시틴 오가노겔의 제조에 적합한 원료의 함량은 phase ternary diagram 작성을 통하여 결정하였다. 제조된 레시틴 오가노겔을 organoleptic characteristics, stability, pH, rheology, phase transition temperatures, microscopic analysis, skin penetration 실험을 통해 평가하였다. 본 연구 결과를 통해 본 논문에서 제시하는 레시틴 오가노겔 제형은 안정한 상태에서 난용성 물질을 높은 농도로 피부에 효과적으로 전달할 수 있는 제형으로 활용될 수 있을 것이라 생각된다.
Organogels are semi-solid systems that consist of an apolar solvent as the liquid phase within a three-dimensional networked structure. In this study, we developed a stable and skin penetration-enhanced Lecithin Organogel (LO) containing genistein, which is one of the poorly soluble active ingredien...
Organogels are semi-solid systems that consist of an apolar solvent as the liquid phase within a three-dimensional networked structure. In this study, we developed a stable and skin penetration-enhanced Lecithin Organogel (LO) containing genistein, which is one of the poorly soluble active ingredients in both polar and apolar phase. After screening of various components (type of gelators, organic and aqueous phase), hydrogenated lecithin (HL), sunflower oil (SO), dipropylene glycol (DPG), and polyethylene glycol (PEG) were mainly used in this formulation. Phase ternary diagram was employed for optimization of the composition in the LO. The formulated LO were evaluated for its organoleptic characteristics, stability, pH, rheology, phase transition temperatures, microscopic analysis and skin penetration. The optimized stable LO system can be utilized as an effective and stable cosmetic formulation that can carry poorly soluble active ingredients at high concentration for topical dermal delivery.
Organogels are semi-solid systems that consist of an apolar solvent as the liquid phase within a three-dimensional networked structure. In this study, we developed a stable and skin penetration-enhanced Lecithin Organogel (LO) containing genistein, which is one of the poorly soluble active ingredients in both polar and apolar phase. After screening of various components (type of gelators, organic and aqueous phase), hydrogenated lecithin (HL), sunflower oil (SO), dipropylene glycol (DPG), and polyethylene glycol (PEG) were mainly used in this formulation. Phase ternary diagram was employed for optimization of the composition in the LO. The formulated LO were evaluated for its organoleptic characteristics, stability, pH, rheology, phase transition temperatures, microscopic analysis and skin penetration. The optimized stable LO system can be utilized as an effective and stable cosmetic formulation that can carry poorly soluble active ingredients at high concentration for topical dermal delivery.
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제안 방법
To formulate the LO, investigation of proper ingredients was performed, first. To make a normal LO, unhydrogenated lecithin has been used for an organogelator[28,29], and it has been known that when synthetic lecithins containing residues of saturated fatty acids are examined, the organogel is not formed[29].
대상 데이터
Several kinds of oils, lecithins and polyols were examined and HL (> 94% phosphatidylcholine), SO, DPG and PEG-8 were selected.
Hydrogenated lecithin (HL) (Emulmetik 950) was purchased from LucasMeyer (France). Sunflower oil (SO) (high oleic sunflower oil deodorized), polyethylene (Perfomalene 400), PEG-8 (PEG-400), and dipropylene glycol (DPG) (DPG-FC) were purchased at Aldivia (France), New Phase Technologies (USA), Surfachem (England), and SKC Inc. (USA), respectively. Genistein was purchased at Xi’an natural field bio-technique (China).
The amount of genistein in the receiving media and skin was determined by high-performance liquid chromatography (HPLC). The HPLC system consisted of 1260 series pump, and UV/visible detector all from Agilent (USA). UV/visible detector was set at 260 nm.
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