[논문]Attenuating effect of Lactobacillus brevis G101 on the MSG symptom complex in a double-blind, placebo-controlled study

Kim, Dong-Hyun; Choi, Yeji; Park, Sun-Sung; Kim, Se-Young; Han, Myung Joo

doi:10.4162/nrp.2015.9.6.673

Abstract ▼ AI-Helper

BACKGROUND/OBJECTIVES: Lactobacillus brevis G101 suppresses the absorption of monosodium glutamate (MSG) from the intestine into the blood in mice. Therefore, the attenuating effect of orally administered G101 on monosodium glutamate (MSG) symptom complex was investigated in humans MATERIALS/METHODS...

BACKGROUND/OBJECTIVES: Lactobacillus brevis G101 suppresses the absorption of monosodium glutamate (MSG) from the intestine into the blood in mice. Therefore, the attenuating effect of orally administered G101 on monosodium glutamate (MSG) symptom complex was investigated in humans MATERIALS/METHODS: Capsules (300 mg) containing Lactobacillus brevis G101 ($1{\times}10^{10}CFU/individual$) or maltodextrin (placebo) was orally administered in 30 respondents with self-recognized monosodium glutamate (MSG) symptom complex for 5 days and the rice with black soybean sauce containing 6 g MSG (RBSM) was ingested 30 min after the final administration. Thereafter, the MSG symptom complex (rated on a 5-point scale: 1, none; 5, strong) was investigated in a double blind placebo controlled study. The intensity of the MSG symptom complex was significantly reduced in respondents of the G101 intake group ($2.87{\pm}0.73$) compared to that in those treated with the placebo ($3.63{\pm}1.03$) (P = 0.0016). Respondents in the placebo group exhibited more of the various major conditions of the MSG symptom complex than in the G101 intake group. Although there was no significant difference in the appearance time of the MSG symptom complex between subjects orally administered G101 and those administered the placebo, its disappearance in < 3 h was observed in 69.9% of subjects in the G101 treatment group and in 38.0% of subjects in the placebo group (P = 0.0841). CONCLUSIONS: Oral administration of Lactobacillus brevis G101 may be able to reduce the intensity of the MSG symptom complex.

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가설 설정

1) RBSM is the rice with black soybean sauce containing 6 g MSG.

제안 방법

The subjects were evenly divided into 2 groups (A and B). In the first week, group A subjects were orally administered one capsule (Lactobacillus brevis G101) at 11:00 am for 5 days and group B subjects took the placebo capsule every day (Table 1). RBSM was ingested 30 min after the final administration of G101, and the intensity and variety of the MSG symptom complex over 6 h were described.
In the present study, to investigate the ability of orally administered Lactobacillus brevis G101 to attenuate the MSG symptom complex, we orally administered G101 or a placebo (maltodextrin) to respondents presenting with self-recognized MSG symptom complex, following ingestion of rice with black soybean sauce (Jajangbap) containing 6 g MSG (RBSM), and then investigated the intensity of the MSG complex in them. This experiment was performed as a double-blind, placebocontrolled study.
To evaluate the attenuating effect of Lactobacillus brevis G101 against the MSG symptom complex, we orally administered G101 to volunteers who then ingested RBSM, and after which we evaluated the MSG symptom complex for 6 h in a doubleblind, placebo-controlled study (Table 2). The intensity of MSG symptom complex was measured using a 5-point scale (1 = none, 5 = strong).

대상 데이터

All 30 subjects participated in an orientation session for this study. The subjects were evenly divided into 2 groups (A and B).
RBSM was prepared by mixing steamed rice (180 g) and MSG-contained black soybean sauce. The ingredients of the MSG-contained black soybean sauce (one serving) were as follows: 40 g pork, 40 g onion, 40 g zucchini, 30 g carrot, 50 g cabbage, 1 Tsp black soybean sauce without MSG, 1/2 Tsp soybean oil, 6 g MSG, 1 tsp starch, and 1 2/3 Tsp water. MSG was purchased from a local market.
The study subjects consisted of 30 healthy Korean individuals (average age, 23.57 ± 2.36 yrs; 10 male subjects, 23.00 ± 3.46 yrs; 20 female subjects, 23.85 ± 1.60 yrs) who self-identified as MSG-sensitive.

이론/모형

To evaluate the attenuating effect of Lactobacillus brevis G101 against the MSG symptom complex, we orally administered G101 to volunteers who then ingested RBSM, and after which we evaluated the MSG symptom complex for 6 h in a doubleblind, placebo-controlled study (Table 2). The intensity of MSG symptom complex was measured using a 5-point scale (1 = none, 5 = strong). Oral administration of G101 significantly attenuated the intensity of the MSG symptom complex (P =0.

성능/효과

1) MSG symptom complex was evaluated as follows: 1 = none, 2 = slight, 3= moderate, 4-slightly storong, and 5 = strong.
In conclusion, this study suggests that orally administration of Lactobacillus brevis G101 may be able to reduce the intensity of the MSG symptom complex and shorten its disappearance time.
5 to 12 g, and increased intensity of the MSG symptom response was related to an increase in the oral dose [15]. In this study, we found that oral administration of RBSM, which is containing 6 g of MSG, showed various side effects including thirstiness (56.7%), drowsiness (23.3%), weakness (6.7%), indigestion (6.7%), headache (3.3%), and nausea (3.3%). It was previously shown that the elimination of all food sources containing MSG resulted in a decreased frequency of headaches [3].
7%). No significant difference was observed between the varieties of self-recognized symptoms experienced by respondents who were orally administered G101 and those administered the placebo.

참고문헌 (15)

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8 Kanmani P Satish Kumar R Yuvaraj N Paari KA Pattukumar V Arul V Probiotics and its functionally valuable products-a review Crit Rev Food Sci Nutr 2013 53 641 658 23627505

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9 Gomes AM Malcata FX Bifidobacterium spp. and Lactobacillus acidophilus: biological, biochemical, technological and therapeutical properties relevant for use as probiotics Trends Food Sci Technol 1999 10 139 157

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10 Cho YR Chang JY Chang HC Production of gamma-aminobutyric acid (GABA) by Lactobacillus buchneri isolated from kimchi and its neuroprotective effect on neuronal cells J Microbiol Biotechnol 2007 17 104 109 18051360

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11 Tamura T Noda M Ozaki M Maruyama M Matoba Y Kumagai T Sugiyama M Establishment of an efficient fermentation system of gamma-aminobutyric acid by a lactic acid bacterium, Enterococcus avium G-15, isolated from carrot leaves Biol Pharm Bull 2010 33 1673 1679 20930374

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12 Cherubini E Gaiarsa JL Ben-Ari Y GABA: an excitatory transmitter in early postnatal life Trends Neurosci 1991 14 515 519 1726341

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13 Jang SE Han MJ Kim SY Kim DH Lactobacillus brevis G101 inhibits the absorption of monosodium glutamate in mice J Microbiol Biotechnol 2014 24 1592 1596 25394513

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14 Jang SE Hyam SR Han MJ Kim SY Lee BG Kim DH Lactobacillus brevis G-101 ameliorates colitis in mice by inhibiting NF-κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages J Appl Microbiol 2013 115 888 896 23742179

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15 Schaumburg HH Byck R Gerstl R Mashman JH Monosodium L-glutamate: its pharmacology and role in the Chinese restaurant syndrome Science 1969 163 826 828 5764480

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Attenuating effect of Lactobacillus brevis G101 on the MSG symptom complex in a double-blind, placebo-controlled study 원문보기

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