[논문]Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease

Kim, Kyu-Tae; Park, Hee-Myung; Hyun, Changbaig; Seo, Kyoung-Won; Song, Kun-Ho

doi:10.14405/kjvr.2016.56.4.205

Serum serotonin concentration in lean and obese dogs with myxomatous mitral valve disease 원문보기

Korean journal of veterinary research = 대한수의학회지, v.56 no.4, 2016년, pp.205 - 208

Kim, Kyu-Tae (College of Veterinary Medicine, Chungnam National University) , Park, Hee-Myung (College of Veterinary Medicine, Konkuk University) , Hyun, Changbaig (College of Veterinary Medicine, Kangwon National University) , Seo, Kyoung-Won (College of Veterinary Medicine, Chungnam National University) , Song, Kun-Ho (College of Veterinary Medicine, Chungnam National University)

Abstract ▼ AI-Helper

The aim of the present study is to investigate the potential influence of obesity as a factor in 5-hydroxytryptamine (5-HT) concentration in myxomatous mitral valve disease (MMVD) dogs. Fifty-five client-owned dogs were enrolled in a randomized trial. Dogs were classified by echocardiography into healthy (control), mild, and moderate to severe MMVD groups. Each group was subclassified by using a 9-point body condition score (BCS); lean (BCS 5-6/9) and obese groups (BCS 7.5-9/9). Dogs with moderate to severe MMVD had lower serotonin (5-HT) concentrations than the control group (p = 0.03). Dogs with moderate to severe MMVD (p = 0.017) had lower serum 5-HT concentrations than the control group in the obese group (BCS 7.5-9/9). Significant difference was found between the lean and obese groups (p = 0.015) which are not consider severe in the MMVD group. These results suggested that 5-HT concentration was decreased with the increasing severity of MMVD, and obesity might be taken into consideration when interpreting the serotonin concentration in MMVD dogs.

주제어

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문제 정의

Another study demonstrated no significant difference in the 5-HT concentration of dogs with MMVD compared to healthy dogs [9]. Therefore, the aim of the present study is to investigate the potential influence of obesity to 5-HT concentration in MMVD dogs.

제안 방법

Echocardiography was performed to verify the diagnosis of MMVD and to assess the severity of MMVD. The left atrial to aortic root ratio was measured from the right 2-dimentional short-axis view.

대상 데이터

Three populations of client-owned dogs were prospectively recruited at the Veterinary Medical Teaching Hospitals of Chungnam National University, Konkuk University and Kangwon National University between May 2013 and July 2014. Fifty-five dogs (22 males and 33 females) were enrolled in the current study. The control group consisted of 15 dogs with 2 mixed breeds, 1 Bedlington terrier, 1 Borzoi, 1 Boxer, 4 Yorkshire terriers, and 6 Beagles.
The control group consisted of 15 dogs with 2 mixed breeds, 1 Bedlington terrier, 1 Borzoi, 1 Boxer, 4 Yorkshire terriers, and 6 Beagles. The MMVD groups consisted of 41 dogs with evidence of MMVD on echocardiography and 20 dogs that had mild MMVD and, 21 dogs that had severe MMVD. Each group classified by a body condition score (BCS) (Table 1) consisted of the control group (7 lean, 7 obese), the mild group (12 lean, 8 obese), and the moderate to severe group (14 lean, 7 obese).
Fifty-five dogs (22 males and 33 females) were enrolled in the current study. The control group consisted of 15 dogs with 2 mixed breeds, 1 Bedlington terrier, 1 Borzoi, 1 Boxer, 4 Yorkshire terriers, and 6 Beagles. The MMVD groups consisted of 41 dogs with evidence of MMVD on echocardiography and 20 dogs that had mild MMVD and, 21 dogs that had severe MMVD.

데이터처리

If a significant association (p < 0.05) was detected, a pair-wise comparison was performed by use of the Duncan-test.
05 was considered significant. The one-way ANOVA was used to investigate overall associations between 5-HT concentration and the control and 2 MMVD groups. If a significant association (p < 0.

성능/효과

In conclusion, 5-HT concentration was decreased with the increasing in severity of MMVD. The result is similar to that of Ljungvall [8].
In the obese group (BCS 7.5–9), significantly lower 5-HT concentrations were observed between the control and the moderate to severe MMVD groups (Fig. 2D), although no significant difference was observed between the control group and the mild MMVD group.

후속연구

Samples obtained from the obese dogs in moderate to severe MMVD group were of a small sample size. Further study should be performed using larger samples and in relation to the potential influence of obesity in the 5-HT concentration of MMVD dogs.

참고문헌 (14)

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