Objectives: This study compared the impact of implant surface treatment on the stability and osseointegration of implants in dog mandibles. Materials and Methods: Six adult dogs received a total of 48 implants that were prepared using four different surface treatments; resorbable blast media (RBM), ...
Objectives: This study compared the impact of implant surface treatment on the stability and osseointegration of implants in dog mandibles. Materials and Methods: Six adult dogs received a total of 48 implants that were prepared using four different surface treatments; resorbable blast media (RBM), hydroxyapatite (HA), hydrothermal-treated HA, and sand blasting and acid etching (SLA). Implants were installed, and dogs were separated into 2- and 4-week groups. Implant stability was evaluated via Periotest M, Osstell Mentor, and removal torque analyzers. A histomorphometric analysis was also performed. Results: The stability evaluation showed that all groups generally had satisfactory values. The histomorphometric evaluation via a light microscope revealed that the HA surface implant group had the highest ratio of new bone formation on the entire fixture. The hydrothermal-treated HA surface implant group showed a high ratio of bone-to-implant contact in the upper half of the implant area. Conclusion: The hydrothermal-treated HA implant improved the bone-to-implant contact ratio on the upper fixture, which increased the implant stability.
Objectives: This study compared the impact of implant surface treatment on the stability and osseointegration of implants in dog mandibles. Materials and Methods: Six adult dogs received a total of 48 implants that were prepared using four different surface treatments; resorbable blast media (RBM), hydroxyapatite (HA), hydrothermal-treated HA, and sand blasting and acid etching (SLA). Implants were installed, and dogs were separated into 2- and 4-week groups. Implant stability was evaluated via Periotest M, Osstell Mentor, and removal torque analyzers. A histomorphometric analysis was also performed. Results: The stability evaluation showed that all groups generally had satisfactory values. The histomorphometric evaluation via a light microscope revealed that the HA surface implant group had the highest ratio of new bone formation on the entire fixture. The hydrothermal-treated HA surface implant group showed a high ratio of bone-to-implant contact in the upper half of the implant area. Conclusion: The hydrothermal-treated HA implant improved the bone-to-implant contact ratio on the upper fixture, which increased the implant stability.
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제안 방법
A total of 48 implants had identical lengths and diameters (3.7×8.0 mm) and were classified into 2- and 4-week groups.
In this study, we determined the degree of osseointegration using the Periotest M and Osstell Mentor to estimate implant stability, and we used the MGT 50 gauge to estimate the removal torque. The PTV can be used clinically to estimate the histological degree of osseointegration, and the movement of the metal rod is a convenient and useful way to estimate implant stability 17 .
In this study, we examined implant osseointegration using four types of implant surface treatment; RBM, HA coating, HA coating combined with hot water treatment, and SLAtreated implants in the jawbone of adult dogs. In general, all types of implant treatments led to good implant stability.
Osstell Mentor (Integration Diagnostics AB, Göteberg, Sweden) was used to simultaneously estimate the implant stability quotient (ISQ) via resonance frequency analysis (RFA) on the medial, distal, buccal and lingual sides of the implant.
Two months after extracting the teeth, the right mandible of each animal was treated with local anesthetic followed by anesthesia induction. The four types of implants were inserted according to the surface treatment; implants treated with RBM (Clearant; Dentis Inc., Daegu, Korea), HA implants coated with ultra-thin HA film at room temperature (Haptite; Dentis Inc.), hydrothermal-treated HA implants treated with hot water and coated with HA (Dentis Inc.), and SLA implants treated with plasma spray followed by acid etching (One Q SL; Dentis Inc.). A total of 48 implants had identical lengths and diameters (3.
The specimens were cut using a high-precision diamond disc and polished to 50 μm or less in thickness, using a lapping and polishing machine (OMNILAP 2000; SBT, San Clemente, CA, USA).
This study involved implants that were treated with recently commercialized RBM, as well as HA or SLA. RBM is used to spray resorbable blast material, such as hydrated titanium and calcium phosphate, to make the surface of the implant coarse 18 ; Piattelli et al.
To test the primary fixation and stability of the implants, Periotest M (Medizintechnik Gulden Co., Modautal, Germany) was used to estimate the periotest value (PTV) as a representative value on the buccal side of each implant directly after placement and sacrifice. Osstell Mentor (Integration Diagnostics AB, Göteberg, Sweden) was used to simultaneously estimate the implant stability quotient (ISQ) via resonance frequency analysis (RFA) on the medial, distal, buccal and lingual sides of the implant.
대상 데이터
The experiments were carried out using six healthy adult dogs aged 18 to 24 months and the study was approved by the Institutional Animal Care and Use Committee, Chosun University (IRB No. CIACUC2013-A0019). Each dog was injected intramuscularly in the thigh with muscle relaxant (2% xylazine hydrochloride, 10 mg/kg, Rompun Inj.
0 mm) and were classified into 2- and 4-week groups. Two implants from each group (a total of eight implants) were inserted in each dog. Furthermore, each implant was inserted up to 1 mm in depth on the superior border of the alveolar bone, with more than 35-N insertion torque.
데이터처리
, Armonk, NY, USA) was used to analyze each of the estimates. Statistical significance was determined by one-way ANOVA, and statistical analysis was carried out at the 95% confidence level.
성능/효과
Ishizawa and Ogino28 reported that anodized titanium coating, combined with 300o C water treatment, yielded a 1- to 2-μm layer of HA, which could decrease particle cohesion and increase the maximum bond stress up to 40 MPa. In this study, hot water treatment, in conjunction with new technology to improve crystallinity of the particles, also led to better BIC than the HA, RBM and SLA coatings on average, although the differences were not statistically significant.
An optical microscope (Olympus BX50; Olympus, Tokyo, Japan) was used for the histomorphometric assessment. The ratio of the new bone formation area (NBFA) to the entire implant was determined, and the bone-implant contact (BIC) on the upper half was examined, which was determined to be more significant for implant stability. PASW Statistics version 18 (IBM Co.
20 found no statistical significance in the histomorphometric analysis in adult dogs that received acid-etched and RBM-treated implants. This study found that RBM-treated implants resulted in poor osseointegration with relatively smaller BIC or removal torque on average than HA-coated implants, although this trend was not statistically significant.
후속연구
Hydrothermal-treated HA showed excellent osseointegration in the upper half of the implant. To improve osseointegration, further research is required to combine the existing implant surface treatment methods with modified and improved technology.
참고문헌 (31)
1 Mueller CK Thorwarth M Schmidt M Schlegel KA Schultze-Mosgau S Comparative analysis of osseointegration of titanium implants with acid-etched surfaces and different biomolecular coatings Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 112 726 736 21441047
2 Abuhussein H Pagni G Rebaudi A Wang HL The effect of thread pattern upon implant osseointegration Clin Oral Implants Res 2010 21 129 136 19709058
3 de Vicente JC Recio O Martín-Villa L Junquera LM López-Arranz JS Histomorphometric evaluation of guided bone regeneration around implants with SLA surface: an experimental study in beagle dogs Int J Oral Maxillofac Surg 2006 35 1047 1053 16973332
4 Albrektsson T Brånemark PI Hansson HA Lindström J Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man Acta Orthop Scand 1981 52 155 170 7246093
5 Brånemark PI Adell R Breine U Hansson BO Lindström J Ohlsson A Intra-osseous anchorage of dental prostheses. I. Experimental studies Scand J Plast Reconstr Surg 1969 3 81 100 4924041
6 Shalabi MM Gortemaker A Van't Hof MA Jansen JA Creugers NH Implant surface roughness and bone healing: a systematic review J Dent Res 2006 85 496 500 16723643
8 Buser D Schenk RK Steinemann S Fiorellini JP Fox CH Stich H Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs J Biomed Mater Res 1991 25 889 902 1918105
9 Le Guéhennec L Soueidan A Layrolle P Amouriq Y Surface treatments of titanium dental implants for rapid osseointegration Dent Mater 2007 23 844 854 16904738
10 Buser D Broggini N Wieland M Schenk RK Denzer AJ Cochran DL Enhanced bone apposition to a chemically modified SLA titanium surface J Dent Res 2004 83 529 533 15218041
11 Ellingsen JE Johansson CB Wennerberg A Holmén A Improved retention and bone-tolmplant contact with fluoride-modified titanium implants Int J Oral Maxillofac Implants 2004 19 659 666 15508981
12 Jeong R Marin C Granato R Suzuki M Gil JN Granjeiro JM Early bone healing around implant surfaces treated with variations in the resorbable blasting media method. A study in rabbits Med Oral Patol Oral Cir Bucal 2010 15 e119 e125 19767688
13 Meredith N Book K Friberg B Jemt T Sennerby L Resonance frequency measurements of implant stability in vivo. A cross-sectional and longitudinal study of resonance frequency measurements on implants in the edentulous and partially dentate maxilla Clin Oral Implants Res 1997 8 226 233 9586467
14 Ratner BD Porter SC Surfaces in biology and biomaterials: description and characterization Brash JL Wojciechowski PW Interfacial phenomena and bioproducts New York Marcel Dekker 1996 57 83
16 Schwarz ML Kowarsch M Rose S Becker K Lenz T Jani L Effect of surface roughness, porosity, and a resorbable calcium phosphate coating on osseointegration of titanium in a minipig model J Biomed Mater Res A 2009 89 667 678 18442101
17 Olivé J Aparicio C Periotest method as a measure of osseointegrated oral implant stability Int J Oral Maxillofac Implants 1990 5 390 400 2094658
18 Coelho PG Granjeiro JM Romanos GE Suzuki M Silva NR Cardaropoli G Basic research methods and current trends of dental implant surfaces J Biomed Mater Res B Appl Biomater 2009 88 579 596 18973274
19 Piattelli M Scarano A Paolantonio M Iezzi G Petrone G Piattelli A Bone response to machined and resorbable blast material titanium implants: an experimental study in rabbits J Oral Implantol 2002 28 2 8 12498456
20 Granato R Marin C Suzuki M Gil JN Janal MN Coelho PG Biomechanical and histomorphometric evaluation of a thin ion beam bioceramic deposition on plateau root form implants: an experimental study in dogs J Biomed Mater Res B Appl Biomater 2009 90 396 403 19107801
21 Yang GL He FM Yang XF Wang XX Zhao SF Bone responses to titanium implants surface-roughened by sandblasted and double etched treatments in a rabbit model Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 106 516 524 18602288
22 Cochran DL Schenk RK Lussi A Higginbottom FL Buser D Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible J Biomed Mater Res 1998 40 1 11 9511093
23 Block MS Kent JN Kay JF Evaluation of hydroxylapatite-coated titanium dental implants in dogs J Oral Maxillofac Surg 1987 45 601 607 3037051
24 Jones JD Lupori J Van Sickels JE Gardner W A 5-year comparison of hydroxyapatite-coated titanium plasma-sprayed and titanium plasma-sprayed cylinder dental implants Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999 87 649 652 10397651
25 Cook SD Baffes GC Palafox AJ Wolfe MW Burgess A Torsional stability of HA-coated and grit-blasted titanium dental implants J Oral Implantol 1992 18 354 365 1298818
26 Radin SR Ducheyne P Plasma spraying induced changes of calcium phosphate ceramic characteristics and the effect on in vitro stability J Mater Sci Mater Med 1992 3 33 42
27 Yang GL He FM Hu JA Wang XX Zhao SF Effects of biomimetically and electrochemically deposited nano-hydroxyapatite coatings on osseointegration of porous titanium implants Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009 107 782 789 19201624
28 Ishizawa H Ogino M Characterization of thin hydroxyapatite layers formed on anodic titanium oxide films containing Ca and P by hydrothermal treatment J Biomed Mater Res 1995 29 1071 1079 8567705
29 Braceras I Alava JI Goikoetxea L de Maeztu MA Onate JI Interaction of engineered surfaces with the living world: ion implantation vs. osseointegration Surf Coat Technol 2007 201 8091 8098
30 Yang B Uchida M Kim HM Zhang X Kokubo T Preparation of bioactive titanium metal via anodic oxidation treatment Biomaterials 2004 25 1003 1010 14615165
31 De Maeztu MA Braceras I Alava JI Gay-Escoda C Improvement of osseointegration of titanium dental implant surfaces modified with CO ions: a comparative histomorphometric study in beagle dogs Int J Oral Maxillofac Surg 2008 37 441 447 18339518
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