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Effects of Oil type on the Stability of Oil-in-Water Lipid Nanoemulsion 원문보기

한국유화학회지 = Journal of oil & applied science, v.33 no.4, 2016년, pp.667 - 675  

Lee, Seung-Jun (Department of Chemical & Biomolecular Eng., KAIST) ,  Han, Sa Ra (Department of Chemical Engineering, Soongsil University) ,  Jeong, Jae Hyun (Department of Chemical Engineering, Soongsil University) ,  Kim, Jong-Duk (Department of Chemical & Biomolecular Eng., KAIST)

Abstract AI-Helper 아이콘AI-Helper

Nanoemulsions are actively used in several applications for pharmaceutical, cosmetic and chemical industries. In this study, we propose the use of microfluidizer known as high pressure homogenizer to prepare lipid nanoemulsion as a potent cosmetic delivery carrier. The lipid nanoemulsions were prepa...

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제안 방법

  • Precisely controlled emulsification forces generated by this technique include high shear (laminar flow), turbulence (inertial flow), and cavitation (vapor bubble implosion) with these mechanical forces acting together to reduce mean droplet diameter of the dispersed phase [16-17]. The purpose of this study was to formulate lipid nanoemulsions and study the influence of the processing technique such as homogenization and microfluidization on the initial droplet diameter and rate of droplet aggregation in an oil-in-water emulsion system with respect to various oil types. Also, we investigated the effect of various oil types on the skin permeability.

대상 데이터

  • We investigated the effect of various oils on the skin permeability and the effect of microfluidizer and homogenizer. Eleven oil types consist of D-7, TIO, CIO, MCT, SQ, 6CS, 556, Octyldo, ODM, ICEM and ICMR. Percutaneous absorption was monitored for total period of 2 – 24 h (Fig.

이론/모형

  • water. The particle size of nanoemulsion was measured by dynamic light scattering method based on the particle size option in ZetaPlus. The scattered intensity was registered at the scattering angle of 90° and temperature of 298.
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참고문헌 (17)

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  2. O. Bengu, A. Sanem, O. Mustafa, and J. M. David, Formation and stabilization of nanoemulsion-based vitamin E delivery systems using natural surfactants: Quillaja saponin and lecithin, J. Food Eng., 142, 57(2014). 

  3. S. B. Daniela, A. P. Tatiana, R. M. Naira, B. Josiane, S. V. Gisely, C. O. Gustavo, and A. R. Pedro, Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments, J. Nanobiotechnology, 9, 44(2011). 

  4. B. J. An, J. T. Lee, I. C. Lee, and J. H. Kwak, Preparation and stabilization of an O/W emulsion using liquid crystalline phases, J. Korean Chem. Soc., 21(1), 31(2004). 

  5. B. G. Park, S. W. Lee, H. G. Chat, S. Y. Eom, J. H. Kim, and H. G. Ji, Study on nanoemulsion using various lecithins and oils, 9(1), 379(2003). 

  6. Y. Reiko, S. Y. Morita, T. Reiko., and K. Shuji, Distribution of polyphenols and a surfactant component in skin during aerosol OT microemulsion-enhanced intradermal delivery, Chem. Pharm. Bull., 60(8), 989(2012). 

  7. Y. Reiko, T. Reiko, and K. Shuji, Microemulsion using polyoxyethylene sorbitan trioleate and its usage for skin delivery of resveratrol to protect skin against UV-induced damage, Chem. Pharm. Bull., 63(9), 741(2015). 

  8. H. Sonja, S. Andrea, and V. Claudia, Lecithin based nanoemulsion: A comparative study of the influence of non-ionic surfactatns and the cationic phytosphingosine on physicochemical behvour and skin permeation, Int. J. Pharm., 370(1), 181(2009). 

  9. S. P. Jiang, S. N. He, Y. L. Li, D. L. Feng, X. Y. Lu, Y. Z. Du, H. Y. Yu, F. Q. Hu, and H. Yuan, Preparation and characteristics of lipid nanoemulsion formulations loaded with doxorubicin, Int. J. Nanomedicine, 8, 3141(2013). 

  10. H. Zhou, Y. Yue, G. Liu, Y. Li, J. Zhang, and Q. Gong, Preparation and characterization of a lecithin nanoemulsion as a topical delivery system, Nanoscale Res. Lett., 5, 224(2009). 

  11. J. W. Jung, C. Y. Yoo, and S. N. Park, Preparation of lipquid crystalPreparation of Liquid Crystal Emulsion for Transdermal Delivery of Glycyrrhizic Acid and Physical Characteristics and In Vitro Skin Permeation Studies, J. Korean Chem. Soc., 41(4), 315(2015). 

  12. Y. Nakada, E. Fattal, M. Foulquier, and P. Couvreur, Pharmacokinetics and biodistribution of oligonucleotide adsorbed onto poly(isobutylcyanoacrylate) nanoparticles after intravenous administration in mice, J. Pharm. Res., 13, 38(1996). 

  13. Y. Yuan, Y. Gao, J. Zhao, and L. Mao, Characterization and stability evaluation of ${\beta}$ -carotene nanoemulsions prepared by high pressure homogenization under various emulsifying conditions, Food Res. Int., 41(1), 61(2008). 

  14. A. Lamprecht, N. Ubrich, M. Hombreiro Perez, C. M. Lehr, M. Hoffman, and P. Maincent, Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure jomogenization technique, Int. J. Pharm., 196(2), 177(2000). 

  15. W. G. Cho and E. H. Kim, Effect of polymers to nano-emulsion stability, J. Korean Chem. Soc., 30(2), 339(2013). 

  16. S. Pinnamaneni1, N. G. Das, and S. K. Das, Comparison of oil-in-water emulsions manufactured by microfluidization and homogenization, Pharmazie, 58(8), 554(2003). 

  17. H. Korstvedt, R. Bates, J. King, and A. Siciliano, Microfluidization, Drugs Cosmet. Ind., 11, 36(1984). 

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