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NTIS 바로가기한국식품위생안전성학회지 = Journal of food hygiene and safety, v.31 no.2, 2016년, pp.67 - 73
최승국 (고려대학교 생명과학대학 생명공학부 대사공학연구실) , 문현석 (고려대학교 생명과학대학 생명공학부 대사공학연구실)
Resveratrol is a non-flavonoid polyphenol which belongs to the stilbenes group and is naturally generated in several plants in response to damage or fungal invasion. It has been shown in published studies that resveratrol has an anti-adipogenic effect. A good consensus regarding the involvement of a...
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핵심어 | 질문 | 논문에서 추출한 답변 |
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레스베라트롤이란 무엇인가? | 레스베라트롤(trans-3,4',5-trihydroxystilbene) (Fig. 1)은 스틸벤(stilbene)과에 속해있으며 몇몇 식물에서 상처나 균에 반응하여 자연적으로 생겨나는 비-플라보노이드 폴리페놀이다1). 레스베라트롤은 흰색 백합의 뿌리에서 발견되었고 포도, 베리, 레드 와인 및 견과류 같은 다양한 식품에 함유되어 있다2). | |
장과 간에서 레스베라트롤 대사에 관여하는 효소는 무엇인가? | 분자의 형태는 trans-레스베라트롤과 cis-레스베라트롤의 두 개의 이형체로 존재하는데, 이 2가지 중 trans의 형태가 상대적으로 안정하다3). 특히, 레스베라트롤은 phase II 효소에 의해 장과 간에서 빠르게 대사된다4). 이 대사작용의 최종 산물은 주로 glucuronide와 sulfate derivatives이고, 이 물질들은 결장의 미생물에 의해 대사산물인 dihydroresveratrol로 생성되어 진다5). | |
레스베라트롤 대사작용의 최종 산물은 무엇인가? | 특히, 레스베라트롤은 phase II 효소에 의해 장과 간에서 빠르게 대사된다4). 이 대사작용의 최종 산물은 주로 glucuronide와 sulfate derivatives이고, 이 물질들은 결장의 미생물에 의해 대사산물인 dihydroresveratrol로 생성되어 진다5). 레스베라트롤은 심혈관 질환 및 암과 같은 다양한 질병을 예방하거나 감소시킬 수 있고 염증과 산화 스트레스를 감소시키고, 수명을 연장 시킨다6,7). |
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