$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Quercetin and quercetin-3-β-ᴅ-glucoside improve cognitive and memory function in Alzheimer's disease mouse 원문보기

Applied Biological Chemistry = 한국응용생명화학회지, v.59 no.5, 2016년, pp.721 - 728  

Kim, Ji Hyun (Department of Food Science and Nutrition and Kimchi Research Institute, Pusan National University) ,  Lee, Jaemin (Department of Integrative Plant Science, Chung-Ang University) ,  Lee, Sanghyun (Department of Integrative Plant Science, Chung-Ang University) ,  Cho, Eun Ju (Department of Food Science and Nutrition and Kimchi Research Institute, Pusan National University)

Abstract AI-Helper 아이콘AI-Helper

We investigated the protective activities of quercetin (Q) and quercetin-3-${\beta}$-${\small{D}}$-glucoside (Q3G) under $A{\beta}_{25-35}$-injected Alzheimer's disease (AD) model mice. To induce an AD-like disease in an in vivo model, mice were injected with $A...

주제어

참고문헌 (59)

  1. J Nutr Biochem MA Ansari 20 269 2009 10.1016/j.jnutbio.2008.03.002 Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA (2009) Protective effect of quercetin in primary neurons against Aβ (1-42): relevance to Alzheimer’s disease. J Nutr Biochem 20:269-275 

  2. J Neurochem NA Avdulov 68 2086 1997 10.1046/j.1471-4159.1997.68052086.x Avdulov NA, Chochina SV, Igbavboa U, O’Hare EO, Schroeder F, Cleary JP, Wood WG (1997) Amyloid beta-peptides increase annular and bulk fluidity and induce lipid peroxidation in brain synaptic plasma membranes. J Neurochem 68:2086-2091 

  3. Nat Protoc RA Bevins 1 1306 2006 10.1038/nprot.2006.205 Bevins RA, Besheer J (2006) Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study ‘recognition memory’. Nat Protoc 1:1306-1311 

  4. Annu Rev Biochem DS Bredt 63 175 1994 10.1146/annurev.bi.63.070194.001135 Bredt DS, Snyder SH (1994) Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 63:175-195 

  5. Free Radic Biol Med DA Butterfield 32 1050 2002 10.1016/S0891-5849(02)00794-3 Butterfield DA, Lauderback CM (2002) Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med 32:1050-1060 

  6. Nutr Res YY Choi 34 595 2014 10.1016/j.nutres.2014.06.008 Choi YY, Maeda T, Fujii H, Yokozawa T, Kim HY, Cho EJ, Shibamoto T (2014) Oligonol improves memory and cognition under an amyloid β 25-35-induced Alzheimer’s mouse model. Nutr Res 34:595-603 

  7. J Med Food JY Choi 18 631 2015 10.1089/jmf.2014.3292 Choi JY, Lee JM, Lee DG, Cho S, Yoon YH, Cho EJ, Lee S (2015) The n-butanol fraction and rutin from tartary buckwheat improve cognition and memory in an in vivo model of amyloid-β-induced Alzheimer’s disease. J Med Food 18:631-641 

  8. Braz J Med Biol Res F Dajas 36 1613 2003 10.1590/S0100-879X2003001200002 Dajas F, Rivera-Megret F, Blasina F, Arredondo F, Abin-Carriquiry JA, Costa G, Echeverry C, Lafon L, Heizen H, Ferreira M, Morquio A (2003) Neuroprotection by flavonoids. Braz J Med Biol Res 36:1613-1620 

  9. Neurochem Int F Dajas 89 140 2015 10.1016/j.neuint.2015.07.002 Dajas F, Abin-Carriquiry JA, Arredondo F, Blasina F, Echeverry C, Martínez M, Rivera F, Vaamonde L (2015) Quercetin in brain diseases: potential and limits. Neurochem Int 89:140-148 

  10. J Nutr S Egert 138 1615 2008 10.1093/jn/138.9.1615 Egert S, Wolffram S, Bosy-Westphal A, Boesch-Saadatmandi C, Wagner AE, Frank J, Rimbach G, Mueller MJ (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138:1615-1621 

  11. Neurobiol Aging SA Frautschy 22 993 2001 10.1016/S0197-4580(01)00300-1 Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GM (2001) Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging 22:993-1005 

  12. J vis exp JJ Glascock 56 2968 2011 Glascock JJ, Osman EY, Coady TH, Rose FF, Shababi M, Lorson CL (2011) Delivery of therapeutic agents through intracerebroventricular (ICV) and intravenous (IV) injection in mice. J Vis Exp 56:2968 

  13. Nat Rev Mol Cell Biol C Haass 8 101 2007 10.1038/nrm2101 Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid beta-peptide. Nat Rev Mol Cell Biol 8:101-112 

  14. J Nutr Biochem AM Haque 19 619 2008 10.1016/j.jnutbio.2007.08.008 Haque AM, Hashimoto M, Katakura M, Hara Y, Shido O (2008) Green tea catechins prevent cognitive deficits caused by Aβ1-40 in rats. J Nutr Biochem 19:619-626 

  15. J Agric Food Chem HJ Heo 52 7514 2004 10.1021/jf049243r Heo HJ, Lee CY (2004) Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration. J Agric Food Chem 52:7514-7517 

  16. Neurochem Int CI Janssen 89 157 2015 10.1016/j.neuint.2015.05.002 Janssen CI, Zerbi V, Mutsaers MP, Jochems M, Vos CA, Vos JO, Berg BM, van Tol EA, Gross G, Jouni ZE, Heerschap A, Kiliaan AJ (2015) Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6 J mice. Neurochem Int 89:157-169 

  17. J Alzheimers Dis C Ji 14 271 2008 10.3233/JAD-2008-14302 Ji C, Aisa HA, Yang N, Li Q, Wang T, Zhang L, Qu K, Zhu HB, Zuo PP (2008) Gossypium herbaceam extracts inhibited NF-kappaB activation to attenuate spatial memory impairment and hippocampal neurodegeneration induced by amyloid-beta in rats. J Alzheimers Dis 14:271-283 

  18. Life Sci K Jiménez-Aliaga 89 939 2011 10.1016/j.lfs.2011.09.023 Jiménez-Aliaga K, Bermejo-Bescós P, Benedí J, Martín-Aragón S (2011) Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells. Life Sci 89:939-945 

  19. J Neurochem JN Keller 69 273 1997 10.1046/j.1471-4159.1997.69010273.x Keller JN, Pang Z, Geddes JW, BeBegley JG, Germeyer A, Waeg G, Mattson MP (1997) Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal. J Neurochem 69:273-284 

  20. Free Radic Biol Med TI Kim 47 1601 2009 10.1016/j.freeradbiomed.2009.09.008 Kim TI, Lee YK, Park SG, Choi IS, Ban JO, Park HK, Nam SY, Yun YW, Han SB, Oh KW, Hong JT (2009) l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways. Free Radic Biol Med 47:1601-1610 

  21. J Neurochem J Kim 112 1415 2010 10.1111/j.1471-4159.2009.06562.x Kim J, Lee HJ, Lee KW (2010) Naturally occurring phytochemicals for the prevention of Alzheimer’s disease. J Neurochem 112:1415-1430 

  22. J Pharmacol Methods SE Laursen 16 355 1986 10.1016/0160-5402(86)90038-0 Laursen SE, Belknap JK (1986) Intracerebroventricular injections in mice some methodological refinements. J Pharmacol Methods 16:355-357 

  23. Am J Epidemiol L Letenneur 165 1364 2007 10.1093/aje/kwm036 Letenneur L, Proust-Lima C, Le Gouge A, Dartigues JF, Barberger-Gateau P (2007) Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol 165:1364-1371 

  24. Neuropharmacology R Liu 67 419 2013 10.1016/j.neuropharm.2012.11.018 Liu R, Zhang TT, Zhou D, Bai XY, Zhou WL, Huang C, Song JK, Meng FR, Wu CX, Li L, Du GH (2013) Quercetin protects against the Aβ25-35-induced amnesic injury: involvement of inactivation of rage-mediated pathway and conservation of the NVU. Neuropharmacology 67:419-431 

  25. Proc Natl Acad Sci USA DT Loo 90 7951 1993 10.1073/pnas.90.17.7951 Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW (1993) Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 90:7951-7955 

  26. Am J Clin Nutr C Manach 81 230S 2005 10.1093/ajcn/81.1.230S Manach C, Williamson G, Morand C, Scalbert A, Rémésy C (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81:230S-242S 

  27. Neurobiol Aging WR Markesbery 19 33 1998 10.1016/S0197-4580(98)00009-8 Markesbery WR, Lovell MA (1998) Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer’s disease. Neurobiol Aging 19:33-36 

  28. Nature MP Mattson 430 631 2004 10.1038/nature02621 Mattson MP (2004) Pathways towards and away from Alzheimer’s disease. Nature 430:631-639 

  29. Brain Res T Maurice 706 181 1996 10.1016/0006-8993(95)01032-7 Maurice T, Lockhart BP, Privat A (1996) Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction. Brain Res 706:181-193 

  30. J Comp Physiol Psychol KC Montgomery 45 287 1952 10.1037/h0058118 Montgomery KC (1952a) A test of two explanations of spontaneous alternation. J Comp Physiol Psychol 45:287-293 

  31. J Comp Physiol Psychol KC Montgomery 45 50 1952 10.1037/h0053570 Montgomery KC (1952b) Exploratory behavior and its relation to spontaneous alternation in a series of maze exposures. J Comp Physiol Psychol 45:50-57 

  32. J Neurosci Methods R Morris 11 47 1984 10.1016/0165-0270(84)90007-4 Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47-60 

  33. Anal Biochem H Ohkawa 95 351 1979 10.1016/0003-2697(79)90738-3 Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358 

  34. J Neurochem K Ono 87 172 2003 10.1046/j.1471-4159.2003.01976.x Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M (2003) Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer’s disease. J Neurochem 87:172-181 

  35. Ann Neurol JL Price 45 358 1999 10.1002/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and preclinical Alzheimer’s disease. Ann Neurol 45:358-368 

  36. Trends Mol Med PH Reddy 14 45 2008 10.1016/j.molmed.2007.12.002 Reddy PH, Beal MF (2008) Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer’s disease. Trends Mol Med 14:45-53 

  37. Genes Nutr C Rendeiro 4 251 2009 10.1007/s12263-009-0137-2 Rendeiro C, Spencer JP, Vauzour D, Butler LT, Ellis JA, Williams CM (2009) The impact of flavonoids on spatial memory in rodents: from behavior to underlying hippocampal mechanisms. Genes Nutr 4:251-270 

  38. Neurochem Int C Rendeiro 89 126 2015 10.1016/j.neuint.2015.08.002 Rendeiro C, Rhodes JS, Spencer JP (2015) The mechanisms of action of flavonoids in the brain: direct versus indirect effects. Neurochem Int 89:126-139 

  39. Neuropharmacology AM Sabogal-Guáqueta 93 134 2015 10.1016/j.neuropharm.2015.01.027 Sabogal-Guáqueta AM, Muñoz-Manco JI, Ramírez-Pineda JR, Lamprea-Rodriguez M, Osorio E, Cardona-Gómez GP (2015) The flavonoid quercetin ameliorates Alzheimer’s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer’s disease model mice. Neuropharmacology 93:134-145 

  40. Mol Pharmacol HH Schmidt 41 615 1992 Schmidt HH, Warner TD, Nakane M, Förstermann U, Murad F (1992) Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages. Mol Pharmacol 41:615-624 

  41. Biochim Biophys Acta Y Shimmyo 1780 819 2008 10.1016/j.bbagen.2008.01.017 Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H (2008) Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochim Biophys Acta 1780:819-825 

  42. J Neurosci MA Smith 17 2653 1997 10.1523/JNEUROSCI.17-08-02653.1997 Smith MA, Richey Harris PL, Sayre LM, Beckman JS, Perry G (1997) Widespread peroxynitrite-mediated damage in Alzheimer’s disease. J Neurosci 17:2653-2657 

  43. Neuropsychiatr Dis Treat FA Sorond 4 433 2008 Sorond FA, Lipsitz LA, Hollenberg NK, Fisher ND (2008) Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans. Neuropsychiatr Dis Treat 4:433-440 

  44. J Biol Chem R Soundararajan 283 2231 2008 10.1074/jbc.M703583200 Soundararajan R, Wishart AD, Rupasinghe HP, Arcellana-Panlilio M, Nelson CM, Mayne M, Robertson GS (2008) Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis. J Biol Chem 283:2231-2245 

  45. Genes Nutr JP Spencer 2 257 2007 10.1007/s12263-007-0056-z Spencer JP (2007) The interactions of flavonoids within neuronal signalling pathways. Genes Nutr 2:257-273 

  46. Neurochem Int MY Stepanichev 52 1114 2008 10.1016/j.neuint.2007.11.009 Stepanichev MY, Onufriev MV, Yakovlev AA, Khrenov AI, Peregud DI, Vorontsova ON, Lazareva NA, Gulyaeva NV (2008) Amyloid-β (25-35) increases activity of neuronal NO-synthase in rat brain. Neurochem Int 52:1114-1124 

  47. Neurosci Lett N Suematsu 504 223 2011 10.1016/j.neulet.2011.09.028 Suematsu N, Hosoda M, Fujimori K (2011) Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells. Neurosci Lett 504:223-227 

  48. Ann Neurol RD Terry 30 572 1991 10.1002/ana.410300410 Terry RD, Masliah E, Salmon DP, Butters N, De Teresa R, Hill R, Hansen LA, Katzman R (1991) Physical basis of cognitive alterations in Alzheimer’s disease: synaptic loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580 

  49. FASEB J MH Tran 15 1407 2001 10.1096/fj.00-0719fje Tran MH, Yamada K, Olariu A, Mizuno M, Ren XH, Nabeshima T (2001) Amyloid beta-peptide induces nitric oxide production in rat hippocampus: association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors. FASEB J 15:1407-1409 

  50. Mol Psychiatry MH Tran 8 407 2003 10.1038/sj.mp.4001240 Tran MH, Yamada K, Nakajima A, Mizuno M, He J, Kamei H, Nabeshima T (2003) Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid β-peptide-induced cholinergic dysfunction. Mol Psychiatry 8:407-412 

  51. Neurosci Behav Physiol VV Trubetskaya 33 95 2003 10.1023/A:1021761310435 Trubetskaya VV, Stepanichev MY, Onufriev MV, Lazareva NA, Markevich VA, Gulyaeva NV (2003) Administration of aggregated β-amyloid peptide (25-35) induces changes in long-term potentiation in the hippocampus in vivo. Neurosci Behav Physiol 33:95-98 

  52. J Struct Biol S Varadarajan 130 184 2000 10.1006/jsbi.2000.4274 Varadarajan S, Yatin S, Aksenova M, Butterfield DA (2000) Review: Alzheimer’s amyloid β-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 130:184-208 

  53. Genes Nutr D Vauzour 3 115 2008 10.1007/s12263-008-0091-4 Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr 3:115-126 

  54. Neurochem Res DM Wang 39 1533 2014 10.1007/s11064-014-1343-x Wang DM, Li SQ, Wu WL, Zhu XY, Wang Y, Yuan HY (2014) Effects of long-term treatment with quercetin on cognition and mitochondrial function in a mouse model of Alzheimer’s disease. Neurochem Res 39:1533-1543 

  55. Eur J Pharmacol Y Yamaguchi 412 265 2001 10.1016/S0014-2999(01)00730-0 Yamaguchi Y, Kawashima S (2001) Effects of amyloid-β-(25-35) on passive avoidance, radial-arm maze learning and choline acetyltransferase activity in the rat. Eur J Pharmacol 412:265-272 

  56. Neurobiol Aging SM Yatin 20 325 1999 10.1016/S0197-4580(99)00056-1 Yatin SM, Varadarajan S, Link CD, Butterfield DA (1999) In vitro and in vivo oxidative stress associated with Alzheimer’s amyloid β-peptide (1-42). Neurobiol Aging 20:325-330 

  57. Biol Chem KA Youdim 383 503 2002 10.1515/BC.2002.052 Youdim KA, Spencer JP, Schroeter H, Rice-Evans C (2002) Dietary flavonoids as potential neuroprotectants. Biol Chem 383:503-519 

  58. Free Radic Biol Med KA Youdim 37 1683 2004 10.1016/j.freeradbiomed.2004.08.002 Youdim KA, Shukitt-Hale B, Joseph JA (2004) Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med 37:1683-1693 

  59. J Agric Food Chem JT Zhu 55 2438 2007 10.1021/jf063299z Zhu JT, Choi RC, Chu GK, Cheung AW, Gao QT, Li J, Jiang ZY, Dong TT, Tsim KW (2007) Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death. J Agric Food Chem 55:2438-2445 

LOADING...

관련 콘텐츠

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

이 논문과 함께 이용한 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로